Abstract

Ultrahigh-resolution adaptive optics–optical coherence tomography (UHR-AO-OCT) instrumentation allowing monochromatic and chromatic aberration correction was used for volumetric in vivo retinal imaging of various retinal structures including the macula and optic nerve head (ONH). Novel visualization methods that simplify AO-OCT data viewing are presented, and include co-registration of AO-OCT volumes with fundus photography and stitching of multiple AO-OCT sub-volumes to create a large field of view (FOV) high-resolution volume. Additionally, we explored the utility of Interactive Science Publishing by linking all presented AO-OCT datasets with the OSA ISP software.

© 2009 Optical Society of America

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    [CrossRef] [PubMed]

2008 (4)

2007 (7)

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

Q1. M. Pircher, R. J. Zawadzki, "Combining adaptive optics with optical coherence tomography: Unveiling the cellular structure of the human retina in vivo," Expert Rev. Ophthalmol. 2, 1019-1035 (2007).
[CrossRef]

W. Drexler and J. G. Fujimoto, "Optical coherence tomography in ophthalmology," J. Biomed. Opt. 12, 041201 (2007).
[CrossRef]

S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, "Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope," J. Opt. Soc. Am. A 24, 1313-1326 (2007).
[CrossRef]

C. E. Bigelow, N. V. Iftimia, R. D. Ferguson, T. E. Ustun, B. Bloom, and D. X. Hammer, "Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging," J. Opt. Soc. Am. A 24, 1327-1336 (2007).
[CrossRef]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Olivier, and J. S. Werner, "Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions," J. Opt. Soc. Am. A 24, 1373-1383 (2007).
[CrossRef]

D. W. Arathorn, Q. Yang, C. R. Vogel, Y. Zhang, P. Tiruveedhula, and A. Roorda, "Retinally stabilized cone-targeted stimulus delivery," Opt. Express 15, 13731-13744 (2007).
[CrossRef] [PubMed]

2006 (7)

C. R. Vogel, D. W. Arathorn, A. Roorda, and A. Parker, "Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy," Opt. Express 14, 487-497 (2006).
[CrossRef] [PubMed]

D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, "Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy," Opt. Express 14, 3345-3353 (2006).
[CrossRef] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006).
[CrossRef] [PubMed]

J. Rha, R. S. Jonnal, K. E. Thorn, J. Qu, Y. Zhang, and D. T. Miller, "Adaptive optics flood-illumination camera for high speed retinal imaging," Opt. Express 14,4552-4569 (2006).
[CrossRef] [PubMed]

D. C. Gray, W. Merigan, J. I. Wolfing, B. P. Gee, J. Porter, A. Dubra, T. H. Twietmeyer, K. Ahamd, R. Tumbar, F. Reinholz, and D. R. Williams, "In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells," Opt. Express 14, 7144-7158 (2006).
[CrossRef] [PubMed]

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

2005 (5)

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Y. Zhang, J. Rha, R. S. Jonnal, and D. T. Miller, "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina," Opt. Express 13, 4792-4811 (2005).
[CrossRef] [PubMed]

E. Fernández and W. Drexler, "Influence of ocular chromatic aberration and pupil size on transverse resolution in ophthalmic adaptive optics optical coherence tomography," Opt. Express 13, 8184-8197 (2005).
[CrossRef] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005).
[CrossRef] [PubMed]

2004 (4)

2003 (2)

W. J. DonnellyIII and A. Roorda, "Optimal pupil size in the human eye for axial resolution," J. Opt. Soc. Am. A 20, 2010-2015 (2003).
[CrossRef]

D. T. Miller, J. Qu, R. S. Jonnal, and K. Thorn, "Coherence gating and adaptive optics in the eye," Proc. SPIE 4956, 65-72 (2003).
[CrossRef]

2002 (2)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

A. Roorda, F. Romero-Borja, W. J. DonnellyIII, H. Queener, T. J. Hebert, and M. C. W. Campbell, "Adaptive optics scanning laser ophthalmoscopy," Opt. Express 10, 405-412 (2002).
[PubMed]

2001 (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

1997 (1)

1995 (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

1993 (2)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18,1864-1866 (1993).
[CrossRef] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Ahamd, K.

Ahnelt, P. K.

Alam, S.

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Anhelt, P.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

Arathorn, D. W.

Artal, P.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

B. Hermann, E. J. Fernandez, A. Unterhubner, H. Sattmann, A. F. Fercher, W. Drexler, P. M. Prieto and P. Artal, "Adaptive-optics ultrahigh-resolution optical coherence tomography," Opt. Lett. 29, 2142-2144 (2004).
[CrossRef] [PubMed]

Bajraszewski, T.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Beaton, S.

Bigelow, C. E.

Bloom, B.

