Abstract

We describe a photoacoustic image reconstruction algorithm that is based on the finite-element solution to the photoacoustic wave equation in the frequency domain. Our reconstruction approach is an iterative Newton method coupled with combined Marquardt and Tikhonov regularizations that can extract the spatial distribution of optical-absorption property in heterogeneous media. We demonstrate this algorithm by using phantom and chicken bone measurements from a circular scanning photoacoustic tomography system. The results obtained show that millimeter-sized phantom objects and chicken bones and∕or joints can be clearly detected using our finite-element-based photoacoustic tomography method.

© 2006 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
    [CrossRef]
  2. A. A. Karabutov, E. Savateeva, and A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," in Proc. SPIE 3601, 284-295 (1999).
    [CrossRef]
  3. J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
    [CrossRef] [PubMed]
  4. X. Wang, Y. Peng, G. Ku, G. Stoica, and L. Wang, "Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact," Opt. Lett. 28, 1739-1741 (2003).
    [CrossRef] [PubMed]
  5. R. A. Kruger, D. Reinecke, and G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837 (1999).
    [CrossRef] [PubMed]
  6. P. Liu, "The P-transform and photoacoustic image reconstruction," Phys. Med. Biol. 43, 667-674 (1998).
    [CrossRef] [PubMed]
  7. K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
    [CrossRef]
  8. G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
    [CrossRef] [PubMed]
  9. X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
    [CrossRef]
  10. S. J. Norton and T. Vo-Dinh, "Optoacoustic diffraction tomography: analysis of algorithms," J. Opt. Soc. Am. A 20, 1859-1866 (2003).
    [CrossRef]
  11. A. C. Tam, "Applications of photoacoustic sensing techniques," Rev. Mod. Phys. 58, 381-430 (1986).
    [CrossRef]
  12. J. M. Jin, The Finite Element Method in Electromagnetics (Wiley, 2002).
  13. X. Gu, Y. Xu, and H. Jiang, "Mesh-based enhancement schemes in diffuse optical tomography," Med. Phys. 30, 861-869 (2003).
    [CrossRef] [PubMed]
  14. Y. Xu, N. Iftimia, H. Jiang, L. Key, and M. Bolster, "Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography," Opt. Express 8, 447-451 (2001).
    [CrossRef] [PubMed]
  15. A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
    [CrossRef]

2005 (1)

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

2003 (3)

2002 (3)

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
[CrossRef] [PubMed]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

2001 (2)

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Y. Xu, N. Iftimia, H. Jiang, L. Key, and M. Bolster, "Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography," Opt. Express 8, 447-451 (2001).
[CrossRef] [PubMed]

1999 (3)

R. A. Kruger, D. Reinecke, and G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837 (1999).
[CrossRef] [PubMed]

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

A. A. Karabutov, E. Savateeva, and A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," in Proc. SPIE 3601, 284-295 (1999).
[CrossRef]

1998 (1)

P. Liu, "The P-transform and photoacoustic image reconstruction," Phys. Med. Biol. 43, 667-674 (1998).
[CrossRef] [PubMed]

1986 (1)

A. C. Tam, "Applications of photoacoustic sensing techniques," Rev. Mod. Phys. 58, 381-430 (1986).
[CrossRef]

Andreev, V.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Au, G.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Backhaus, M.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Beuthan, J.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Bolster, M.

Burmester, G.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Chen, Z.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Esenaliev, R.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Fleming, D.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Frauchiger, D.

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Frenz, M.

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Fry, E.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Gatalica, Z.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Gu, X.

X. Gu, Y. Xu, and H. Jiang, "Mesh-based enhancement schemes in diffuse optical tomography," Med. Phys. 30, 861-869 (2003).
[CrossRef] [PubMed]

Hermann, K.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Hielscher, A.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Iftimia, N.

Jacques, S.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
[CrossRef] [PubMed]

Jiang, H.

