Abstract

We present a time domain diffuse Raman spectrometer for depth probing of highly scattering media. The system is based on, to the best of our knowledge, a novel time-correlated single-photon counting (TCSPC) camera that simultaneously acquires both spectral and temporal information of Raman photons. A dedicated non-contact probe was built, and time domain Raman measurements were performed on a tissue mimicking bilayer phantom. The fluorescence contamination of the Raman signal was eliminated by early time gating (0–212 ps) the Raman photons. Depth sensitivity is achieved by time gating Raman photons at different delays with a gate width of 106 ps. Importantly, the time domain can provide time-dependent depth sensitivity leading to a high contrast between two layers of Raman signal. As a result, an enhancement factor of 2170 was found for our bilayer phantom which is much higher than the values obtained by spatial offset Raman spectroscopy (SORS), frequency offset Raman spectroscopy (FORS), or hybrid FORS-SORS on a similar phantom.

© 2018 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Frequency offset Raman spectroscopy (FORS) for depth probing of diffusive media

Sanathana Konugolu Venkata Sekar, Sara Mosca, Andrea Farina, Fabrizio Martelli, Paola Taroni, Gianluca Valentini, Rinaldo Cubeddu, and Antonio Pifferi
Opt. Express 25(5) 4585-4597 (2017)

Time-domain diffuse correlation spectroscopy

Jason Sutin, Bernhard Zimmerman, Danil Tyulmankov, Davide Tamborini, Kuan Cheng Wu, Juliette Selb, Angelo Gulinatti, Ivan Rech, Alberto Tosi, David A. Boas, and Maria Angela Franceschini
Optica 3(9) 1006-1013 (2016)

Depth sensitivity of frequency domain optical measurements in diffusive media

Tiziano Binzoni, Angelo Sassaroli, Alessandro Torricelli, Lorenzo Spinelli, Andrea Farina, Turgut Durduran, Stefano Cavalieri, Antonio Pifferi, and Fabrizio Martelli
Biomed. Opt. Express 8(6) 2990-3004 (2017)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (1)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription