Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Abstract

We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.

© 2008 Optical Society of America

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

Jason R. Maher, Oranat Chuchuen, Marcus H. Henderson, Sanghoon Kim, Matthew T. Rinehart, Angela D. M. Kashuba, Adam Wax, and David F. Katz
Biomed. Opt. Express 6(6) 2022-2035 (2015)

Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization

Yi Yang, Xiang Li, Tianheng Wang, Patrick D. Kumavor, Andres Aguirre, Kirk K. Shung, Qifa Zhou, Melinda Sanders, Molly Brewer, and Quing Zhu
Biomed. Opt. Express 2(9) 2551-2561 (2011)

A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization

Jesung Park, Javier A. Jo, Sebina Shrestha, Paritosh Pande, Qiujie Wan, and Brian E. Applegate
Biomed. Opt. Express 1(1) 186-200 (2010)

Characterizing of tissue microstructure with single-detector polarization-sensitive optical coherence tomography

Bin Liu, Michelle Harman, Susanne Giattina, Debra L Stamper, Charles Demakis, Mark Chilek, Stephanie Raby, and Mark E. Brezinski
Appl. Opt. 45(18) 4464-4479 (2006)

Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements

Jianfeng Wang, Wei Zheng, Kan Lin, and Zhiwei Huang
Opt. Lett. 41(13) 3045-3048 (2016)