Jin, J. M.

J. M. Jin, The Finite Element Method in Electromagnetics (Wiley, 2002).

Karabutov, A.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Karabutov, A. A.

A. A. Karabutov, E. Savateeva, and A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," in Proc. SPIE 3601, 284-295 (1999).
[CrossRef]

Key, L.

Klose, A.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Kostli, K. P.

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Kruger, G.

R. A. Kruger, D. Reinecke, and G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837 (1999).
[CrossRef] [PubMed]

Kruger, R. A.

R. A. Kruger, D. Reinecke, and G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837 (1999).
[CrossRef] [PubMed]

Ku, G.

Liu, P.

P. Liu, "The P-transform and photoacoustic image reconstruction," Phys. Med. Biol. 43, 667-674 (1998).
[CrossRef] [PubMed]

Moa-Anderson, B.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Muller, G.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Nelson, J.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Netz, U.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Niederhauser, J.

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Norton, S. J.

Oraevsky, A.

A. A. Karabutov, E. Savateeva, and A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," in Proc. SPIE 3601, 284-295 (1999).
[CrossRef]

Oraevsky, A. A.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Paltauf, G.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
[CrossRef] [PubMed]

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Peng, Y.

Prahl, S.

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
[CrossRef] [PubMed]

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Reinecke, D.

R. A. Kruger, D. Reinecke, and G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837 (1999).
[CrossRef] [PubMed]

Ren, H.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Savateeva, E.

A. A. Karabutov, E. Savateeva, and A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," in Proc. SPIE 3601, 284-295 (1999).
[CrossRef]

Scheel, A. K.

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

Singh, H.

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Stoica, G.

Tam, A. C.

A. C. Tam, "Applications of photoacoustic sensing techniques," Rev. Mod. Phys. 58, 381-430 (1986).
[CrossRef]

Viator, J.

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
[CrossRef] [PubMed]

Viator, J. A.

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Vo-Dinh, T.

Wang, L.

X. Wang, Y. Peng, G. Ku, G. Stoica, and L. Wang, "Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact," Opt. Lett. 28, 1739-1741 (2003).
[CrossRef] [PubMed]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Wang, X.

X. Wang, Y. Peng, G. Ku, G. Stoica, and L. Wang, "Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact," Opt. Lett. 28, 1739-1741 (2003).
[CrossRef] [PubMed]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Weber, H.

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

Xu, M.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Xu, Y.

X. Gu, Y. Xu, and H. Jiang, "Mesh-based enhancement schemes in diffuse optical tomography," Med. Phys. 30, 861-869 (2003).
[CrossRef] [PubMed]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Y. Xu, N. Iftimia, H. Jiang, L. Key, and M. Bolster, "Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography," Opt. Express 8, 447-451 (2001).
[CrossRef] [PubMed]

Yokoo, S.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Ann. Rheum. Dis. (1)

A. K. Scheel, M. Backhaus, A. Klose, B. Moa-Anderson, U. Netz, K. Hermann, J. Beuthan, G. Muller, G. Burmester, and A. Hielscher, "First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Ann. Rheum. Dis. 64, 239-245 (2005).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

K. P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, and M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron. 7, 918-923 (2001).
[CrossRef]

J. Acoust. Soc. Am. (1)

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544 (2002).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Lasers Surg. Med. (1)

J. A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, and J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148 (2002).
[CrossRef] [PubMed]

Med. Phys. (3)

R. A. Kruger, D. Reinecke, and G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837 (1999).
[CrossRef] [PubMed]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, and L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

X. Gu, Y. Xu, and H. Jiang, "Mesh-based enhancement schemes in diffuse optical tomography," Med. Phys. 30, 861-869 (2003).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (1)

Phys. Med. Biol. (1)

P. Liu, "The P-transform and photoacoustic image reconstruction," Phys. Med. Biol. 43, 667-674 (1998).
[CrossRef] [PubMed]

Proc. SPIE (2)

A. A. Oraevsky, V. Andreev, A. Karabutov, D. Fleming, Z. Gatalica, H. Singh, and R. Esenaliev, "Laser opto-acoustic imaging of the breast: detection of cancer angiogensis," in Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

A. A. Karabutov, E. Savateeva, and A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," in Proc. SPIE 3601, 284-295 (1999).
[CrossRef]

Rev. Mod. Phys. (1)

A. C. Tam, "Applications of photoacoustic sensing techniques," Rev. Mod. Phys. 58, 381-430 (1986).
[CrossRef]

Other (1)

J. M. Jin, The Finite Element Method in Electromagnetics (Wiley, 2002).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1

Schematic of the photoacoustic tomography system. BS, beam splitter; PC, personal computer.

Fig. 2
Fig. 2

Measured acoustic signal in the temporal domain for the two-target rubber test for a typical detector position. Y axis, acoustic pressure in relative scale; X axis, time.

Fig. 3
Fig. 3

(a), (c), (e) Test geometry of the phantom experiments where dimensional units are in millimeters. The transducer path was along a circle of 60 mm in diameter for the one-target cases, while the path was along a circle of 110.6 mm in diameter for the two-target cases. (b), (d), (f) Reconstructed photoacoustic images for the one- and two-target cases.

Fig. 4
Fig. 4

Recovered parameter profiles along transect AB [see Figs. 3(a), 3(c), and 3(e)] for the images shown in Figs. 3(b), 3(d), and 3(f), respectively.

Fig. 5
Fig. 5

(a), (c) Test geometry of the chicken bone experiments. The transducer path was along a circle of 110 mm in diameter for both cases. (b), (d) Reconstructed photoacoustic images for two pairs of chicken bones.

Equations (17)

Equations on this page are rendered with MathJax. Learn more.

2 p ( r , k ) + k 2 p ( r , k ) = i k β c Φ ( r ) C p ,
p = i = 1 N p i ϕ i , Φ = i = 1 N Φ i ϕ i ,
V ϕ i ( 2 p + k 2 p ) d V - V ϕ i ( i k β c Φ / C p ) d V = 0 ,
A p = b Φ ,
a m n = V ( ϕ m · ϕ n - k 2 ϕ m ϕ n ) d V + Γ ( - ϕ m ϕ n · n ^ ) d Γ ;
b m n = V ( - i k β c ϕ m ϕ n / C p ) d V ,
Φ = { Φ r , 1 , Φ i , 1 , Φ r , 2 , Φ i , 2 , , Φ r , N , Φ i , N } T ,
p = { p r , 1 , p i , 1 , p r , 2 , p i , 2 , , p r , N , p i , N } T ,
ϕ n · n ^ = ηϕ n + γ 2 ϕ n 2 θ ,
p o = p c + p c Φ r ΔΦ r + p c Φ i ΔΦ i + .
I χ = p o - p c ,
I = [ p 1 Φ R , 1 p 1 Φ R , n p 1 Φ I , 1 p 1 Φ I , n p 2 Φ R , 1 p 2 Φ R , n p 2 Φ I , 1 p 2 Φ I , n p M Φ R , 1 p M Φ R , n p M Φ I , 1 p M Φ I , n ] .
[ A R - A I A I A R ] [ p R Φ R p I Φ I ] = [ 0 - B I Φ R B I Φ R 0 ] [ 1 0 ] ,
[ A R - A I A I A R ] [ p R Φ I p I Φ I ] = [ 0 - B I Φ I B I Φ I 0 ] [ 0 1 ] .
( I T I + λ I ) Δχ = I T ( p o - p c ) ,
Φ R ( x i , y i ) = n = 1 3 Φ R , L n Ψ L n ( x , y ) ,
Φ I ( x i , y i ) = n = 1 3 Φ I , L n Ψ L n ( x , y ) ,

Metrics