Abstract
The reflection resonance spectrum of a subwavelength diffraction-grating-coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this resonance wavelength shift, the optical waveguide biosensor provides the ability to identify the kinetics of the biomolecular interaction on an on-line basis without the need for extrinsic labeling of the biomolecules. A theoretical analysis of the subwavelength optical waveguide biosensor is performed. A biosensor with a narrow reflection resonance spectrum, and hence an enhanced detection resolution, is then designed and fabricated. Currently, the detection limit of the optical waveguide sensor is approximately refractive-index units. The biosensor is successfully applied to study of the dynamic response of an antibody interaction with protein G adsorbed on the sensing surface.
© 2006 Optical Society of America
Full Article | PDF ArticleMore Like This
F.-C. Chien and S.-J. Chen
Opt. Lett. 31(2) 187-189 (2006)
Jongcheol Hong, Kyung-Hyun Kim, Jae-Heon Shin, Chul Huh, and Gun Yong Sung
Opt. Express 15(14) 8972-8978 (2007)
Hai Yan, Lijun Huang, Xiaochuan Xu, Swapnajit Chakravarty, Naimei Tang, Huiping Tian, and Ray T. Chen
Opt. Express 24(26) 29724-29733 (2016)