Abstract

We present a compact multimodal fiber probe that enables the simultaneous recording of nonlinear imaging modalities like coherent anti-Stokes Raman scattering (CARS), second harmonic generation (SHG), and two-photon excited auto-fluorescence (TPEF) for biomedical applications. The probe is based on a gradient index lens design and a multi-core fiber supplying the excitation laser light. The multi-core fiber preserves the spatial relationship between the entrance and output; therefore, the laser scanning procedure can be shifted from the distal to the proximal end of the probe. No moving parts or electric power are required in situ. The generated sample signals can be collected in the backward (epi) direction and transferred to a detection setup with a multimode fiber integrated in the probe head. The first CARS/SHG/TPEF multimodal tissue images recorded with the introduced fiber probe will be presented.

© 2017 Optical Society of America

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References

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2016 (6)

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

G. Matz, B. Messerschmidt, and H. Gross, “Design and evaluation of new color-corrected rigid endomicroscopic high NA GRIN-objectives with a sub-micron resolution and large field of view,” Opt. Express 24, 10987–11001 (2016).
[Crossref]

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

2015 (4)

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

X. Chen, X. Xu, D. T. McCormick, K. Wong, and S. T. C. Wong, “Multimodal nonlinear endo-microscopy probe design for high resolution, label-free intraoperative imaging,” Biomed. Opt. Express 6, 2283–2293 (2015).
[Crossref]

W. Wang, J. Zhao, M. Short, and H. Zeng, “Real-time in vivo cancer diagnosis using Raman spectroscopy,” J. Biophoton. 8, 527–545 (2015).
[Crossref]

2014 (2)

P. Deladurantaye, A. Paquet, C. Paré, H. Zheng, M. Doucet, D. Gay, M. Poirier, J.-F. Cormier, O. Mermut, B. C. Wilson, and E. J. Seibel, “Advances in engineering of high contrast CARS imaging endoscopes,” Opt. Express 22, 25053–25064 (2014).
[Crossref]

A. Shinde and M. V. Matham, “Pixelate removal in an image fiber probe endoscope incorporating comb structure removal methods,” J. Med. Imag. Health Inform. 4, 203–211 (2014).
[Crossref]

2013 (7)

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

B. Smith, M. Naji, S. Murugkar, E. Alarcon, C. Brideau, P. Stys, and H. Anis, “Portable, miniaturized, fibre delivered, multimodal CARS exoscope,” Opt. Express 21, 17161–17175 (2013).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

T. Meyer, M. Schmitt, B. Dietzek, and J. Popp, “Accumulating advantages, reducing limitations: multimodal nonlinear imaging in biomedical sciences—the synergy of multiple contrast mechanisms,” J. Biophoton. 6, 887–904 (2013).
[Crossref]

2012 (2)

C. Krafft, B. Dietzek, M. Schmitt, and J. Popp, “Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications,” J. Biomed. Opt. 17, 040801 (2012).
[Crossref]

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40, 277–291 (2012).
[Crossref]

2011 (2)

B. G. Saar, R. S. Johnston, C. W. Freudiger, X. S. Xie, and E. J. Seibel, “Coherent Raman scanning fiber endoscopy,” Opt. Lett. 36, 2396–2398 (2011).
[Crossref]

J. C. O. Richter, N. Haj-Hosseini, S. Andersson-Engel, and K. Wårdell, “Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors,” Lasers Surg. Med. 43, 8–14 (2011).
[Crossref]

2010 (3)

2009 (1)

W. Wang, K. Zhang, Q. Ren, and J. U. Kang, “Comparison of different focusing systems for common-path optical coherence tomography with fiber-optic bundle as endoscopic probe,” Opt. Eng. 48, 103001 (2009).
[Crossref]

2007 (1)

L. Fu and M. Gu, “Fibre-optic nonlinear optical microscopy and endoscopy,” J. Microsc. 226, 195–206 (2007).
[Crossref]

2006 (1)

Akimov, D.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

Alarcon, E.

Andersson-Engel, S.

J. C. O. Richter, N. Haj-Hosseini, S. Andersson-Engel, and K. Wårdell, “Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors,” Lasers Surg. Med. 43, 8–14 (2011).
[Crossref]

Anis, H.

Atreya, R.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

Balu, M.

Baria, E.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

Baumgartl, M.

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Bec, J.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Bocklitz, T.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Bräuer, R.

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

Brehm, B. R.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Brideau, C.

Brown, E. B.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40, 277–291 (2012).
[Crossref]

Burke, R. M.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40, 277–291 (2012).
[Crossref]

Chemnitz, M.

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Chen, X.

Chen, Z.

Chernavskaia, O.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

Cicchi, R.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

Cormier, J.-F.

Deladurantaye, P.

Dietzek, B.

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Schmitt, B. Dietzek, and J. Popp, “Accumulating advantages, reducing limitations: multimodal nonlinear imaging in biomedical sciences—the synergy of multiple contrast mechanisms,” J. Biophoton. 6, 887–904 (2013).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

C. Krafft, B. Dietzek, M. Schmitt, and J. Popp, “Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications,” J. Biomed. Opt. 17, 040801 (2012).
[Crossref]

Dirsch, O.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

Dochow, S.

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

Doucet, M.

Eggeling, F. V.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

Ernst, G.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

Evans, C. L.

Fatakdawala, H.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Freudiger, C. W.

Friedrich, O.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

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L. Fu and M. Gu, “Fibre-optic nonlinear optical microscopy and endoscopy,” J. Microsc. 226, 195–206 (2007).
[Crossref]

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R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Ganikhanov, F.

Gay, D.

Gottschall, T.

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Greten, F. R.

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

Gross, H.

Gu, M.

L. Fu and M. Gu, “Fibre-optic nonlinear optical microscopy and endoscopy,” J. Microsc. 226, 195–206 (2007).
[Crossref]

Guntinas-Lichius, O.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
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J. C. O. Richter, N. Haj-Hosseini, S. Andersson-Engel, and K. Wårdell, “Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors,” Lasers Surg. Med. 43, 8–14 (2011).
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Hartl, B.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Heuke, S.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

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Jun, C. S.

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J.-H. Han, J. Lee, and J. U. Kang, “Pixelation effect removal from fiber bundle probe based optical coherence tomography imaging,” Opt. Express 18, 7427–7439 (2010).
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R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Kluschke, F.

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

Koch, E.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Krafft, C.

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

C. Krafft, B. Dietzek, M. Schmitt, and J. Popp, “Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications,” J. Biomed. Opt. 17, 040801 (2012).
[Crossref]

Lademann, J.

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

Lange, M.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

Latka, I.

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

Lattermann, A.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

Lee, E. S.

Lee, J.

Lee, J. Y.

Légaré, F.

Legesse, F. B.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

Leipnitz, E.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Limpert, J.

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Liu, G.

Lukic, A.

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

Ma, D.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Marcu, L.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Marple, E.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
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Matham, M. V.

A. Shinde and M. V. Matham, “Pixelate removal in an image fiber probe endoscope incorporating comb structure removal methods,” J. Med. Imag. Health Inform. 4, 203–211 (2014).
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Matthäaus, C.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

Matthäus, C.

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Matz, G.

McCormick, D. T.

Meinhardt, M.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Mermut, O.

Messerschmidt, B.

Meyer, T.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Meyer, M. Schmitt, B. Dietzek, and J. Popp, “Accumulating advantages, reducing limitations: multimodal nonlinear imaging in biomedical sciences—the synergy of multiple contrast mechanisms,” J. Biophoton. 6, 887–904 (2013).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Murugkar, S.

Naji, M.

Neurath, M.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

Paquet, A.

Paré, C.

Park, J. H.

Pascher, T.

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Pavone, F. S.

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

Perry, S. W.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40, 277–291 (2012).
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Petersen, I.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

Poirier, M.

Popp, J.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Schmitt, B. Dietzek, and J. Popp, “Accumulating advantages, reducing limitations: multimodal nonlinear imaging in biomedical sciences—the synergy of multiple contrast mechanisms,” J. Biophoton. 6, 887–904 (2013).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

C. Krafft, B. Dietzek, M. Schmitt, and J. Popp, “Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications,” J. Biomed. Opt. 17, 040801 (2012).
[Crossref]

Potma, E. O.

Ren, Q.

W. Wang, K. Zhang, Q. Ren, and J. U. Kang, “Comparison of different focusing systems for common-path optical coherence tomography with fiber-optic bundle as endoscopic probe,” Opt. Eng. 48, 103001 (2009).
[Crossref]

Richter, J. C. O.

J. C. O. Richter, N. Haj-Hosseini, S. Andersson-Engel, and K. Wårdell, “Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors,” Lasers Surg. Med. 43, 8–14 (2011).
[Crossref]

Roewert-Huber, H. J.

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

Romeike, B. F.

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Romeike, B. F. M.

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Saar, B. G.

Salah, F. S.

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

Schackert, G.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Schmidt, C.

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

Schmitt, M.

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Schmitt, B. Dietzek, and J. Popp, “Accumulating advantages, reducing limitations: multimodal nonlinear imaging in biomedical sciences—the synergy of multiple contrast mechanisms,” J. Biophoton. 6, 887–904 (2013).
[Crossref]

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

C. Krafft, B. Dietzek, M. Schmitt, and J. Popp, “Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications,” J. Biomed. Opt. 17, 040801 (2012).
[Crossref]

Schürmann, S.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

Schwuchow, A.

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

Seibel, E. J.

Shinde, A.

A. Shinde and M. V. Matham, “Pixelate removal in an image fiber probe endoscope incorporating comb structure removal methods,” J. Med. Imag. Health Inform. 4, 203–211 (2014).
[Crossref]

Short, M.

W. Wang, J. Zhao, M. Short, and H. Zeng, “Real-time in vivo cancer diagnosis using Raman spectroscopy,” J. Biophoton. 8, 527–545 (2015).
[Crossref]

Smith, B.

Stallmach, A.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

Steiner, G.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Stys, P.

Temme, A.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Tromberg, B. J.

Tünnermann, A.

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Uckermann, O.

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

Urmey, K.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Vieth, M.

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

Vogler, N.

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

von Eggeling, F.

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

Wachsmann-Hogiu, S.

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Waldner, M.

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

Wang, W.

W. Wang, J. Zhao, M. Short, and H. Zeng, “Real-time in vivo cancer diagnosis using Raman spectroscopy,” J. Biophoton. 8, 527–545 (2015).
[Crossref]

W. Wang, K. Zhang, Q. Ren, and J. U. Kang, “Comparison of different focusing systems for common-path optical coherence tomography with fiber-optic bundle as endoscopic probe,” Opt. Eng. 48, 103001 (2009).
[Crossref]

Wårdell, K.

J. C. O. Richter, N. Haj-Hosseini, S. Andersson-Engel, and K. Wårdell, “Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors,” Lasers Surg. Med. 43, 8–14 (2011).
[Crossref]

Wilson, B. C.

Wong, K.

Wong, S. T. C.

Wuttig, A.

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Xie, X. S.

Xu, X.

Yeom, D.-I.

Zeng, H.

W. Wang, J. Zhao, M. Short, and H. Zeng, “Real-time in vivo cancer diagnosis using Raman spectroscopy,” J. Biophoton. 8, 527–545 (2015).
[Crossref]

Zhang, K.

W. Wang, K. Zhang, Q. Ren, and J. U. Kang, “Comparison of different focusing systems for common-path optical coherence tomography with fiber-optic bundle as endoscopic probe,” Opt. Eng. 48, 103001 (2009).
[Crossref]

Zhao, J.

