Abstract

Wide-field (WF) imaging paired with reflectance confocal microscopy can noninvasively detect skin cancer with high accuracy. However, two separate devices are required to perform each imaging procedure. We describe a new concept that integrates the two into one device: a miniature WF color camera within the objective lens used for confocal microscopy, providing simultaneous sub-surface cellular imaging and WF surface morphologic imaging. The camera, inserted between a hyperhemisphere front lens and a back lens group of the objective, commands a field of view of 4.0 mm, with a resolution better than 30 μm, while confocal optical sectioning is preserved at sharper than 2.5 μm.

© 2017 Optical Society of America

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Supplementary Material (1)

NameDescription
» Visualization 1: AVI (6421 KB)      This video shows superficial granular and spinous layers, consisting of a pattern of dark nuclei within bright grainy-appearing cells, and, as is also seen in Fig. 8, the underlying deeper clusters of basal cells and nevocyte cells.

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