An innovative optofluidic technique, developed by the authors of this recent Biomedical Optics Express article, allows rapid pre-concentration of small objects bypassing the need to culture the bacteria. To achieve this goal, the authors propose using a local temperature gradient on the surface of a microscope slide with the biosample, created by a laser beam waist of micron size. This gradient produces convection flow of fluid, which manipulates micro-objects, such as bacteria, to form a population with high concentration.
Additionally, this technique enables controlling the size of manipulated particles by adjusting the power of the laser beam, which, in turn, allows for the selective capture of bacterial cells from different biological samples for optional further antibiotic analysis.
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