Abstract

The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.

© 2018 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Portable optical fiber probe for in vivo brain temperature measurements

Stefan Musolino, Erik P. Schartner, Georgios Tsiminis, Abdallah Salem, Tanya M. Monro, and Mark R. Hutchinson
Biomed. Opt. Express 7(8) 3069-3077 (2016)

Imaging deep skeletal muscle structure using a high-sensitivity ultrathin side-viewing optical coherence tomography needle probe

Xiaojie Yang, Dirk Lorenser, Robert A. McLaughlin, Rodney W. Kirk, Matthew Edmond, M. Cather Simpson, Miranda D. Grounds, and David D. Sampson
Biomed. Opt. Express 5(1) 136-148 (2014)

Near-infrared probe-based confocal microendoscope for deep-tissue imaging

Jiafu Wang, Hua Li, Geng Tian, Yong Deng, Qian Liu, and Ling Fu
Biomed. Opt. Express 9(10) 5011-5025 (2018)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription