Abstract

Laser-induced breakdown spectroscopy (LIBS), which is an excellent tool for trace elemental analysis, was studied as a method of detecting sub-part-per-106 (ppm) concentrations of aluminum in surrogates of human tissue. Tissue was modeled using a 2% agarose gelatin doped with an Al2O3 nanoparticle suspension. A calibration curve created with standard reference samples of known Al concentrations was used to determine the limit of detection, which was less than 1 ppm. Rates of false negative and false positive detection results for a much more realistic sampling methodology were also studied, suggesting that LIBS could be a candidate for the real-time in vivo detection of metal contamination in human soft tissue.

© 2007 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Laser-induced breakdown spectroscopy for the classification of unknown powders

Emily Gibb Snyder, Chase A. Munson, Jennifer L. Gottfried, Frank C. De Lucia, Jr., Brian Gullett, and Andrzej Miziolek
Appl. Opt. 47(31) G80-G87 (2008)

Evaluation criterion of thermal light ghost imaging based on the receiver operating characteristic analysis

Wen-Kai Yu, Xu-Ri Yao, Xue-Feng Liu, Long-Zhen Li, and Guang-Jie Zhai
J. Opt. Soc. Am. A 32(6) 1084-1091 (2015)

Multivariate analysis of standoff laser-induced breakdown spectroscopy spectra for classification of explosive-containing residues

Frank C. De Lucia, Jr., Jennifer L. Gottfried, Chase A. Munson, and Andrzej W. Miziolek
Appl. Opt. 47(31) G112-G121 (2008)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (7)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription