Abstract

Raster scanning spectral domain optical coherence tomography (SD-OCT) enables realistic three-dimensional (3D) imaging of macular disease. This approach allows the clinician to investigate the diagnostic situation in detail before and during pharmacological or surgical intervention. This study demonstrates the clinical potential of SD-OCT in chorioretinal disease. Selected datasets are presented to visualize typical morphologic findings, which are identified in more than 2700 patients. Scans are presented as online assessable 3D-models. Clinically relevant structures are visualized in macular disease and highlight the importance of precise imaging, which clearly is a clinical necessity to plan and indicate modern therapeutic strategies for our patients.

© 2009 Optical Society of America

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    [CrossRef]
  31. SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
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    [CrossRef] [PubMed]

2008

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

P. J. Patel, F. K. Chen, L. da Cruz, and A. Tufail, "Segmentation Error in Stratus Optical Coherence Tomography for Neovascular Age-related Macular Degeneration," Invest Ophthalmol Vis Sci. 50,399-404 (2008).
[CrossRef] [PubMed]

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
[CrossRef] [PubMed]

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

W. Drexler, and J. G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res 27,45-88 (2008).
[CrossRef]

Wolf-SchnurrbuschUE , EnzmannV , BrinkmannCK , WolfS  "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination" Invest Ophthalmol Vis Sci. 49,3095-3099 (2008). Epub 2008 Mar 31.
[CrossRef] [PubMed]

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

2007

J. Michalewski, Z. Michalewska, S. Cisiecki, and J. Nawrocki, "Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT)," Graefes Arch Clin Exp Ophthalmol 245,1623-1631 (2007).
[CrossRef] [PubMed]

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog Retin Eye Res 26,57-77 (2007).
[CrossRef]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

G. M. Somfai, H. M. Salinas, C. A. Puliafito, and D. C. Fernandez, "Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation," J Biomed Opt 12,041209 (2007).
[CrossRef] [PubMed]

U. M. Schmidt-Erfurth, and C. Pruente, "Management of neovascular age-related macular degeneration," Prog Retin Eye Res 26,437-451 (2007).
[CrossRef] [PubMed]

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

2006

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

2005

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

N. Villate, J. E. Lee, A. Venkatraman, and W. E. Smiddy, "Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes," Am J Ophthalmol 139,280-289 (2005).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

2003

N. Ferrara, H. P. Gerber, and J. LeCouter, "The biology of VEGF and its receptors," Nat Med 9,669-676 (2003).
[CrossRef] [PubMed]

2002

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

2001

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

1995

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

1991

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Q1. "Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group," Ophthalmology 98,807-822 (1991).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Ahlers, C.

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Augustin, A.

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

Aylward, W. G.

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

Bandello, F.

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

Bhargava, P

SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
[CrossRef] [PubMed]

Bilonick, R. A.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

Blair, N. P.

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Boyer, D. S.

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

Brinkmann, V

Wolf-SchnurrbuschUE , EnzmannV , BrinkmannCK , WolfS  "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination" Invest Ophthalmol Vis Sci. 49,3095-3099 (2008). Epub 2008 Mar 31.
[CrossRef] [PubMed]

Brown, D. M.

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

Bunce, C.

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

Bursell, S. E.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

Campochiaro, P. A.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

Carvalho, M.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

Chan, A.

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Charbel Issa, M

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Chen, F. K.

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

P. J. Patel, F. K. Chen, L. da Cruz, and A. Tufail, "Segmentation Error in Stratus Optical Coherence Tomography for Neovascular Age-related Macular Degeneration," Invest Ophthalmol Vis Sci. 50,399-404 (2008).
[CrossRef] [PubMed]

Cheng, C. Y.

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

Chung, C. Y.

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

Cisiecki, S.

J. Michalewski, Z. Michalewska, S. Cisiecki, and J. Nawrocki, "Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT)," Graefes Arch Clin Exp Ophthalmol 245,1623-1631 (2007).
[CrossRef] [PubMed]

Clermont, A.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

Corcostegui, B.