Bouma, B. E.

Bower, B. A.

Bradu, A.

Burns, S. A.

Campbell, M. C. W.

Cense, B.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Chen, T. C.

Choi, S.

Choi, S. S.

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, "Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008).
[CrossRef] [PubMed]

S. S. Choi, R. J. Zawadzki, J. L. Keltner, and J. S. Werner, "Changes in cellular structures revealed by ultrahigh-resolution retinal imaging in optic neuropathies," Invest. Ophthalmol. Vis. Sci. 49, 2103-2119 (2008).
[CrossRef] [PubMed]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Olivier, and J. S. Werner, "Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions," J. Opt. Soc. Am. A 24, 1373-1383 (2007).
[CrossRef]

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Dainty, C.

de Boer, J. F.

Doble, N.

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

Donnelly, W. J.

Drexler, W.

E. J. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, "Ultrahigh-resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina," Opt. Express 16,11083-11094 (2008).
[CrossRef] [PubMed]

W. Drexler and J. G. Fujimoto, "Optical coherence tomography in ophthalmology," J. Biomed. Opt. 12, 041201 (2007).
[CrossRef]

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

E. Fernández and W. Drexler, "Influence of ocular chromatic aberration and pupil size on transverse resolution in ophthalmic adaptive optics optical coherence tomography," Opt. Express 13, 8184-8197 (2005).
[CrossRef] [PubMed]

B. Hermann, E. J. Fernandez, A. Unterhubner, H. Sattmann, A. F. Fercher, W. Drexler, P. M. Prieto and P. Artal, "Adaptive-optics ultrahigh-resolution optical coherence tomography," Opt. Lett. 29, 2142-2144 (2004).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993).
[PubMed]

Dubra, A.

Duker, J.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Duker, J. S.

Elsner, A. E.

Elzaiat, Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

Evans, J. W.

Fercher, A. F.

B. Hermann, E. J. Fernandez, A. Unterhubner, H. Sattmann, A. F. Fercher, W. Drexler, P. M. Prieto and P. Artal, "Adaptive-optics ultrahigh-resolution optical coherence tomography," Opt. Lett. 29, 2142-2144 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993).
[PubMed]

Ferguson, D.

Ferguson, R. D.

Fernandez, E. J.

Fernández, E.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

E. Fernández and W. Drexler, "Influence of ocular chromatic aberration and pupil size on transverse resolution in ophthalmic adaptive optics optical coherence tomography," Opt. Express 13, 8184-8197 (2005).
[CrossRef] [PubMed]

Fernández, E. J.

Flotte, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Fujimoto, J. G.

Fuller, A. R.

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

Gao, W.

Gee, B. P.

Gerth, C.

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Ghanta, R. K.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Gray, D. C.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hamann, B.

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

Hammer, D. X.

Hardy, J. L.

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

Hebert, T. J.

Hee, M. R.

Hermann, B.

Hitzenberger, C. K.

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high- speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993).
[PubMed]

Hofer, B.

Huang, D.

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18,1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Iftimia, N. V.

Izatt, J. A.

Jones, S.

Jones, S. M.

Jonnal, R. S.

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993).
[PubMed]

Kartner, F. X.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Keltner, J. L.

S. S. Choi, R. J. Zawadzki, J. L. Keltner, and J. S. Werner, "Changes in cellular structures revealed by ultrahigh-resolution retinal imaging in optic neuropathies," Invest. Ophthalmol. Vis. Sci. 49, 2103-2119 (2008).
[CrossRef] [PubMed]

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

Ko, T.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Ko, T. H.

Kowalczyk, A.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Laut, S.

Leitgeb, R.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Liang, J.

Lin, C. P.

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18,1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Merigan, W.

Merino, D.

Miller, D. T.

Morgner, U.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Morse, L.

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Nassif, N. A.

Olivier, S.

Olivier, S. S.

Park, B. H.

Park, S. S.

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Parker, A.

Paunescu, L. A.

Pierce, M. C.

Pircher, M.

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high- speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

Q1. M. Pircher, R. J. Zawadzki, "Combining adaptive optics with optical coherence tomography: Unveiling the cellular structure of the human retina in vivo," Expert Rev. Ophthalmol. 2, 1019-1035 (2007).
[CrossRef]

Podoleanu, A. G.

Porter, J.

Povazay, B.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

Považay, B.

Prieto, P.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

Prieto, P. M.

Puliafito, C. A.

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18,1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Qu, J.

Queener, H.

Reinholz, F.

Rha, J.

Romero-Borja, F.

Roorda, A.

Sattman, H.

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

Sattmann, H.

Schuman, J.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Schuman, J. S.

