Abstract

Quantitative phase microscopy (QPM) has emerged as an important tool for material metrology and biological imaging. For broader adoption in those applications, we have proposed and demonstrated a new portable off-axis QPM method, which works in both transmission and reflection modes to meet different sample measurement requirements. The temporal and spatial sensitivities of our system, as quantified by optical path-length difference values, are 0.65 nm and 1.04 nm, respectively. To demonstrate its applicability for a wide range of applications, we deployed our system for profiling transistor gold electrode samples, observing red blood cell membrane fluctuations, imaging living cells flowing in a microfluidic chip, etc. Our portable QPM system has a low-cost design and involves a simple and robust phase-retrieval algorithm that we envision will allow for broader deployment at different environmental settings, including in resource-limited sites and integration with other metrology or imaging modalities.

© 2020 Chinese Laser Press

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    [Crossref]

2020 (1)

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

2019 (1)

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

2018 (2)

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12, 578–589 (2018).
[Crossref]

2017 (5)

H. Majeed, S. Sridharan, M. Mir, L. H. Ma, E. Min, W. Jung, and G. Popescu, “Quantitative phase imaging for medical diagnosis,” J. Biophoton. 10, 177–205 (2017).
[Crossref]

M. Bedrossian, C. Lindensmith, and J. L. Nadeau, “Digital holographic microscopy, a method for detection of microorganisms in plume samples from Enceladus and other icy worlds,” Astrobiology 17, 913–925 (2017).
[Crossref]

D. Jin, Y. J. Sung, N. Lue, Y. H. Kim, P. T. C. So, and Z. Yaqoob, “Large population cell characterization using quantitative phase cytometer,” Cytometry A 91A, 450–459 (2017).
[Crossref]

X. Meng, H. C. Huang, K. D. Yan, X. L. Tian, W. Yu, H. Y. Cui, Y. Kong, L. Xue, C. Liu, and S. Y. Wang, “Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method,” Lab Chip 17, 104–109 (2017).
[Crossref]

C. Zheng, R. J. Zhou, C. F. Kuang, G. Y. Zhao, Z. M. Zhang, and X. Liu, “Diffraction phase microscopy realized with an automatic digital pinhole,” Opt. Commun. 404, 5–10 (2017).
[Crossref]

2016 (2)

P. Hosseini, R. J. Zhou, Y. H. Kim, C. Peres, A. Diaspro, C. F. Kuang, Z. Yaqoob, and P. T. C. So, “Pushing phase and amplitude sensitivity limits in interferometric microscopy,” Opt. Lett. 41, 1656–1659 (2016).
[Crossref]

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

2015 (1)

2014 (4)

2013 (6)

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

X. Ou, R. Horstmeyer, C. Yang, and G. Zheng, “Quantitative phase imaging via Fourier ptychographic microscopy,” Opt. Lett. 38, 4845–4848 (2013).
[Crossref]

G. Zheng, R. Horstmeyer, and C. Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nat. Photonics 7, 739–745 (2013).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

P. Girshovitz and N. T. Shaked, “Compact and portable low-coherence interferometer with off-axis geometry for quantitative phase microscopy and nanoscopy,” Opt. Express 21, 5701–5714 (2013).
[Crossref]

R. J. Zhou, C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Detecting 20 nm wide defects in large area nanopatterns using optical interferometric microscopy,” Nano Lett. 13, 3716–3721 (2013).
[Crossref]

2012 (3)

N. T. Shaked, “Quantitative phase microscopy of biological samples using a portable interferometer,” Opt. Lett. 37, 2016–2018 (2012).
[Crossref]

A. Greenbaum, W. Luo, T. W. Su, Z. Gorocs, L. Xue, S. O. Isikman, A. F. Coskun, O. Mudanyali, and A. Ozcan, “Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy,” Nat. Methods 9, 889–895 (2012).
[Crossref]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).
[Crossref]

2011 (2)

H. Pham, H. F. Ding, N. Sobh, M. Do, S. Patel, and G. Popescu, “Off-axis quantitative phase imaging processing using CUDA: toward real-time applications,” Biomed. Opt. Express 2, 1781–1793 (2011).
[Crossref]

W. H. Grover, A. K. Bryan, M. Diez-Silva, S. Suresh, J. M. Higgins, and S. R. Manalis, “Measuring single-cell density,” Proc. Natl. Acad. Sci. USA 108, 10992–10996 (2011).
[Crossref]

2010 (1)

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

2008 (2)

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cell Mol. Dis. 41, 10–16 (2008).
[Crossref]

Y. K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. S. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. USA 105, 13730–13735 (2008).
[Crossref]

2006 (3)

2005 (1)

1999 (1)

Almada, A. E.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Anselmo, A.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Arai, F.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Arbabi, A.

R. J. Zhou, C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Detecting 20 nm wide defects in large area nanopatterns using optical interferometric microscopy,” Nano Lett. 13, 3716–3721 (2013).
[Crossref]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).
[Crossref]

Badizadegan, K.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cell Mol. Dis. 41, 10–16 (2008).
[Crossref]

Bar-Nur, O.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Bedrossian, M.

M. Bedrossian, C. Lindensmith, and J. L. Nadeau, “Digital holographic microscopy, a method for detection of microorganisms in plume samples from Enceladus and other icy worlds,” Astrobiology 17, 913–925 (2017).
[Crossref]

Benjamin, B.

M. T. Postek, A. Vladar, B. Ming, and B. Benjamin, “Documentation for reference material (RM) 8820: a versatile, multipurpose dimensional metrology calibration standard for scanned particle beam, scanned probe and optical microscopy,” Special Publication (NIST SP) 1170 (2014).

Best, C. A.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

Bevilacqua, F.

Bhaduri, B.

Bian, Z. C.

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

Bryan, A. K.

W. H. Grover, A. K. Bryan, M. Diez-Silva, S. Suresh, J. M. Higgins, and S. R. Manalis, “Measuring single-cell density,” Proc. Natl. Acad. Sci. USA 108, 10992–10996 (2011).
[Crossref]

Cermak, N.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

Chang, G.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Charriere, F.

Chen, J.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

Cheung, P.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Cho, S.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Choi, W.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cell Mol. Dis. 41, 10–16 (2008).
[Crossref]

Choi, W. S.

Y. K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. S. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. USA 105, 13730–13735 (2008).
[Crossref]

Chung, P. L.

A. Greenbaum, Y. B. Zhang, A. Feizi, P. L. Chung, W. Luo, S. R. Kandukuri, and A. Ozcan, “Wide-field computational imaging of pathology slides using lens-free on-chip microscopy,” Sci. Transl. Med. 6, 267ra175 (2014).
[Crossref]

Coffey, A.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Colomb, T.

Coskun, A. F.

A. Greenbaum, W. Luo, T. W. Su, Z. Gorocs, L. Xue, S. O. Isikman, A. F. Coskun, O. Mudanyali, and A. Ozcan, “Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy,” Nat. Methods 9, 889–895 (2012).
[Crossref]

Cuche, E.

Cui, H. Y.

X. Meng, H. C. Huang, K. D. Yan, X. L. Tian, W. Yu, H. Y. Cui, Y. Kong, L. Xue, C. Liu, and S. Y. Wang, “Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method,” Lab Chip 17, 104–109 (2017).
[Crossref]

Dasari, R. R.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cell Mol. Dis. 41, 10–16 (2008).
[Crossref]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31, 775–777 (2006).
[Crossref]

Deming, J.

Depeursinge, C.

Di Stefano, B.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Diaspro, A.

Diez-Silva, M.

W. H. Grover, A. K. Bryan, M. Diez-Silva, S. Suresh, J. M. Higgins, and S. R. Manalis, “Measuring single-cell density,” Proc. Natl. Acad. Sci. USA 108, 10992–10996 (2011).
[Crossref]

Y. K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. S. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. USA 105, 13730–13735 (2008).
[Crossref]

Ding, H. F.

Do, M.

Edwards, C.

C. Edwards, R. J. Zhou, S. W. Hwang, S. J. McKeown, K. Y. Wang, B. Bhaduri, R. Ganti, P. J. Yunker, A. G. Yodh, J. A. Rogers, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: monitoring nanoscale dynamics in materials science [Invited],” Appl. Opt. 53, G33–G43 (2014).
[Crossref]

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photon. 6, 57–119 (2014).
[Crossref]

R. J. Zhou, C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Detecting 20 nm wide defects in large area nanopatterns using optical interferometric microscopy,” Nano Lett. 13, 3716–3721 (2013).
[Crossref]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).
[Crossref]

Emery, Y.

Feige, P.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Feijo Delgado, F.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

Feizi, A.

A. Greenbaum, Y. B. Zhang, A. Feizi, P. L. Chung, W. Luo, S. R. Kandukuri, and A. Ozcan, “Wide-field computational imaging of pathology slides using lens-free on-chip microscopy,” Sci. Transl. Med. 6, 267ra175 (2014).
[Crossref]

Feld, M. S.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

Y. K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. S. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. USA 105, 13730–13735 (2008).
[Crossref]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cell Mol. Dis. 41, 10–16 (2008).
[Crossref]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31, 775–777 (2006).
[Crossref]

Galvin, A.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Ganti, R.

Gerli, M. F. M.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Girshovitz, P.

Goda, K.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

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C. Edwards, R. J. Zhou, S. W. Hwang, S. J. McKeown, K. Y. Wang, B. Bhaduri, R. Ganti, P. J. Yunker, A. G. Yodh, J. A. Rogers, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: monitoring nanoscale dynamics in materials science [Invited],” Appl. Opt. 53, G33–G43 (2014).
[Crossref]

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photon. 6, 57–119 (2014).
[Crossref]

R. J. Zhou, C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Detecting 20 nm wide defects in large area nanopatterns using optical interferometric microscopy,” Nano Lett. 13, 3716–3721 (2013).
[Crossref]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).
[Crossref]

Gorocs, Z.

A. Greenbaum, W. Luo, T. W. Su, Z. Gorocs, L. Xue, S. O. Isikman, A. F. Coskun, O. Mudanyali, and A. Ozcan, “Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy,” Nat. Methods 9, 889–895 (2012).
[Crossref]

Greenbaum, A.

A. Greenbaum, Y. B. Zhang, A. Feizi, P. L. Chung, W. Luo, S. R. Kandukuri, and A. Ozcan, “Wide-field computational imaging of pathology slides using lens-free on-chip microscopy,” Sci. Transl. Med. 6, 267ra175 (2014).
[Crossref]

A. Greenbaum, W. Luo, T. W. Su, Z. Gorocs, L. Xue, S. O. Isikman, A. F. Coskun, O. Mudanyali, and A. Ozcan, “Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy,” Nat. Methods 9, 889–895 (2012).
[Crossref]

Grover, W. H.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

W. H. Grover, A. K. Bryan, M. Diez-Silva, S. Suresh, J. M. Higgins, and S. R. Manalis, “Measuring single-cell density,” Proc. Natl. Acad. Sci. USA 108, 10992–10996 (2011).
[Crossref]

Guo, C. F.

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

Hase, M.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Hashimoto, K.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

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K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

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F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

Henle, M. L.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

Heo, J.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Higgins, J. M.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

W. H. Grover, A. K. Bryan, M. Diez-Silva, S. Suresh, J. M. Higgins, and S. R. Manalis, “Measuring single-cell density,” Proc. Natl. Acad. Sci. USA 108, 10992–10996 (2011).
[Crossref]

Hiramatsu, K.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Hochedlinger, K.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
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G. Zheng, R. Horstmeyer, and C. Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nat. Photonics 7, 739–745 (2013).
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X. Ou, R. Horstmeyer, C. Yang, and G. Zheng, “Quantitative phase imaging via Fourier ptychographic microscopy,” Opt. Lett. 38, 4845–4848 (2013).
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Hoshino, Y.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Hosseini, P.

Huang, H. C.

X. Meng, H. C. Huang, K. D. Yan, X. L. Tian, W. Yu, H. Y. Cui, Y. Kong, L. Xue, C. Liu, and S. Y. Wang, “Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method,” Lab Chip 17, 104–109 (2017).
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Huang, Y. K.

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

Huebner, A. J.

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Hwang, S. W.

Ideguchi, T.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Ikeda, T.

Isikman, S. O.

A. Greenbaum, W. Luo, T. W. Su, Z. Gorocs, L. Xue, S. O. Isikman, A. F. Coskun, O. Mudanyali, and A. Ozcan, “Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy,” Nat. Methods 9, 889–895 (2012).
[Crossref]

Ito, T.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Ji, S. L.

C. Q. Yi, C. W. Li, S. L. Ji, and M. S. Yang, “Microfluidics technology for manipulation and analysis of biological cells,” Anal. Chim. Acta 560, 1–23 (2006).
[Crossref]

Jiang, S. W.

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

Jin, D.

D. Jin, Y. J. Sung, N. Lue, Y. H. Kim, P. T. C. So, and Z. Yaqoob, “Large population cell characterization using quantitative phase cytometer,” Cytometry A 91A, 450–459 (2017).
[Crossref]

Jo, Y.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Jung, J.

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
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Jung, W.

H. Majeed, S. Sridharan, M. Mir, L. H. Ma, E. Min, W. Jung, and G. Popescu, “Quantitative phase imaging for medical diagnosis,” J. Biophoton. 10, 177–205 (2017).
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Kandukuri, S. R.

A. Greenbaum, Y. B. Zhang, A. Feizi, P. L. Chung, W. Luo, S. R. Kandukuri, and A. Ozcan, “Wide-field computational imaging of pathology slides using lens-free on-chip microscopy,” Sci. Transl. Med. 6, 267ra175 (2014).
[Crossref]

Kasai, Y.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Kazyoba, P. E.

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

Kim, D. J.

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

Kim, K.

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Kim, Y. H.

D. Jin, Y. J. Sung, N. Lue, Y. H. Kim, P. T. C. So, and Z. Yaqoob, “Large population cell characterization using quantitative phase cytometer,” Cytometry A 91A, 450–459 (2017).
[Crossref]

P. Hosseini, R. J. Zhou, Y. H. Kim, C. Peres, A. Diaspro, C. F. Kuang, Z. Yaqoob, and P. T. C. So, “Pushing phase and amplitude sensitivity limits in interferometric microscopy,” Opt. Lett. 41, 1656–1659 (2016).
[Crossref]

Knudsen, S. M.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

Kong, Y.

X. Meng, H. C. Huang, K. D. Yan, X. L. Tian, W. Yu, H. Y. Cui, Y. Kong, L. Xue, C. Liu, and S. Y. Wang, “Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method,” Lab Chip 17, 104–109 (2017).
[Crossref]

Kuang, C. F.

C. Zheng, R. J. Zhou, C. F. Kuang, G. Y. Zhao, Z. M. Zhang, and X. Liu, “Diffraction phase microscopy realized with an automatic digital pinhole,” Opt. Commun. 404, 5–10 (2017).
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P. Hosseini, R. J. Zhou, Y. H. Kim, C. Peres, A. Diaspro, C. F. Kuang, Z. Yaqoob, and P. T. C. So, “Pushing phase and amplitude sensitivity limits in interferometric microscopy,” Opt. Lett. 41, 1656–1659 (2016).
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Kuhn, J.

Kuriabova, T.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

Lee, K.

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

K. Lee and Y. Park, “Quantitative phase imaging unit,” Opt. Lett. 39, 3630–3633 (2014).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Lee, S.

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Levine, A. J.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

Li, C. W.

C. Q. Yi, C. W. Li, S. L. Ji, and M. S. Yang, “Microfluidics technology for manipulation and analysis of biological cells,” Anal. Chim. Acta 560, 1–23 (2006).
[Crossref]

Li, Y.

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
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Lindensmith, C.

M. Bedrossian, C. Lindensmith, and J. L. Nadeau, “Digital holographic microscopy, a method for detection of microorganisms in plume samples from Enceladus and other icy worlds,” Astrobiology 17, 913–925 (2017).
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Zhao, G. Y.

C. Zheng, R. J. Zhou, C. F. Kuang, G. Y. Zhao, Z. M. Zhang, and X. Liu, “Diffraction phase microscopy realized with an automatic digital pinhole,” Opt. Commun. 404, 5–10 (2017).
[Crossref]

Zheng, C.

C. Zheng, R. J. Zhou, C. F. Kuang, G. Y. Zhao, Z. M. Zhang, and X. Liu, “Diffraction phase microscopy realized with an automatic digital pinhole,” Opt. Commun. 404, 5–10 (2017).
[Crossref]

Zheng, G.

G. Zheng, R. Horstmeyer, and C. Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nat. Photonics 7, 739–745 (2013).
[Crossref]

X. Ou, R. Horstmeyer, C. Yang, and G. Zheng, “Quantitative phase imaging via Fourier ptychographic microscopy,” Opt. Lett. 38, 4845–4848 (2013).
[Crossref]

Zheng, G. A.

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

Zhou, R. J.

Zhu, J. K.

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

Adv. Opt. Photon. (1)

Anal. Chim. Acta (1)

C. Q. Yi, C. W. Li, S. L. Ji, and M. S. Yang, “Microfluidics technology for manipulation and analysis of biological cells,” Anal. Chim. Acta 560, 1–23 (2006).
[Crossref]

Appl. Opt. (2)

Astrobiology (1)

M. Bedrossian, C. Lindensmith, and J. L. Nadeau, “Digital holographic microscopy, a method for detection of microorganisms in plume samples from Enceladus and other icy worlds,” Astrobiology 17, 913–925 (2017).
[Crossref]

Biomed. Opt. Express (1)

Blood Cell Mol. Dis. (1)

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cell Mol. Dis. 41, 10–16 (2008).
[Crossref]

Cytometry A (1)

D. Jin, Y. J. Sung, N. Lue, Y. H. Kim, P. T. C. So, and Z. Yaqoob, “Large population cell characterization using quantitative phase cytometer,” Cytometry A 91A, 450–459 (2017).
[Crossref]

J. Biophoton. (1)

H. Majeed, S. Sridharan, M. Mir, L. H. Ma, E. Min, W. Jung, and G. Popescu, “Quantitative phase imaging for medical diagnosis,” J. Biophoton. 10, 177–205 (2017).
[Crossref]

Lab Chip (2)

S. W. Jiang, J. K. Zhu, P. M. Song, C. F. Guo, Z. C. Bian, R. H. Wang, Y. K. Huang, S. Y. Wang, H. Zhang, and G. A. Zheng, “Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation,” Lab Chip 20, 1058–1065 (2020).
[Crossref]

X. Meng, H. C. Huang, K. D. Yan, X. L. Tian, W. Yu, H. Y. Cui, Y. Kong, L. Xue, C. Liu, and S. Y. Wang, “Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method,” Lab Chip 17, 104–109 (2017).
[Crossref]

Light Sci. Appl. (1)

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).
[Crossref]

Nano Lett. (1)

R. J. Zhou, C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Detecting 20 nm wide defects in large area nanopatterns using optical interferometric microscopy,” Nano Lett. 13, 3716–3721 (2013).
[Crossref]

Nat. Methods (1)

A. Greenbaum, W. Luo, T. W. Su, Z. Gorocs, L. Xue, S. O. Isikman, A. F. Coskun, O. Mudanyali, and A. Ozcan, “Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy,” Nat. Methods 9, 889–895 (2012).
[Crossref]

Nat. Photonics (2)

G. Zheng, R. Horstmeyer, and C. Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nat. Photonics 7, 739–745 (2013).
[Crossref]

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12, 578–589 (2018).
[Crossref]

Opt. Commun. (1)

C. Zheng, R. J. Zhou, C. F. Kuang, G. Y. Zhao, Z. M. Zhang, and X. Liu, “Diffraction phase microscopy realized with an automatic digital pinhole,” Opt. Commun. 404, 5–10 (2017).
[Crossref]

Opt. Express (2)

Opt. Lett. (7)

PLoS ONE (1)

F. Feijo Delgado, N. Cermak, V. C. Hecht, S. Son, Y. Li, S. M. Knudsen, S. Olcum, J. M. Higgins, J. Chen, W. H. Grover, and S. R. Manalis, “Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells,” PLoS ONE 8, e67590 (2013).
[Crossref]

Proc. Natl. Acad. Sci. USA (3)

Y. K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. S. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. USA 105, 13730–13735 (2008).
[Crossref]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. USA 107, 6731–6736 (2010).
[Crossref]

W. H. Grover, A. K. Bryan, M. Diez-Silva, S. Suresh, J. M. Higgins, and S. R. Manalis, “Measuring single-cell density,” Proc. Natl. Acad. Sci. USA 108, 10992–10996 (2011).
[Crossref]

Sci. Adv. (1)

K. Hiramatsu, T. Ideguchi, Y. Yonamine, S. Lee, Y. Z. Luo, K. Hashimoto, T. Ito, M. Hase, J. W. Park, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Hoshino, and K. Goda, “High-throughput label-free molecular fingerprinting flow cytometry,” Sci. Adv. 5, eaau0241 (2019).
[Crossref]

Sci. Rep. (1)

J. Jung, L. E. Matemba, K. Lee, P. E. Kazyoba, J. Yoon, J. J. Massaga, K. Kim, D. J. Kim, and Y. Park, “Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging,” Sci. Rep. 6, 31698 (2016).
[Crossref]

Sci. Transl. Med. (1)

A. Greenbaum, Y. B. Zhang, A. Feizi, P. L. Chung, W. Luo, S. R. Kandukuri, and A. Ozcan, “Wide-field computational imaging of pathology slides using lens-free on-chip microscopy,” Sci. Transl. Med. 6, 267ra175 (2014).
[Crossref]

Sensors (1)

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13, 4170–4191 (2013).
[Crossref]

Stem Cell Rep. (1)

O. Bar-Nur, M. F. M. Gerli, B. Di Stefano, A. E. Almada, A. Galvin, A. Coffey, A. J. Huebner, P. Feige, C. Verheul, P. Cheung, D. Payzin-Dogru, S. Paisant, A. Anselmo, R. I. Sadreyev, H. C. Ott, S. Tajbakhsh, M. A. Rudnicki, A. J. Wagers, and K. Hochedlinger, “Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors,” Stem Cell Rep. 10, 1505–1521 (2018).
[Crossref]

Other (2)

G. Popescu, Quantitative Phase Imaging of Cells and Tissues, 1st ed. (McGraw-Hill, 2011).

M. T. Postek, A. Vladar, B. Ming, and B. Benjamin, “Documentation for reference material (RM) 8820: a versatile, multipurpose dimensional metrology calibration standard for scanned particle beam, scanned probe and optical microscopy,” Special Publication (NIST SP) 1170 (2014).

Supplementary Material (1)

NameDescription
» Visualization 1       Visualization1

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Figures (8)

Fig. 1.
Fig. 1. (a) Schematic design of the portable QPM system. (b) Software GUI running on the laptop. (c) Actual portable QPM system. (d) Internal components of the portable QPM system.
Fig. 2.
Fig. 2. (a) Histogram of the OPD values for all the pixels of all the frames. (b) Temporal fluctuation of the frame-averaged OPD value. (c) Histogram of the OPD standard deviation values. (d) OPD map averaged over all the frames.
Fig. 3.
Fig. 3. (a) Typical SEM image for a portion of the NIST reference material (RM) 8820 sample showing the L500 nm S500 nm and L500 nm S1000 nm lines (figure adapted from Ref. [28]). (b) Phase map measured by the portable QPM system. Inset figure shows the line profile indicated by the white dotted line.
Fig. 4.
Fig. 4. (a) Design of the gold electrodes in transistor sample. (b) Height map of the sample from the portable QPM system; inset figure shows the line profile along the white dotted line in (b). (c) AFM image of the sample (Software: NanoScope Analysis 1.5); inset figure shows the line profile along the white dotted line in (c). (d) Height histogram of the Au structure area and the bottom area selected in (b). (e) Height histogram of the Au structure area and the bottom area selected in (c).
Fig. 5.
Fig. 5. (a) Height map of 5 μm beads. (b) Line profile along the yellow arrow direction for the bead indicated in (a).
Fig. 6.
Fig. 6. (a) Height map for a selected region in the NIST reference material (RM) 8820 sample. (b) Zoom-in height map for the selected area in (a). (c) SEM image of the selected area (figure adapted from Ref. [28]). (d) Histogram of the topography map in (b).
Fig. 7.
Fig. 7. (a) Raw interferogram of the RBCs with a zoom-in showing the fringe contrast and bending. (b) Retrieved height map of the RBCs in (a). (c) Snapshot of the membrane height fluctuation in Visualization 1 for the RBC selected in (b).
Fig. 8.
Fig. 8. (a) Actual microfluidic device and the geometry of the channels. (b) Representative phase image showing the imaging field of view of the microfluidic channel. (c) Histogram of the dry mass for all the cells captured in the microfluidic channel. (d) Phase maps of a few selected myoblasts captured in the microfluidic channel.

Equations (3)

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h(x,y)=φ(x,y)λ2πΔn,
h(x,y)=φ(x,y)λ4π,
M=λ/2παφ(x,y)dA,

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