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

Cortez, R.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

da Cruz, L.

P. J. Patel, F. K. Chen, L. da Cruz, and A. Tufail, "Segmentation Error in Stratus Optical Coherence Tomography for Neovascular Age-related Macular Degeneration," Invest Ophthalmol Vis Sci. 50,399-404 (2008).
[CrossRef] [PubMed]

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

Dastmalchi, S.

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

Davis, J. L.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

de Smet, M. D.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog Retin Eye Res 26,57-77 (2007).
[CrossRef]

Dougall, J.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

Drexler, W.

W. Drexler, and J. G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res 27,45-88 (2008).
[CrossRef]

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Dubovy, S. R.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

Duker, J. S.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

Enzmann, UE

Wolf-SchnurrbuschUE , EnzmannV , BrinkmannCK , WolfS  "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination" Invest Ophthalmol Vis Sci. 49,3095-3099 (2008). Epub 2008 Mar 31.
[CrossRef] [PubMed]

Esquiabro, M.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

Faber, D. J.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog Retin Eye Res 26,57-77 (2007).
[CrossRef]

Fercher, A. F.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Fernandez, D. C.

G. M. Somfai, H. M. Salinas, C. A. Puliafito, and D. C. Fernandez, "Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation," J Biomed Opt 12,041209 (2007).
[CrossRef] [PubMed]

Ferrara, N.

N. Ferrara, H. P. Gerber, and J. LeCouter, "The biology of VEGF and its receptors," Nat Med 9,669-676 (2003).
[CrossRef] [PubMed]

Feuer, W. J.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

Finger, S

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Fleckenstein,

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Flynn, H. W.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

Fous, A.

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

Fujimoto, J. G.

W. Drexler, and J. G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res 27,45-88 (2008).
[CrossRef]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

Fung, A. E.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

Gabriele, M. L.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

Geitzenauer, W.

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

George, L

SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
[CrossRef] [PubMed]

Gerber, H. P.

N. Ferrara, H. P. Gerber, and J. LeCouter, "The biology of VEGF and its receptors," Nat Med 9,669-676 (2003).
[CrossRef] [PubMed]

Golbaz, I.

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

Gotoh, N.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Haller, J. A.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

Hangai, M.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Hee, M. R.

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Heier, J. S.

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

Helb, P

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Hermann, B.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Holz, KU

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Hsu, W. M.

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

Huang, D.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Ikeji, F.

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

Inoue, R.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Ishikawa, H.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

Izatt, J. A.

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

Kagemann, L.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

Kaiser, P. K.

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

Kim, R. Y.

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

Ko, T.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

Ko, T. H.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

Kolar, S.

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

Kowalczyk, A.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

LaBree, L. D.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

Lalwani, G. A.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

LeCouter, J.

N. Ferrara, H. P. Gerber, and J. LeCouter, "The biology of VEGF and its receptors," Nat Med 9,669-676 (2003).
[CrossRef] [PubMed]

Lee, F. L.

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

Lee, J. E.

N. Villate, J. E. Lee, A. Venkatraman, and W. E. Smiddy, "Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes," Am J Ophthalmol 139,280-289 (2005).
[CrossRef] [PubMed]

Leitgeb, R. A.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Lem, J.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

Lin, C. P.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Liu, J. H.

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

Loeffler, HP

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Makita, S.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Michalewska, Z.

J. Michalewski, Z. Michalewska, S. Cisiecki, and J. Nawrocki, "Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT)," Graefes Arch Clin Exp Ophthalmol 245,1623-1631 (2007).
[CrossRef] [PubMed]

Michalewski, J.

J. Michalewski, Z. Michalewska, S. Cisiecki, and J. Nawrocki, "Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT)," Graefes Arch Clin Exp Ophthalmol 245,1623-1631 (2007).
[CrossRef] [PubMed]

Michels, M.

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

Michels, S.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Nawrocki, J.

J. Michalewski, Z. Michalewska, S. Cisiecki, and J. Nawrocki, "Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT)," Graefes Arch Clin Exp Ophthalmol 245,1623-1631 (2007).
[CrossRef] [PubMed]

Ogura, Y.

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Ojima, Y.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Patel, P. J.

P. J. Patel, F. K. Chen, L. da Cruz, and A. Tufail, "Segmentation Error in Stratus Optical Coherence Tomography for Neovascular Age-related Macular Degeneration," Invest Ophthalmol Vis Sci. 50,399-404 (2008).
[CrossRef] [PubMed]

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

Pieroni, C. G.

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

Polito, A.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

Povazay, B.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Pruente, C.

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

U. M. Schmidt-Erfurth, and C. Pruente, "Management of neovascular age-related macular degeneration," Prog Retin Eye Res 26,437-451 (2007).
[CrossRef] [PubMed]

Puliafito, C. A.

G. M. Somfai, H. M. Salinas, C. A. Puliafito, and D. C. Fernandez, "Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation," J Biomed Opt 12,041209 (2007).
[CrossRef] [PubMed]

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Reichel, E.

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

Richard, G.

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

Richine, L.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

Rosenfeld, P. J.

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

P. J. Rosenfeld, D. M. Brown, J. S. Heier, D. S. Boyer, P. K. Kaiser, C. Y. Chung, and R. Y. Kim, "Ranibizumab for neovascular age-related macular degeneration," N Engl J Med 355,1419-1431 (2006).
[CrossRef] [PubMed]

Rusin, M. M.

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Rutledge, B.

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

Sacu, S.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Sadda, S. R.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

Salinas, H. M.

G. M. Somfai, H. M. Salinas, C. A. Puliafito, and D. C. Fernandez, "Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation," J Biomed Opt 12,041209 (2007).
[CrossRef] [PubMed]

Sasahara, M.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Sattmann, H.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Schmidt-Erfurth, U.

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Schmidt-Erfurth, U. M.

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

U. M. Schmidt-Erfurth, and C. Pruente, "Management of neovascular age-related macular degeneration," Prog Retin Eye Res 26,437-451 (2007).
[CrossRef] [PubMed]

Schmitz-Valckenberg, HM

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Schneider, S.

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

Scholda, C.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
[CrossRef] [PubMed]

Scholl, RP

FleckensteinM , Charbel IssaP , HelbHM , Schmitz-ValckenbergS , FingerRP , SchollHP , LoefflerKU , HolzFG . "High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration" Invest Ophthalmol Vis Sci. 49,4137-4144 (2008). Epub 2008 May 16.
[CrossRef] [PubMed]

Schuman, J. S.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Sen,

SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
[CrossRef] [PubMed]

Shah, S. M.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

Shahidi, M.

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Simader, C.

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

Smiddy, W. E.

N. Villate, J. E. Lee, A. Venkatraman, and W. E. Smiddy, "Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes," Am J Ophthalmol 139,280-289 (2005).
[CrossRef] [PubMed]

Somfai, G. M.

G. M. Somfai, H. M. Salinas, C. A. Puliafito, and D. C. Fernandez, "Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation," J Biomed Opt 12,041209 (2007).
[CrossRef] [PubMed]

Song, Q. H.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

Soubrane, G.

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

Srinivasan, V. J.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

Stetson, P.

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Stock, G.

C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
[CrossRef] [PubMed]

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

Swanson, E. A.

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito,  and et al., "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Sy, J. P.

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
[CrossRef] [PubMed]

Tsujikawa, A.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Tufail, A.

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

P. J. Patel, F. K. Chen, L. da Cruz, and A. Tufail, "Segmentation Error in Stratus Optical Coherence Tomography for Neovascular Age-related Macular Degeneration," Invest Ophthalmol Vis Sci. 50,399-404 (2008).
[CrossRef] [PubMed]

van Leeuwen, T. G.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog Retin Eye Res 26,57-77 (2007).
[CrossRef]

van Velthoven, M. E.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog Retin Eye Res 26,57-77 (2007).
[CrossRef]

Venkatraman, A.