W. Wang, J. Zhao, M. Short, and H. Zeng, “Real-time in vivo cancer diagnosis using Raman spectroscopy,” J. Biophoton. 8, 527–545 (2015).
[Crossref]

Zheng, H.

Anal. Bioanal. Chem. (1)

S. Dochow, D. Ma, I. Latka, T. Bocklitz, B. Hartl, J. Bec, H. Fatakdawala, E. Marple, K. Urmey, S. Wachsmann-Hogiu, M. Schmitt, L. Marcu, and J. Popp, “Combined fiber probe for fluorescence lifetime and Raman spectroscopy,” Anal. Bioanal. Chem. 407, 8291–8301 (2015).
[Crossref]

Anal. Chem. (1)

T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B. F. M. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, and J. Popp, “Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics,” Anal. Chem. 85, 6703–6715 (2013).
[Crossref]

Analyst (1)

T. Meyer, M. Baumgartl, T. Gottschall, T. Pascher, A. Wuttig, C. Matthäus, B. F. Romeike, B. R. Brehm, J. Limpert, A. Tünnermann, O. Guntinas-Lichius, B. Dietzek, M. Schmitt, and J. Popp, “A compact microscope setup for multimodal nonlinear imaging in clinics and its application to disease diagnostics,” Analyst 138, 4048–4057 (2013).
[Crossref]

Ann. Biomed. Eng. (1)

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40, 277–291 (2012).
[Crossref]

Appl. Opt. (1)

Biomed. Opt. Express (1)

BMC Cancer (1)

T. Bocklitz, F. S. Salah, N. Vogler, S. Heuke, O. Chernavskaia, C. Schmidt, M. Waldner, F. R. Greten, R. Bräuer, M. Schmitt, A. Stallmach, I. Petersen, and J. Popp, “Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool,” BMC Cancer 16, 534 (2016).
[Crossref]

Br. J. Dermatol. (1)

S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H. J. Roewert-Huber, J. Lademann, B. Dietzek, and J. Popp, “Multimodal mapping of human skin,” Br. J. Dermatol. 169, 794–803 (2013).
[Crossref]

Head Neck (2)

T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, and J. Popp, “Multimodal nonlinear microscopic investigations on head and neck squamous cell carcinoma: toward intraoperative imaging,” Head Neck 35, E280–E287 (2013).
[Crossref]

S. Heuke, O. Chernavskaia, T. Bocklitz, F. B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. V. Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, and J. Popp, “Multimodal nonlinear microscopy of head and neck carcinoma—toward surgery assisting frozen section analysis,” Head Neck 38, 1545–1552 (2016).
[Crossref]

J. Biomed. Opt. (1)

C. Krafft, B. Dietzek, M. Schmitt, and J. Popp, “Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications,” J. Biomed. Opt. 17, 040801 (2012).
[Crossref]

J. Biophoton. (5)

W. Wang, J. Zhao, M. Short, and H. Zeng, “Real-time in vivo cancer diagnosis using Raman spectroscopy,” J. Biophoton. 8, 527–545 (2015).
[Crossref]

R. Galli, O. Uckermann, A. Temme, E. Leipnitz, M. Meinhardt, E. Koch, G. Schackert, G. Steiner, and M. Kirsch, “Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples,” J. Biophoton. 10, 404–414 (2016).
[Crossref]

T. Meyer, M. Schmitt, B. Dietzek, and J. Popp, “Accumulating advantages, reducing limitations: multimodal nonlinear imaging in biomedical sciences—the synergy of multiple contrast mechanisms,” J. Biophoton. 6, 887–904 (2013).
[Crossref]

R. Cicchi, E. Baria, C. Matthäaus, M. Lange, A. Lattermann, B. R. Brehm, J. Popp, and F. S. Pavone, “Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy,” J. Biophoton. 8, 347–356 (2015).
[Crossref]

