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Optical features of human skin revealed by optoacoustic mesoscopy in the visible and short-wave infrared regions

Andrei Berezhnoi, Juan Aguirre, Benedikt Hindelang, Natalie Garzorz-Stark, Murad Omar, Ulf Darsow, Kilian Eyerich, and Vasilis Ntziachristos

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Abstract

Detailed assessment of skin conditions or the efficacy of skin treatments could greatly benefit from noninvasively assessing the distribution of cutaneous and subcutaneous structures and biomolecules. We considered ultrawideband raster scan optoacoustic mesoscopy with an extended wavelength range from visible to short-wave infrared and observed previously unseen high-resolution images of lipids colocalized with water, melanin, and hemoglobin distribution in human skin. Based on this contrast, the technique resolves subcutaneous fat, the pilosebaceous unit with complete hair strand and bulb, dermal microvasculature, and epidermal structures. We further visualize melanoidins that form via the Maillard reaction in the ultrathin stratum corneum layer, analyze their absorption spectrum, and separate them from the melanin layer. The suggested method may allow novel interrogation of skin conditions, possibly impacting diagnostics and medical and cosmetic treatments.

© 2019 Optical Society of America

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Supplementary Material (5)

NameDescription
Visualization 1       3D optoacoustic image of human skin using UWSB-RSOM. Distribution of hemoglobin (microvasculature) and melanin in skin at 515 nm.
Visualization 2       3D optoacoustic image of human skin using UWSB-RSOM. Distribution of hemoglobin (microvasculature) and melanin in skin at 532 nm.
Visualization 3       3D optoacoustic image of human skin using UWSB-RSOM. Melanin in epidermis and hair imaged at 650 nm.
Visualization 4       3D optoacoustic image of human skin using UWSB-RSOM. Distribution of lipids and water in skin at 1210 nm.
Visualization 5       3D optoacoustic image of human skin using UWSB-RSOM. Distribution of water in skin at 1450 nm.

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