N. Villate, J. E. Lee, A. Venkatraman, and W. E. Smiddy, "Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes," Am J Ophthalmol 139,280-289 (2005).
[CrossRef] [PubMed]

Verbraak, F. D.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog Retin Eye Res 26,57-77 (2007).
[CrossRef]

Vijaya, A

SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
[CrossRef] [PubMed]

Villate, N.

N. Villate, J. E. Lee, A. Venkatraman, and W. E. Smiddy, "Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes," Am J Ophthalmol 139,280-289 (2005).
[CrossRef] [PubMed]

Vitale, S.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

Walsh, A. C.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

Witkin, A. J.

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

Wojtkowski, M.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

Wolf, CK

Wolf-SchnurrbuschUE , EnzmannV , BrinkmannCK , WolfS  "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination" Invest Ophthalmol Vis Sci. 49,3095-3099 (2008). Epub 2008 Mar 31.
[CrossRef] [PubMed]

Wolf-Schnurrbusch,

Wolf-SchnurrbuschUE , EnzmannV , BrinkmannCK , WolfS  "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination" Invest Ophthalmol Vis Sci. 49,3095-3099 (2008). Epub 2008 Mar 31.
[CrossRef] [PubMed]

Wollstein, G.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning," Invest Ophthalmol Vis Sci 48,3154-3160 (2007).
[CrossRef] [PubMed]

Wong, C.

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

Wu, Z.

S. R. Sadda, Z. Wu, A. C. Walsh, L. Richine, J. Dougall, R. Cortez, and L. D. LaBree, "Errors in retinal thickness measurements obtained by optical coherence tomography," Ophthalmology 113,285-293 (2006).
[CrossRef] [PubMed]

Xing, W.

P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
[CrossRef] [PubMed]

Yang, C. S.

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

Yasuno, Y.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Yatagai, T.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Yoshimura, N.

Y. Ojima, M. Hangai, M. Sasahara, N. Gotoh, R. Inoue, Y. Yasuno, S. Makita, T. Yatagai, A. Tsujikawa, and N. Yoshimura, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography," Ophthalmology 114,2197-2207 (2007).
[CrossRef] [PubMed]

Zeimer, R.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Zimmer-Galler, I.

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

Acta Ophthalmol Scand

C. S. Yang, C. Y. Cheng, F. L. Lee, W. M. Hsu, and J. H. Liu, "Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography," Acta Ophthalmol Scand 79,266-270 (2001).
[CrossRef] [PubMed]

U. M. Schmidt-Erfurth, G. Richard, A. Augustin, W. G. Aylward, F. Bandello, B. Corcostegui, J. Cunha- Vaz, A. Gaudric, A. Leys, and R. O. Schlingemann, "Guidance for the treatment of neovascular age-related macular degeneration," Acta Ophthalmol Scand 85, 486-494 (2007).
[CrossRef] [PubMed]

Am J Ophthalmol

A. E. Fung, G. A. Lalwani, P. J. Rosenfeld, S. R. Dubovy, S. Michels, W. J. Feuer, C. A. Puliafito, J. L. Davis, H. W. Flynn, Jr., and M. Esquiabro, "An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration," Am J Ophthalmol 143,566-583 (2007).
[CrossRef] [PubMed]

A. Polito, S. M. Shah, J. A. Haller, I. Zimmer-Galler, R. Zeimer, P. A. Campochiaro, and S. Vitale, "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease," Am J Ophthalmol 134,240-251 (2002).
[CrossRef] [PubMed]

N. Villate, J. E. Lee, A. Venkatraman, and W. E. Smiddy, "Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes," Am J Ophthalmol 139,280-289 (2005).
[CrossRef] [PubMed]

Arch Ophthalmol

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113,325-332 (1995).
[PubMed]

