Abstract

We present theoretical and experimental demonstrations of a novel, to the best of our knowledge, diffuse optical imaging method that is based on the concept of dual slopes (DS) in frequency-domain near-infrared spectroscopy. We consider a special array of sources and detectors that collects intensity ($I$) and phase ($\phi$) data with multiple DS sets. We have recently shown that ${\rm DS}\phi$ reflectance data features a deeper sensitivity with respect to ${\rm DS}\!I$ reflectance data. Here, for the first time, we describe a DS imaging approach based on the Moore-Penrose inverse of the sensitivity matrix for multiple DS data sets. Using a circular 8–source/9-detector array that generates 16 DS data sets at source-detector distances in the range 20–40 mm, we show that ${\rm DS}\!I$ images are more sensitive to superficial (${\lt}{5}\;{\rm mm}$) perturbations, whereas ${\rm DS}\phi$ images are more sensitive to deeper (${\gt}{10}\;{\rm mm}$) perturbations in highly scattering media.

© 2020 Optical Society of America

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