Abstract

We demonstrate the necessity of functional and structural a priori information for quantitative fluorescence tomography (FT) with phantom studies. Here the functional a priori information is defined as the optical properties of the heterogeneous background that can be measured by a diffuse optical tomography (DOT) system. A CCD-based noncontact hybrid FT/DOT system that could take measurements at multiple views was built. Multimodality phantoms with multiple compartments were constructed and used in the experiments to mimic a heterogeneous optical background. A 3.6mm diameter object deeply embedded in a heterogeneous optical background could be localized without any a priori information, but the recovered fluorophore concentration only reached one tenth of the true concentration. On the other hand, the true fluorophore concentration could be recovered when both functional and structural a priori information is utilized to guide and constrain the FT reconstruction algorithm.

© 2009 Optical Society of America

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    [CrossRef] [PubMed]

2008

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with structural a priori information: property analysis,” Proc. SPIE 6850, 35 (2008).

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

E. M. Sevick-Muraca and J. C. Rasmussen, “Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine,” J Biomed. Opt. 13, 041303 (2008).
[CrossRef] [PubMed]

Y. Tan and H. Jiang, “Diffuse optical tomography guided quantitative fluorescence molecular tomography,” Appl. Opt. 47, 2011-2016 (2008).
[CrossRef] [PubMed]

2007

M. Guven, K. Kwon, B. Yazici, and V. Ntziachristos, “Fluorescence diffuse optical image reconstruction with a priori information,” Proc. SPIE 6431, 643107 (2007).
[CrossRef]

D. S. Kepshire, S. C. Davis, H. Dehghani, K. D. Paulsen, and B. W. Pogue, “Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth,” Appl. Opt. 46, 1669-1678(2007).
[CrossRef] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15, 4066 (2007).
[CrossRef] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, H. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15, 8043 (2007).
[CrossRef] [PubMed]

L. Hervé, A. Koenig, A. D. Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Appl. Opt. 46, 4896-4906 (2007).
[CrossRef] [PubMed]

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study,” Phys. Med. Biol. 52, 5569-5585 (2007).
[CrossRef] [PubMed]

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

G. Gulsen, M. B. Unlu, O. Birgul, and O. Nalcioglu, “Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system,” Proc. SPIE 6431, 64310D (2007).
[CrossRef]

2006

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

V. Ntziachristos, “Fluorescence molecular imaging,” Annu. Rev. Biomed. Eng. 8, 1-33 (2006).
[CrossRef] [PubMed]

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

2005

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

2004

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

E. E. Graves, R. Weissleder, and V. Ntziachristos, “Fluorescence molecular imaging of small animal tumor models,” Curr. Mol. Med. 4, 419-430 (2004).
[CrossRef] [PubMed]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

2003

E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Med. Phys. 30, 901-911 (2003).
[CrossRef] [PubMed]

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13, 195-208 (2003).
[PubMed]

A. B. Milstein, S. Oh, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, “Fluorescence optical diffusion tomography,” Appl. Opt. 42, 3081-3094 (2003).
[CrossRef] [PubMed]

2001

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

1999

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41-R93 (1999).
[CrossRef]

1997

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42, 841-853 (1997).
[CrossRef] [PubMed]

1994

Achilefu, S.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Alencar, H.

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

Alfano, R. R.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Arridge, S. R.

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41-R93 (1999).
[CrossRef]

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42, 841-853 (1997).
[CrossRef] [PubMed]

Becker, A.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Becker, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Berger, M.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

L. Hervé, A. Koenig, A. D. Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Appl. Opt. 46, 4896-4906 (2007).
[CrossRef] [PubMed]

Birgul, O.

G. Gulsen, M. B. Unlu, O. Birgul, and O. Nalcioglu, “Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system,” Proc. SPIE 6431, 64310D (2007).
[CrossRef]

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

O. Birgul, G. Gulsen, R. Shafiiha, M. B. Unlu, and O. Nalcioglu, “In vivo small animal imaging using combined MR-DOT system,” in Biomedical Optics, Technical Digest (Optical Society of America, 2006), paper TuG1.

G. Gulsen, M. B. Unlu, O. Birgul, H. Yan, and O. Nalcioglu, “A multi-modality system for dynamic imaging of cancer,” in Proceedings of IEEE Conference on International Symposium on Biomedical Imaging (IEEE, 2006), Vol. 3.