M. R. Hee, C. A. Puliafito, C. Wong, J. S. Duker, E. Reichel, B. Rutledge, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Arch Ophthalmol 113,1019-1029 (1995).
[PubMed]

M. Shahidi, Y. Ogura, N. P. Blair, M. M. Rusin, and R. Zeimer, "Retinal thickness analysis for quantitative assessment of diabetic macular edema," Arch Ophthalmol 109,1115-1119 (1991).
[PubMed]

Br J Ophthalmol

C. Ahlers, C. Simader, W. Geitzenauer, G. Stock, P. Stetson, S. Dastmalchi, and U. Schmidt-Erfurth, "Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography," Br J Ophthalmol 92,197-203 (2008).
[CrossRef]

C. G. Pieroni, A. J. Witkin, T. H. Ko, J. G. Fujimoto, A. Chan, J. S. Schuman, H. Ishikawa, E. Reichel, and J. S. Duker, "Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration," Br J Ophthalmol 90,191-197 (2006).
[CrossRef] [PubMed]

Clin Experiment Ophthalmol.

SenP , BhargavaA , VijayaL , GeorgeR , "Prevalence of idiopathic macular hole in adult rural and urban south Indian population" Clin Experiment Ophthalmol. 36,257-260 (2008).
[CrossRef] [PubMed]

Graefes Arch Clin Exp Ophthalmol

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Invest Ophthalmol Vis Sci

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V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography," Invest Ophthalmol Vis Sci 47,5522-5528 (2006).
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P. J. Patel, F. K. Chen, F. Ikeji, W. Xing, C. Bunce, L. Da Cruz, and A. Tufail, "Repeatability of stratus optical coherence tomography measures in neovascular age-related macular degeneration," Invest Ophthalmol Vis Sci 49,1084-1088 (2008).
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U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest Ophthalmol Vis Sci 46,3393-3402 (2005).
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J Biomed Opt

G. M. Somfai, H. M. Salinas, C. A. Puliafito, and D. C. Fernandez, "Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation," J Biomed Opt 12,041209 (2007).
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N Engl J Med

D. M. Brown, P. K. Kaiser, M. Michels, G. Soubrane, J. S. Heier, R. Y. Kim, J. P. Sy, and S. Schneider, "Ranibizumab versus verteporfin for neovascular age-related macular degeneration," N Engl J Med 355,1432-1444 (2006).
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Nat Med

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C. Ahlers, I. Golbaz, G. Stock, A. Fous, S. Kolar, C. Pruente, and U. Schmidt-Erfurth, "Time course of morphologic effects on different retinal compartments after ranibizumab therapy in age-related macular degeneration," Ophthalmology 115,e39-46 (2008).
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M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
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Prog Retin Eye Res

W. Drexler, and J. G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res 27,45-88 (2008).
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Science

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Figures (4)

Fig. 1.
Fig. 1.

Macular Pucker. The configuration of retinal traction and folds can be visualized in 2d and 3d images. The retinal pigment epithelium (RPE) and the external limiting membrane (ELM) are of regular shape. 3D data is available in View 1.

Fig. 2.
Fig. 2.

Macular hole. Details are visualized in View 2. Figure 2a shows the 3D-image, whereas 2b shows the symmetric arrangement of cysts around the macular hole. 3c nicely shows the operculum attached to the vitreus and the central gap in the intraretinal structure. High resolution of SD-OCT imaging allows visualizing discrete features like the external limiting membrane (ELM).

Fig. 3.
Fig. 3.

This figure shows a large detachment of the retinal pigment epithelium (PED). The basis of this PED is of irregular shape (View 3). Zones of significant pigment epithelial atrophy can be observed in View 4.

Fig. 4.
Fig. 4.

This figure demonstrates the typical intraretinal changes in neovascular age-related macular degeneration (nAMD). Subretinal fluid (SRF) has been proven to be a relevant marker for prognosis of nAMD disease and can be observed in distinct locations. 3D-data is available in View 5.

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