Abstract

Photo-mediated ultrasound therapy (PUT) is a novel, noninvasive antimicrovascular approach that can treat neovascularization with high precision. We developed a photoacoustic (PA) sensing (PAS) system for PUT and achieved real-time PAS-guided PUT. Experiments performed on a chicken yolk sac membrane model demonstrated that PAS could monitor the treatment effect in a microvessel during PUT. Vessel shrinkage induced a decrease in the PA signal amplitude, while vessel rupture induced an abrupt increase in the PA signal amplitude. The integrated PUT and PAS system can significantly improve the safety and effectiveness of PUT, and may assist with clinical translation of this novel antimicrovascular technique.

© 2019 Optical Society of America

Full Article  |  PDF Article

Corrections

14 August 2019: A typographical correction was made to the figures.


More Like This
Real-time functional photoacoustic remote sensing microscopy

Kevan L. Bell, Parsin Haji Reza, and Roger J. Zemp
Opt. Lett. 44(14) 3466-3469 (2019)

Real-time ultrasound sensing with a mode-optimized photonic crystal slab

Eric Y. Zhu, Maria Charles-Herrera, Cory Rewcastle, Raanan Gad, Li Qian, and Ofer Levi
Opt. Lett. 46(14) 3372-3375 (2021)

Ultrasound-assisted photothermal therapy and real-time treatment monitoring

Haemin Kim, Gyuwon Jo, and Jin Ho Chang
Biomed. Opt. Express 9(9) 4472-4480 (2018)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription