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Transient-mode photothermal optical coherence tomography

Mohammad Hossein Salimi, Martin Villiger, and Nima Tabatabaei

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Abstract

Photothermal optical coherence tomography (PT-OCT) is an emerging extension of OCT, which forms images based on both scattering and absorption of light. The speed of PT-OCT, however, has been limited by the necessity for lock-in detection with extensive temporal sampling of the sample’s PT response. Here, we demonstrate transient-mode PT-OCT (TM-PT-OCT), which increases the effective A-line rate by orders of magnitude from 10–100 Hz to 1.5–7.5 kHz, by interrogating the sample’s transient thermal response to a single diode laser pulse. Functional imaging of moving samples with TM-PT-OCT at video rate is also presented. This significant improvement in imaging speed is expected to open the door for downstream integration of PT-OCT in clinical systems for in vivo imaging.

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Supplementary Material (3)

NameDescription
Supplement 1       Supplemental document
Visualization 1       Conventional (CW) PT-OCT imaging of moving phantom; absorber and non-absorber regions cannot be differentiated due to domination of noise at high effective line rate.
Visualization 2       Transient-Mode PT-OCT imaging of moving phantom; absorber and non-absorber are reliably distinguished at high effective line rate due to enhancement of SNR in TM-PT-OCT.

Data Availability

Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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