Boas, D. A.

A. B. Milstein, S. Oh, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, “Fluorescence optical diffusion tomography,” Appl. Opt. 42, 3081-3094 (2003).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Bordy, T.

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

Bouman, C. A.

Boutet, J.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

L. Hervé, A. Koenig, A. D. Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Appl. Opt. 46, 4896-4906 (2007).
[CrossRef] [PubMed]

Bremer, C.

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13, 195-208 (2003).
[PubMed]

Brooks, D. H.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Carpenter, C. M.

Catana, C.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Chance, B.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Cherry, S. R.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Claussen, C. D.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Coll, J. L.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

Da Silva, A.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

Davis, S. C.

Debourdeau, M.

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

Dehghani, H.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

D. S. Kepshire, S. C. Davis, H. Dehghani, K. D. Paulsen, and B. W. Pogue, “Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth,” Appl. Opt. 46, 1669-1678(2007).
[CrossRef] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, H. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15, 8043 (2007).
[CrossRef] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15, 4066 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

DiMarzio, C. A.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Dinten, J. M.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

L. Hervé, A. Koenig, A. D. Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Appl. Opt. 46, 4896-4906 (2007).
[CrossRef] [PubMed]

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

Ebert, B.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Economou, E. N.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Eichner, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Eppstein, M. J.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Feng, T. C.

Funovics, M. A.

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

Gao, H.

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with structural a priori information: property analysis,” Proc. SPIE 6850, 35 (2008).

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study,” Phys. Med. Biol. 52, 5569-5585 (2007).
[CrossRef] [PubMed]

Garofalakis, A.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Gaudette, R. J.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Gibbs-Strauss, S. L.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Godavarty, A.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Graves, E. E.

E. E. Graves, R. Weissleder, and V. Ntziachristos, “Fluorescence molecular imaging of small animal tumor models,” Curr. Mol. Med. 4, 419-430 (2004).
[CrossRef] [PubMed]

E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Med. Phys. 30, 901-911 (2003).
[CrossRef] [PubMed]

Grotzinger, C.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Gulsen, G.

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with structural a priori information: property analysis,” Proc. SPIE 6850, 35 (2008).

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study,” Phys. Med. Biol. 52, 5569-5585 (2007).
[CrossRef] [PubMed]

G. Gulsen, M. B. Unlu, O. Birgul, and O. Nalcioglu, “Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system,” Proc. SPIE 6431, 64310D (2007).
[CrossRef]

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

O. Birgul, G. Gulsen, R. Shafiiha, M. B. Unlu, and O. Nalcioglu, “In vivo small animal imaging using combined MR-DOT system,” in Biomedical Optics, Technical Digest (Optical Society of America, 2006), paper TuG1.

G. Gulsen, M. B. Unlu, O. Birgul, H. Yan, and O. Nalcioglu, “A multi-modality system for dynamic imaging of cancer,” in Proceedings of IEEE Conference on International Symposium on Biomedical Imaging (IEEE, 2006), Vol. 3.

Gurfinkel, M.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Guven, M.

M. Guven, K. Kwon, B. Yazici, and V. Ntziachristos, “Fluorescence diffuse optical image reconstruction with a priori information,” Proc. SPIE 6431, 643107 (2007).
[CrossRef]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Haskell, R. C.

Hebden, J. C.

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42, 841-853 (1997).
[CrossRef] [PubMed]

Heindel, W.

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

Herve, L.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

Hervé, L.

Hessenius, C.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Intes, X.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Jiang, H.

Jiang, S.

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15, 4066 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Jiang, S. S.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Josserand, V.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

Judenhofer, M. S.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Kepshire, D. S.

Kilmer, M.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Kioussis, D.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Klingel, K.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Kneilling, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Koenig, A.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

L. Hervé, A. Koenig, A. D. Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Appl. Opt. 46, 4896-4906 (2007).
[CrossRef] [PubMed]

Kogel, C.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Kwon, K.

M. Guven, K. Kwon, B. Yazici, and V. Ntziachristos, “Fluorescence diffuse optical image reconstruction with a priori information,” Proc. SPIE 6431, 643107 (2007).
[CrossRef]

Leussler, C.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Licha, K.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Lichy, M. P.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Lin, Y.

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with structural a priori information: property analysis,” Proc. SPIE 6850, 35 (2008).

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study,” Phys. Med. Biol. 52, 5569-5585 (2007).
[CrossRef] [PubMed]

Lombardo, J. M.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Machulla, H. J.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Mahmood, U.

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

Maloux, C.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Mamalaki, C.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Mazurkewitz, P.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

McAdams, M. S.

Meyer, H.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Millane, R. P.

Miller, E. L.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Milstein, A. B.

Montet, X.

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

Nalcioglu, O.

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with structural a priori information: property analysis,” Proc. SPIE 6850, 35 (2008).

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study,” Phys. Med. Biol. 52, 5569-5585 (2007).
[CrossRef] [PubMed]

G. Gulsen, M. B. Unlu, O. Birgul, and O. Nalcioglu, “Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system,” Proc. SPIE 6431, 64310D (2007).
[CrossRef]

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

O. Birgul, G. Gulsen, R. Shafiiha, M. B. Unlu, and O. Nalcioglu, “In vivo small animal imaging using combined MR-DOT system,” in Biomedical Optics, Technical Digest (Optical Society of America, 2006), paper TuG1.

G. Gulsen, M. B. Unlu, O. Birgul, H. Yan, and O. Nalcioglu, “A multi-modality system for dynamic imaging of cancer,” in Proceedings of IEEE Conference on International Symposium on Biomedical Imaging (IEEE, 2006), Vol. 3.

Newport, D. F.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Ntziachristos, V.

M. Guven, K. Kwon, B. Yazici, and V. Ntziachristos, “Fluorescence diffuse optical image reconstruction with a priori information,” Proc. SPIE 6431, 643107 (2007).
[CrossRef]

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

V. Ntziachristos, “Fluorescence molecular imaging,” Annu. Rev. Biomed. Eng. 8, 1-33 (2006).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

E. E. Graves, R. Weissleder, and V. Ntziachristos, “Fluorescence molecular imaging of small animal tumor models,” Curr. Mol. Med. 4, 419-430 (2004).
[CrossRef] [PubMed]

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13, 195-208 (2003).
[PubMed]

E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Med. Phys. 30, 901-911 (2003).
[CrossRef] [PubMed]

A. Serdaroglu, B. Yazici, and V. Ntziachristos, “Fluorescence molecular tomography based on a priori information,” in Biomedical Optics Conference (OSA., 2006)

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” in Proceedings of IEEE Conference on Translational Medical Imaging (IEEE2004), pp. 492-500.
[CrossRef]

Nutt, R. E.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Oh, S.

Papamatheakis, J.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Paulsen, K. D.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

D. S. Kepshire, S. C. Davis, H. Dehghani, K. D. Paulsen, and B. W. Pogue, “Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth,” Appl. Opt. 46, 1669-1678(2007).
[CrossRef] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, H. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15, 8043 (2007).
[CrossRef] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15, 4066 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Peltie, P.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

Peltié, P.

Peters, S.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Pichler, B. J.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Pogue, B. W.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

D. S. Kepshire, S. C. Davis, H. Dehghani, K. D. Paulsen, and B. W. Pogue, “Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth,” Appl. Opt. 46, 1669-1678(2007).
[CrossRef] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, H. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15, 8043 (2007).
[CrossRef] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15, 4066 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Poplack, S. P.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Pu, Y.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Rasmussen, J. C.

E. M. Sevick-Muraca and J. C. Rasmussen, “Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine,” J Biomed. Opt. 13, 041303 (2008).
[CrossRef] [PubMed]

Reischl, G.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Ripoll, J.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Med. Phys. 30, 901-911 (2003).
[CrossRef] [PubMed]

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” in Proceedings of IEEE Conference on Translational Medical Imaging (IEEE2004), pp. 492-500.
[CrossRef]

Rizo, P.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

L. Hervé, A. Koenig, A. D. Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Appl. Opt. 46, 4896-4906 (2007).
[CrossRef] [PubMed]

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

Rocken, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Roy, R.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Sawczuk, I.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Schulz, R. B.

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” in Proceedings of IEEE Conference on Translational Medical Imaging (IEEE2004), pp. 492-500.
[CrossRef]

Semmler, W.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Serdaroglu, A.

A. Serdaroglu, B. Yazici, and V. Ntziachristos, “Fluorescence molecular tomography based on a priori information,” in Biomedical Optics Conference (OSA., 2006)

Sevick-Muraca, E. M.

E. M. Sevick-Muraca and J. C. Rasmussen, “Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine,” J Biomed. Opt. 13, 041303 (2008).
[CrossRef] [PubMed]

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Shafiiha, R.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

O. Birgul, G. Gulsen, R. Shafiiha, M. B. Unlu, and O. Nalcioglu, “In vivo small animal imaging using combined MR-DOT system,” in Biomedical Optics, Technical Digest (Optical Society of America, 2006), paper TuG1.

Siegel, S. B.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Silva, A. D.

Springett, R.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Srinivasan, S.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

Sukowski, U.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Svaasand, L. O.

Tan, Y.

Tang, G. C.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Theilmeier, G.

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

Thielscher, A.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Thompson, A. B.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Tosteson, T. D.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

Tromberg, B. J.

Tsay, T.

Tuttle, S. B.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Uludag, K.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Unlu, M. B.

G. Gulsen, M. B. Unlu, O. Birgul, and O. Nalcioglu, “Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system,” Proc. SPIE 6431, 64310D (2007).
[CrossRef]

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

O. Birgul, G. Gulsen, R. Shafiiha, M. B. Unlu, and O. Nalcioglu, “In vivo small animal imaging using combined MR-DOT system,” in Biomedical Optics, Technical Digest (Optical Society of America, 2006), paper TuG1.

G. Gulsen, M. B. Unlu, O. Birgul, H. Yan, and O. Nalcioglu, “A multi-modality system for dynamic imaging of cancer,” in Proceedings of IEEE Conference on International Symposium on Biomedical Imaging (IEEE, 2006), Vol. 3.

Vitenson, J. H.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Wang, J.

Wang, L. V.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

Wang, W. B.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Weaver, J.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

Webb, K. J.

Wehrl, H. F.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Weissleder, R.

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

E. E. Graves, R. Weissleder, and V. Ntziachristos, “Fluorescence molecular imaging of small animal tumor models,” Curr. Mol. Med. 4, 419-430 (2004).
[CrossRef] [PubMed]

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13, 195-208 (2003).
[PubMed]

E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Med. Phys. 30, 901-911 (2003).
[CrossRef] [PubMed]

Weitkamp, B.

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

Widmaier, S.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Wiedenmann, B.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

Yalavarthy, P. K.

Yan, H.

G. Gulsen, M. B. Unlu, O. Birgul, H. Yan, and O. Nalcioglu, “A multi-modality system for dynamic imaging of cancer,” in Proceedings of IEEE Conference on International Symposium on Biomedical Imaging (IEEE, 2006), Vol. 3.

Yazici, B.

M. Guven, K. Kwon, B. Yazici, and V. Ntziachristos, “Fluorescence diffuse optical image reconstruction with a priori information,” Proc. SPIE 6431, 643107 (2007).
[CrossRef]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

A. Serdaroglu, B. Yazici, and V. Ntziachristos, “Fluorescence molecular tomography based on a priori information,” in Biomedical Optics Conference (OSA., 2006)

Zacharakis, G.

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Zeng, F.

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Zhang, C.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

Zhang, Q.

A. B. Milstein, S. Oh, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, “Fluorescence optical diffusion tomography,” Appl. Opt. 42, 3081-3094 (2003).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Annu. Rev. Biomed. Eng.

V. Ntziachristos, “Fluorescence molecular imaging,” Annu. Rev. Biomed. Eng. 8, 1-33 (2006).
[CrossRef] [PubMed]

Appl. Opt.

Curr. Mol. Med.

E. E. Graves, R. Weissleder, and V. Ntziachristos, “Fluorescence molecular imaging of small animal tumor models,” Curr. Mol. Med. 4, 419-430 (2004).
[CrossRef] [PubMed]

Eur. Radiol.

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13, 195-208 (2003).
[PubMed]

Gastrointest. Endosc.

M. A. Funovics, H. Alencar, X. Montet, R. Weissleder, and U. Mahmood, “Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization,” Gastrointest. Endosc. 64, 589-597 (2006).
[CrossRef] [PubMed]

IEEE Signal Process. Mag.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57-75 (2001).
[CrossRef]

Inverse Probl.

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41-R93 (1999).
[CrossRef]

Invest. Radiol.

C. Bremer, V. Ntziachristos, B. Weitkamp, G. Theilmeier, W. Heindel, and R. Weissleder, “Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes,” Invest. Radiol. 40, 321-327 (2005).
[CrossRef] [PubMed]

J Biomed. Opt.

E. M. Sevick-Muraca and J. C. Rasmussen, “Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine,” J Biomed. Opt. 13, 041303 (2008).
[CrossRef] [PubMed]

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, “Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography,” J Biomed. Opt. 9, 488-496 (2004).
[CrossRef] [PubMed]

J. Biomed. Opt.

A. Koenig, L. Herve, V. Josserand, M. Berger, J. Boutet, A. Da Silva, J. M. Dinten, P. Peltie, J. L. Coll, and P. Rizo, “In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography,” J. Biomed. Opt. 13, 011008 (2008).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10, 051504 (2005).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A

Med. Phys.

E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Med. Phys. 30, 901-911 (2003).
[CrossRef] [PubMed]

Mol. Imaging

A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, “Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography,” Mol. Imaging 6, 96-107 (2007).
[PubMed]

Nat. Biotechnol.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grotzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19, 327-331 (2001).
[CrossRef] [PubMed]

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23, 313-320 (2005).
[CrossRef] [PubMed]

Nat. Med.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous PET-MRI: a new approach for functional and morphological imaging,” Nat. Med. 14, 459-465 (2008).
[CrossRef] [PubMed]

Opt. Express

Phys. Med. Biol.

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study,” Phys. Med. Biol. 52, 5569-5585 (2007).
[CrossRef] [PubMed]

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42, 841-853 (1997).
[CrossRef] [PubMed]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103, 8828-8833 (2006).
[CrossRef] [PubMed]

Proc. SPIE

G. Gulsen, M. B. Unlu, O. Birgul, and O. Nalcioglu, “Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system,” Proc. SPIE 6431, 64310D (2007).
[CrossRef]

Y. Lin, H. Gao, O. Nalcioglu, and G. Gulsen, “Fluorescence diffuse optical tomography with structural a priori information: property analysis,” Proc. SPIE 6850, 35 (2008).

M. Guven, K. Kwon, B. Yazici, and V. Ntziachristos, “Fluorescence diffuse optical image reconstruction with a priori information,” Proc. SPIE 6431, 643107 (2007).
[CrossRef]

Rev. Sci. Instrum.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Technol. Cancer. Res. Treat.

G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, “Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals,” Technol. Cancer. Res. Treat. 5, 351-363 (2006).
[PubMed]

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, and R. R. Alfano, “Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent,” Technol. Cancer. Res. Treat. 4, 429-436 (2005).
[PubMed]

Other

O. Birgul, G. Gulsen, R. Shafiiha, M. B. Unlu, and O. Nalcioglu, “In vivo small animal imaging using combined MR-DOT system,” in Biomedical Optics, Technical Digest (Optical Society of America, 2006), paper TuG1.

G. Gulsen, M. B. Unlu, O. Birgul, H. Yan, and O. Nalcioglu, “A multi-modality system for dynamic imaging of cancer,” in Proceedings of IEEE Conference on International Symposium on Biomedical Imaging (IEEE, 2006), Vol. 3.

A. Serdaroglu, B. Yazici, and V. Ntziachristos, “Fluorescence molecular tomography based on a priori information,” in Biomedical Optics Conference (OSA., 2006)

A. Da Silva, T. Bordy, M. Debourdeau, J. M. Dinten, P. Peltie, and P. Rizo, “Coupling x-ray and optical tomography systems for in vivo examination of small animals,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (IEEE, 2007), pp. 3335-3338.

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” in Proceedings of IEEE Conference on Translational Medical Imaging (IEEE2004), pp. 492-500.
[CrossRef]

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Figures (5)

Fig. 1
Fig. 1

(a) Photograph of the setup (top view). The CCD camera is on the left-hand side, the cylindrical phantom is placed on a rotation stage, and the phantom is illuminated from one of the three source positions, indicated by arrows. (b) Schematic showing the fiber-optic switch used to illuminate the object (P) from any one of three different positions (L1, L2, and L3). It also allows the selection of either the emission ( λm ) or the excitation ( λx ) wavelength.

Fig. 2
Fig. 2

(a) Schematic showing the 3.6 mm diameter object located 10 mm away from the center of the medium. (b) Schematic showing the three source positions 45 ° apart from each other (indicated in red numbers). The 21 detectors are equally distributed at the boundaries (indicated in green numbers). (c) Reconstructed fluorophore concentration map for Case 1 without the guidance of structural a priori information. Please note that the absorption coefficient of the homogeneous background is found from the DOT measurements and is used as the functional a priori information. (d) Reconstructed fluorophore concentration map for Case 1 when the structural a priori information is utilized. (e), (f) Reconstructed fluorophore concentration map when the object size is underestimated by 10% and the object location is estimated 3 mm off from the structural images, respectively.

Fig. 3
Fig. 3

First column is the T1 weighted MR images of the phantoms for phantom study Cases 2 and 3. The fluorophore is held by a transparent tube with 0.5 mm wall thickness (dark circle shown in MR image). The middle column is the plot of the profile along the x axis across the fluorescence object (as indicated by the dashed line in the MR images). The absorption maps at 785 nm are displayed in the third column.

Fig. 4
Fig. 4

Phantom study results for Case 2. The reconstructed fluorophore concentration maps are shown in the left column when (a) using erroneous absorption coefficient and disregarding the background heterogeneity; (b) using reconstructed absorption map from DOT measurement as the functional a priori information in the FT reconstruction; (c) using erroneous absorption coefficient, disregarding the background heterogeneity, and using only the structural a priori information for FT reconstruction; and (d) using reconstructed absorption map as the functional a priori information and applying the structural a priori information during the FT reconstruction. The right column is the plot of the profile along the x axis across the fluorescence object (as indicated by the dashed line in the reconstructed map).

Fig. 5
Fig. 5

Phantom study results for Case 3. The reconstructed fluorophore concentration maps are shown in the left column when (a) using erroneous absorption coefficient and disregarding the background heterogeneity; (b) using reconstructed absorption map from DOT measurement as the functional a priori information in the FT reconstruction; (c) using erroneous absorption coefficient, disregarding the background heterogeneity, and using only the structural a priori information for FT reconstruction; (d) using reconstructed absorption map as the functional a priori information and applying the structural a priori information during the FT reconstruction. The right column is the plot of the profile along the x axis across the fluorescence object (as indicated by the dashed line in the reconstructed map).

Tables (1)

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Table 1 Phantom Study Results for Cases 2 and 3 a

Equations (12)

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· [ D x ( r ) Φ x ( r ) ] [ μ a x ( r ) + μ a f ( r ) ] Φ x ( r ) = q 0 ( r ) ,
· [ D m ( r ) Φ m ( r ) ] [ μ a m ( r ) ] Φ m ( r ) = Φ x ( r ) η μ a f ( r ) ,
Φ x , m ( r ) + 2 A D x , m ( r ) Φ x , m ( r ) n = 0 ,
Ω d x φ · ( D x Φ x ) + Ω d x ( μ a x + μ a f ) φ Φ x + 1 2 A Ω d s φ Φ x = Ω d x φ q 0 ,
Ω d x φ · ( D m Φ m ) + Ω d x ( μ a m ) φ Φ m + 1 2 A Ω d s φ Φ m = Ω d x φ η μ a f Φ x ,
( A x + B x + C ) ξ x = Q x , ( A m + C ) ξ m = Q m ξ x ,
( A x ) i j = k = 1 N D x , k Ω d x φ k ( φ i φ j ) + k = 1 N μ x , k Ω d x φ k ( φ i φ j ) ( B x ) i j = k = 1 N μ a f , k Ω d x φ k ( φ i φ j ) ( C ) i j = Ω d s ( φ i φ j ) ( A m ) i j = k = 1 N D m , k Ω d x φ k ( φ i φ j ) + k = 1 N μ m , k Ω d x φ k ( φ i φ j ) ( Q x ) i = Ω d x ( φ i q 0 ) ( Q m ) i j = k = 1 N μ a f , k Ω d x η φ k ( φ i φ j ) ,
ε 2 ( μ a ) = i = 1 N s j = 1 N d ( ϕ i j m P i j ( μ a ) ) 2 ,
ε 2 ( μ a f ) = i = 1 N s j = 1 N d ( ϕ i j m P i j ( μ a f ) ) 2 ,
X m + 1 = X m + ( J T J + λ I ) 1 ( J T ε ) ,
L i j = { 0 if   i   and   j   are not in the same region 1 / N r i   and   j   are in the same region 1 if   i = j ,
X m + 1 = X m + ( J T J + λ L T L ) 1 ( J T ε ) .

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