The importance of Raman spectroscopy in biomedical research is well recognized. It is difficult to find an area of biomedical studies where this technique in not yet used. This role is mostly played due to the ability of Raman spectroscopy to probe the biochemical composition of the investigated object, as well as to receive information about spatial conformation of its macromolecular components. For instance, osteoporosis, the most common skeletal disease, is characterized in large part by the degeneration of articular cartilage, which results from collagen structure disorder. Alignment changes of collagen at the cartilage surface, where the collagen fibers are highly organized in the case of normal tissue, can be identified by polarized Raman scattering. The authors of the paper, recently published in Optics Letters, demonstrate this potential of Raman spectroscopy by reporting the results of successful employment of a multiplexed polarized hypodermic Raman needle probe for the biostructural analysis of articular cartilage. According to the results, this technique may have further applications for diagnosis of a broad range of diseases, which are characterized by collagen structure disorder.
You must log in
to add comments.