Abstract
Photoacoustic microscopy (PAM) is a unique tool for biomedical applications because it can visualize optical absorption contrast in vivo. Recently, non-contact PAM based on non-interferometric photoacoustic remote sensing (PARS), termed PARS microscopy, has shown promise for selected imaging applications. A variety of superluminescent diodes (SLDs) have been employed in the PARS microscopy system as the interrogation light source. Here, we investigate the use of a low-cost laser diode (LD) as the interrogation light source in PARS microscopy, termed PARS-LD. A side-by-side comparison of PARS-LD and a PARS microscopy system using an SLD was conducted that showed comparable performance in terms of resolution and signal-to-noise ratio. More importantly, for the first time to our knowledge, in vivo PAM imaging of mouse brain vessels was conducted in a non-contact manner, and the results show that PARS-LD provides great performance.
© 2021 Optica Publishing Group
Full Article | PDF ArticleMore Like This
Zohreh Hosseinaee, Layla Khalili, James A. Tummon Simmons, Kevan Bell, and Parsin Haji Reza
Opt. Lett. 45(22) 6254-6257 (2020)
Jiasheng Zhou, Jingying Zhou, Wei Wang, Siqi Liang, Lili Jing, Shou-Hang Bo, and Sung-Liang Chen
Opt. Lett. 46(22) 5767-5770 (2021)
Jiasheng Zhou, Wei Wang, Lili Jing, and Sung-Liang Chen
Opt. Lett. 46(5) 997-1000 (2021)