Abstract

The terahertz (THz) band, which corresponds to intermolecular binding energy, is the key to achieving a nonlabeled biosensor. To realize high-sensitivity binding detection, we focused on surface plasmon resonance (SPR) in the THz range. Using THz-SPR enhanced a in topological insulator, we expect to observe the synergistic effects of two resonance phenomena, namely intermolecular vibrational resonance and SPR. In this Letter, we report the nonlabeled detection of biomolecular binding by the topological insulator THz-SPR. ${{\rm Bi}_2}{{\rm Se}_3}$ was processed in a microribbon array to enhance the SPR in the THz range. The avidin–biotin specific binding, which is similar to the antigen–antibody reaction mechanism and has powerful interactions, was observed owing to enhancement by ${{\rm Bi}_2}{{\rm Se}_3}$ THz-SPR. This work paves the way for a system to directly measure specific molecular bonds using topological insulators.

© 2021 Optical Society of America

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Supplementary Material (1)

NameDescription
Supplement 1       Fig. S1, The mechanism of the resonance frequency shift; Fig. S2, THz transmittances before and after experiments

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Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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