Abstract

We show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium using ultrasound-modulated optical tomography (UOT). While the spatial resolution depends on ultrasound parameters, the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements obtained with a CCD-based speckle contrast detection scheme are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast.

© 2007 Optical Society of America

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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]

2006 (7)

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

R. Zemp, S. Sakadzic, and L.-H. V. Wang, Phys. Rev. E 73, 061920 (2006).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 74, 036618 (2006).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. Lett. 96, 163902 (2006).
[CrossRef] [PubMed]

C. Kim, R. J. Zemp, and L-H. V. Wang, Opt. Lett. 31, 2423 (2006).
[CrossRef] [PubMed]

A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas, Opt. Lett. 31, 3459 (2006).
[CrossRef] [PubMed]

2005 (2)

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 72, 036620 (2005).
[CrossRef]

H. Inoue, S. Kudo, and A. Shiokawa, Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 31 (2005).
[CrossRef] [PubMed]

2004 (4)

2003 (3)

A. Lev and B. G. Sfez, Opt. Lett. 28, 1549 (2003).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

J. G. Fujimoto, Nat. Biotechnol. 21, 1361 (2003).
[CrossRef] [PubMed]

2002 (1)

2001 (2)

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

L.-H. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[CrossRef] [PubMed]

1999 (1)

1997 (1)

Aguirre, A. D.

Birgul, O.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

Blonigen, F.

Boas, D. A.

A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas, Opt. Lett. 31, 3459 (2006).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Boccara, A. C.

Brooks, D. H.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Chen, Y.

Dehghani, H.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Devor, A.

DiMarzio, C. A.

T. W. Murray, L. Sui, G. Maguluri, R. A. Roy, A. Nieva, F. Blonigen, and C. A. DiMarzio, Opt. Lett. 29, 2509 (2004).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Fujimoto, J. G.

Gaudette, R. J.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Gibson, J. J.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Gu, X.

H. Zhao, X. Gu, and H. Jiang, Opt. Commun. 238, 51 (2004).
[CrossRef]

Gulsen, G.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

Inoue, H.

H. Inoue, S. Kudo, and A. Shiokawa, Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 31 (2005).
[CrossRef] [PubMed]

Jiang, H.

H. Zhao, X. Gu, and H. Jiang, Opt. Commun. 238, 51 (2004).
[CrossRef]

Jiang, S.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Kilmer, M.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Kim, C.

Kogel, C.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Ku, G.

Kudo, S.

H. Inoue, S. Kudo, and A. Shiokawa, Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 31 (2005).
[CrossRef] [PubMed]

Lebec, M.

Lev, A.

Leveque, S.

Li, J.

Maguluri, G.

Marquez, G.

Maslov, K.

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Miller, E. L.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Murray, T. W.

Nalcioglu, O.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

Nieva, A.

Paulsen, K. D.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Pogue, B. W.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Poplack, S. P.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Roy, R. A.

Ruvinskaya, L.

Saint-Jalmes, H.

Sakadzic, S.

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 74, 036618 (2006).
[CrossRef]

R. Zemp, S. Sakadzic, and L.-H. V. Wang, Phys. Rev. E 73, 061920 (2006).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. Lett. 96, 163902 (2006).
[CrossRef] [PubMed]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 72, 036620 (2005).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Opt. Lett. 29, 2770 (2004).
[CrossRef] [PubMed]

Sfez, B. G.

Shafiiha, R.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

Shiokawa, A.

H. Inoue, S. Kudo, and A. Shiokawa, Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 31 (2005).
[CrossRef] [PubMed]

Soho, S.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Srinivasan, S.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Stoica, G.

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Sui, L.

Tosteson, T. D.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Unlu, M. B.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

Wang, L.-H.

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

L.-H. Wang, J. Dis. Mark. 19, 123 (2004).

Wang, L.-H. V.

S. Sakadzic and L.-H. V. Wang, Phys. Rev. Lett. 96, 163902 (2006).
[CrossRef] [PubMed]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 74, 036618 (2006).
[CrossRef]

R. Zemp, S. Sakadzic, and L.-H. V. Wang, Phys. Rev. E 73, 061920 (2006).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 72, 036620 (2005).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Opt. Lett. 29, 2770 (2004).
[CrossRef] [PubMed]

J. Li, G. Ku, and L.-H. V. Wang, Appl. Opt. 41, 6030 (2002).
[CrossRef] [PubMed]

L.-H. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[CrossRef] [PubMed]

G. Marquez and L.-H. V. Wang, Opt. Express 1, 454 (1997).
[CrossRef] [PubMed]

Wang, L-H. V.

Zemp, R.

R. Zemp, S. Sakadzic, and L.-H. V. Wang, Phys. Rev. E 73, 061920 (2006).
[CrossRef]

Zemp, R. J.

Zhang, H. F.

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Zhang, Q.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

Zhao, H.

H. Zhao, X. Gu, and H. Jiang, Opt. Commun. 238, 51 (2004).
[CrossRef]

Appl. Opt. (1)

IEEE Signal Process. Lett. (1)

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).

J. Dis. Mark. (1)

L.-H. Wang, J. Dis. Mark. 19, 123 (2004).

Nat. Biotechnol. (2)

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

J. G. Fujimoto, Nat. Biotechnol. 21, 1361 (2003).
[CrossRef] [PubMed]

Nat. Clin. Pract. Gastroenterol. Hepatol. (1)

H. Inoue, S. Kudo, and A. Shiokawa, Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 31 (2005).
[CrossRef] [PubMed]

Opt. Commun. (1)

H. Zhao, X. Gu, and H. Jiang, Opt. Commun. 238, 51 (2004).
[CrossRef]

Opt. Express (1)

Opt. Lett. (6)

Phys. Rev. E (3)

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 72, 036620 (2005).
[CrossRef]

R. Zemp, S. Sakadzic, and L.-H. V. Wang, Phys. Rev. E 73, 061920 (2006).
[CrossRef]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 74, 036618 (2006).
[CrossRef]

Phys. Rev. Lett. (2)

L.-H. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[CrossRef] [PubMed]

S. Sakadzic and L.-H. V. Wang, Phys. Rev. Lett. 96, 163902 (2006).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003).
[CrossRef] [PubMed]

Technol. Cancer Res. Treat. (1)

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006).
[PubMed]

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Figures (4)

Fig. 1
Fig. 1

Experimental setup: CCD, CCD camera; RF amp, RF amplifier; FG, function generator; PDG, pulse delay generator; T, ultrasound transducer; WT, water tank; S, sample; LT, lens tube; PC, personal computer.

Fig. 2
Fig. 2

(a) Normalized 1D SCC image and total optical intensity (DC) image of one absorbing object ( y = 10 mm ) and one nearly transparent object ( y = 32 mm ) separated by 22 mm . Positions corresponding to both objects are marked with squares. (b) Normalized 1D SCC image and DC image of two scattering objects ( y = 19 mm and y = 41 mm ) separated by 22 mm . Positions corresponding to both objects are marked with squares.

Fig. 3
Fig. 3

Image contrast of different optically scattering objects as a function of μ s .

Fig. 4
Fig. 4

(a) Photograph of two scattering objects having μ s = 30 cm 1 . (b) Corresponding 2D image based on normalized SCC.

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