A. Lukić, S. Dochow, O. Chernavskaia, I. Latka, C. Matthäus, A. Schwuchow, M. Schmitt, and J. Popp, “Fiber probe for nonlinear imaging applications,” J. Biophoton. 9, 138–143 (2016).
[Crossref]

J. Med. Imag. Health Inform. (1)

A. Shinde and M. V. Matham, “Pixelate removal in an image fiber probe endoscope incorporating comb structure removal methods,” J. Med. Imag. Health Inform. 4, 203–211 (2014).
[Crossref]

J. Microsc. (1)

L. Fu and M. Gu, “Fibre-optic nonlinear optical microscopy and endoscopy,” J. Microsc. 226, 195–206 (2007).
[Crossref]

Laser Photon. Rev. (1)

I. Latka, S. Dochow, C. Krafft, B. Dietzek, and J. Popp, “Fiber optic probes for linear and nonlinear Raman applications—current trends and future development,” Laser Photon. Rev. 7, 698–731 (2013).
[Crossref]

Lasers Surg. Med. (1)

J. C. O. Richter, N. Haj-Hosseini, S. Andersson-Engel, and K. Wårdell, “Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors,” Lasers Surg. Med. 43, 8–14 (2011).
[Crossref]

Opt. Eng. (1)

W. Wang, K. Zhang, Q. Ren, and J. U. Kang, “Comparison of different focusing systems for common-path optical coherence tomography with fiber-optic bundle as endoscopic probe,” Opt. Eng. 48, 103001 (2009).
[Crossref]

Opt. Express (6)

Opt. Lett. (1)

Sci. Rep. (1)

O. Chernavskaia, S. Heuke, M. Vieth, O. Friedrich, S. Schürmann, R. Atreya, A. Stallmach, M. Neurath, M. Waldner, I. Petersen, M. Schmitt, T. Bocklitz, and J. Popp, “Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging,” Sci. Rep. 6, 29239 (2016).
[Crossref]

Other (1)

Fujikura Ltd., Standard specifications for imagefibers, (2013).

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Figures (7)

Fig. 1.
Fig. 1.

SEM image of the imaging fiber (a) and microscope image with hundredfold magnification (b). (Adapted from [22].)

Fig. 2.
Fig. 2.

Imaging fiber probe design. The light from the imaging fiber (black) is collimated by a GRIN lens (white), and passes through a longpass filter (green) and a diffractive optical element DOE (red) before it gets focused by a second GRIN lens. The sample signal is collimated by this same GRIN lens, gets deflected by the longpass filter and a prism mirror (blue), and is focused by a third GRIN lens into the collecting fiber (blue with grey coating).

Fig. 3.
Fig. 3.

FWHM spot size for the pump beam (blue) and Stokes beam (red) after propagating through a central core of the imaging fiber shown in Fig. 1. Collimation and focusing with the objectives (Olympus NIR 10× NA=0.3) results in a focal shift of the two laser pulses. The pump and Stokes foci are separated by 20 μm (a), while the GRIN probe provides very good focusing for both wavelengths (b).

Fig. 4.
Fig. 4.

Different GRIN lens configurations contribute to different images recorded with a CCD camera. When the two GRIN lenses are separated by the same distance as inside the probe, vignetting occurs [white arrows in (a, c)]. By putting the optics close together, the vignetting disappears (b, d). It makes no difference if the DOE is located at the right position (a, b) or the wrong position (c, d).

Fig. 5.
Fig. 5.

Theoretical transmission spectrum of the longpass filter used in the probe head (red) and measured normalized transmission spectrum of the collecting path within the imaging fiber probe (black).

Fig. 6.
Fig. 6.

Coupling of the excitation lasers into the imaging fiber with a laser scanning microscope (left) and signal collection with a multimode fiber and three simultaneous detection channels (right).

Fig. 7.
Fig. 7.

Multimodal image of human skin tissue with CARS (red), SHG (blue), and TPEF (green) recorded with an LSM (a). The same tissue region was imaged with the fiber probe depicted in Figs. 2 and 6, including three separate images from each single detector channel (b).