R. D. Ferguson, D. X. Hammer, L. A. Paunescu, S. Beaton, and J. S. Schuman, "Tracking optical coherence tomography," Opt. Lett. 29, 2139-2141 (2004).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18,1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Srinivasan, V. J.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18,1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

Thorn, K.

D. T. Miller, J. Qu, R. S. Jonnal, and K. Thorn, "Coherence gating and adaptive optics in the eye," Proc. SPIE 4956, 65-72 (2003).
[CrossRef]

Thorn, K. E.

Tiruveedhula, P.

Tumbar, R.

Twietmeyer, T. H.

Unterhuber, A.

E. J. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, "Ultrahigh-resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina," Opt. Express 16,11083-11094 (2008).
[CrossRef] [PubMed]

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

Unterhubner, A.

Ustun, T. E.

Vogel, C. R.

Werner, J. S.

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high- speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, "Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008).
[CrossRef] [PubMed]

S. S. Choi, R. J. Zawadzki, J. L. Keltner, and J. S. Werner, "Changes in cellular structures revealed by ultrahigh-resolution retinal imaging in optic neuropathies," Invest. Ophthalmol. Vis. Sci. 49, 2103-2119 (2008).
[CrossRef] [PubMed]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Olivier, and J. S. Werner, "Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions," J. Opt. Soc. Am. A 24, 1373-1383 (2007).
[CrossRef]

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006).
[CrossRef] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005).
[CrossRef] [PubMed]

Wiley, D. F.

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

Williams, D. R.

Wojtkowski, M.

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Wolfing, J. I.

Yang, Q.

Yun, S. H.

Zawadzki, R. J.

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high- speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, "Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008).
[CrossRef] [PubMed]

S. S. Choi, R. J. Zawadzki, J. L. Keltner, and J. S. Werner, "Changes in cellular structures revealed by ultrahigh-resolution retinal imaging in optic neuropathies," Invest. Ophthalmol. Vis. Sci. 49, 2103-2119 (2008).
[CrossRef] [PubMed]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Olivier, and J. S. Werner, "Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions," J. Opt. Soc. Am. A 24, 1373-1383 (2007).
[CrossRef]

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

Q1. M. Pircher, R. J. Zawadzki, "Combining adaptive optics with optical coherence tomography: Unveiling the cellular structure of the human retina in vivo," Expert Rev. Ophthalmol. 2, 1019-1035 (2007).
[CrossRef]

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006).
[CrossRef] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005).
[CrossRef] [PubMed]

Zhang, Y.

Zhao, M.

Am. J. Ophthalmol. (1)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993).
[PubMed]

Expert Rev. Ophthalmol. (1)

Q1. M. Pircher, R. J. Zawadzki, "Combining adaptive optics with optical coherence tomography: Unveiling the cellular structure of the human retina in vivo," Expert Rev. Ophthalmol. 2, 1019-1035 (2007).
[CrossRef]

Invest. Ophthalmol. Vis. Sci. (2)

S. S. Choi, R. J. Zawadzki, J. L. Keltner, and J. S. Werner, "Changes in cellular structures revealed by ultrahigh-resolution retinal imaging in optic neuropathies," Invest. Ophthalmol. Vis. Sci. 49, 2103-2119 (2008).
[CrossRef] [PubMed]

S. S. Choi, N. Doble, J. L. Hardy, S. M. Jones, J. L. Keltner, S. S. Olivier, and J. S. Werner, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function," Invest. Ophthalmol. Vis. Sci. 47, 2080-2092 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt. (3)

W. Drexler and J. G. Fujimoto, "Optical coherence tomography in ophthalmology," J. Biomed. Opt. 12, 041201 (2007).
[CrossRef]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

R. J. Zawadzki, A. R. Fuller, D. F. Wiley, B. Hamann, S. S. Choi, and J. S. Werner, "Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data sets," J. Biomed. Opt. 12, 041206 (2007).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (5)

Nat. Med. (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Ophthalmology (2)

M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006).
[CrossRef] [PubMed]

Opt. Commun. (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

Opt. Express (14)

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

D. C. Gray, W. Merigan, J. I. Wolfing, B. P. Gee, J. Porter, A. Dubra, T. H. Twietmeyer, K. Ahamd, R. Tumbar, F. Reinholz, and D. R. Williams, "In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells," Opt. Express 14, 7144-7158 (2006).
[CrossRef] [PubMed]

A. Roorda, F. Romero-Borja, W. J. DonnellyIII, H. Queener, T. J. Hebert, and M. C. W. Campbell, "Adaptive optics scanning laser ophthalmoscopy," Opt. Express 10, 405-412 (2002).
[PubMed]

J. Rha, R. S. Jonnal, K. E. Thorn, J. Qu, Y. Zhang, and D. T. Miller, "Adaptive optics flood-illumination camera for high speed retinal imaging," Opt. Express 14,4552-4569 (2006).
[CrossRef] [PubMed]

D. W. Arathorn, Q. Yang, C. R. Vogel, Y. Zhang, P. Tiruveedhula, and A. Roorda, "Retinally stabilized cone-targeted stimulus delivery," Opt. Express 15, 13731-13744 (2007).
[CrossRef] [PubMed]

C. R. Vogel, D. W. Arathorn, A. Roorda, and A. Parker, "Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy," Opt. Express 14, 487-497 (2006).
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E. Fernández and W. Drexler, "Influence of ocular chromatic aberration and pupil size on transverse resolution in ophthalmic adaptive optics optical coherence tomography," Opt. Express 13, 8184-8197 (2005).
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R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, "Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008).
[CrossRef] [PubMed]

E. J. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, "Ultrahigh-resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina," Opt. Express 16,11083-11094 (2008).
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D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, "Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy," Opt. Express 14, 3345-3353 (2006).
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Y. Zhang, J. Rha, R. S. Jonnal, and D. T. Miller, "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina," Opt. Express 13, 4792-4811 (2005).
[CrossRef] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005).
[CrossRef] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006).
[CrossRef] [PubMed]

Opt. Lett. (4)

Proc. SPIE (1)

D. T. Miller, J. Qu, R. S. Jonnal, and K. Thorn, "Coherence gating and adaptive optics in the eye," Proc. SPIE 4956, 65-72 (2003).
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991).
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Vision. Res. (1)

E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005).
[CrossRef] [PubMed]

Supplementary Material (4)

» Media 1: AVI (33364 KB)     
» Media 2: AVI (9015 KB)     
» Media 3: AVI (10162 KB)     
» Media 4: AVI (10943 KB)     

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Figures (8)

Fig. 1.
Fig. 1.

An example of AO-OCT scanning areas used for creating larger FOV volume (based on the acquisition of nine sub-volumes). Numbers on the sub-volumes refer to the order in which they were acquired. Fundus photo is used for reference.

Fig. 2.
Fig. 2.

A simple flow chart representing the process of sub-volume co-registration and stitching.

Fig. 3.
Fig. 3.

Left, schematic of the volume manipulation allowed during manual volume stitching in our volume renderer. Right, resulting volume with common voxels.

Fig. 4.
Fig. 4.

Schematic of the manipulation allowed during co-registration of the fundus photo (green rectangle) with the OCT volume.

Fig. 5.
Fig. 5.

UHR-AO-OCT volume of the retinal structures acquired over 0.25×0.3 mm area on the 4.5 deg temporal retina (TR). Top row: left, visualization of the data acquired with UHR-AOOCT system focus set on photoreceptor layers; center, fundus photo with marked location of the acquired volumes; right, visualization of the data acquired with UHR-AO-OCT system focus set on inner retinal layers. Bottom row: left, screenshot from OSA ISP with the UHRAO-OCT volume with focus set on photoreceptor layers (View 1); right, screenshot from OSA ISP with the UHR-AO-OCT volume and focus set on inner retina layers (View 2). Multiple microscopic and cellular structures can be recognized clearly (including photoreceptors seen on the lower left panel and microcapillaries seen on the lower right panel).

Fig. 6.
Fig. 6.

OCT fundus montage created with our volume renderer of nine stitched AO-OCT 1×1 mm sub-volumes acquired with focus set on inner retinal layers.

Fig. 7.
Fig. 7.

Visualization of the large FOV AO-OCT volume (from Fig. 5). Left, movie of the volume with co-registered fundus photo generated with our custom visualization software (Media 1). Right, screenshot from OSA ISP with the slicing plane view of the large FOV AOOCT volume (View 3). Note the clear visualization of microcapillaries and foveal avascular zone when altering the location of the slicing plane.

Fig. 8.
Fig. 8.

Visualization of the ONH microscopic structures imaged with AO-OCT. Left, screenshot from our custom volume renderer after co-registration of five 3D AO-OCT datasets with fundus photo. Right, screenshots from movies showing B-scan and cross-sectional view [26] of three AO-OCT volumes shown on the left: 15N 2SR (Media 2), 12NR (Media 3), and 14N 2IR (Media 4). White lines on the B-scans correspond to the depth of the C-scans reconstructed from the same volume. Multiple microscopic structures including lamina cribosa and blood vessels are easily recognizable. All the volumes can be accessed and viewed with OSA ISP: 12NR (View 4), 14N 2IR (View 5), 15N 2SR (View 6), 17N 1SR (View 7), and 16N 6SR (View 8). Note that the volume acquired at 17N 1SR has motion distortion that could not be properly corrected.

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Tables (1)

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Table 1. Comparison of Volume Acquisition Times and Lateral Sampling for Two Grids

Metrics