Abstract

We demonstrate a real-time surface plasmon resonance imaging (SPRi) system based on a wavelength-swept laser. Compared to conventional spectral-modulation SPRi using white light source and spectral filtering, the proposed system has a higher scan rate to detect rapid changes in refractive index and a higher output power for large-area illumination. This SPRi system achieves scan rates faster than 12 Hz, simultaneously obtaining SPR dip positions over full illumination fields of 12×12mm. Using the wavelength-swept laser, two-dimensional biomolecular array imaging can be acquired with a high dynamic detection range (7.67×103 refractive index unit (RIU)) as well as high sensitivity (6501 nm/RIU) and resolution (1.89×106RIU).

© 2018 Optical Society of America

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Supplementary Material (2)

NameDescription
Visualization 1       Real-time full-field image of different concentration NaCl droplet on gold-chip.
Visualization 2       Real-time full-field image of dip position shift by antibody-antigen binding.

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