Abstract

This Letter presents a novel dual modality reflection mode optical coherence and photoacoustic microscopy (OC-PAM) system. The optical coherence microscopy modality features a broadband source to accomplish 5 μm axial resolution. The photoacoustic microscopy modality uses a rigid akinetic Fabry–Perot etalon encapsulated in an optically transparent medium, which forms a 2  mm×11  mm translucent imaging window, permitting reflection mode dual modality imaging. After characterization, the OC-PAM system was applied to image zebrafish larvae in vivo, demonstrating its capability in biomedical imaging with complementary optical scattering and absorption contrasts by revealing morphology in the fish larvae.

© 2017 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2016 (5)

2015 (6)

2014 (3)

H. Li, B. Dong, Z. Zhang, H. F. Zhang, and C. Sun, Sci. Rep. 4, 4496 (2014).
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W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

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2013 (4)

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

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[Crossref]

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[Crossref]

2012 (3)

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[Crossref]

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[Crossref]

2011 (1)

2010 (1)

2009 (2)

Bauer-Marschallinger, J.

T. Berer, E. Leiss-Holzinger, A. Hochreiner, J. Bauer-Marschallinger, and A. Buchsbaum, J. Biomed. Opt. 20, 046013 (2015).
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Bell, K. L.

P. H. HajiReza, K. L. Bell, W. Shi, and R. J. Zemp, Proc. SPIE 10064, 1006420 (2017).
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Berer, T.

T. Berer, E. Leiss-Holzinger, A. Hochreiner, J. Bauer-Marschallinger, and A. Buchsbaum, J. Biomed. Opt. 20, 046013 (2015).
[Crossref]

Bondu, M.

Brett, M.

Buchsbaum, A.

T. Berer, E. Leiss-Holzinger, A. Hochreiner, J. Bauer-Marschallinger, and A. Buchsbaum, J. Biomed. Opt. 20, 046013 (2015).
[Crossref]

Buma, T.

Y. Shu, X. Guo, M. Liu, and T. Buma, IEEE Int. Ultra. Sym. (2011), pp. 2349–2352.

Burke, J. M.

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Cai, X.

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

Chai, X.

Chen, Z.

Choi, S.-W.

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

Dai, C.

Dong, B.

B. Dong, C. Sun, and H. F. Zhang, IEEE Trans. Biomed. Eng. 64, 4 (2017).
[Crossref]

X. Shu, M. Bondu, B. Dong, A. Podoleanu, L. Leick, and H. F. Zhang, Opt. Lett. 41, 2743 (2016).
[Crossref]

H. Li, B. Dong, Z. Zhang, H. F. Zhang, and C. Sun, Sci. Rep. 4, 4496 (2014).
[Crossref]

Drexler, W.

S. Preisser, W. Rohringer, M. Liu, C. Kollmann, S. Zotter, B. Fischer, and W. Drexler, Biomed. Opt. Express 7, 4171 (2016).
[Crossref]

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, J. Biomed. Opt. 19, 071412 (2014).
[Crossref]

Fawzi, A.

Fawzi, A. A.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

Fischer, B.

Guo, X.

Y. Shu, X. Guo, M. Liu, and T. Buma, IEEE Int. Ultra. Sym. (2011), pp. 2349–2352.

Hajireza, P.

HajiReza, P. H.

P. H. HajiReza, K. L. Bell, W. Shi, and R. J. Zemp, Proc. SPIE 10064, 1006420 (2017).
[Crossref]

Han, S.

Hermann, B.

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

Hochreiner, A.

T. Berer, E. Leiss-Holzinger, A. Hochreiner, J. Bauer-Marschallinger, and A. Buchsbaum, J. Biomed. Opt. 20, 046013 (2015).
[Crossref]

Hu, J. M.

Huang, Z.

Jeon, M.

Jeon, M. Y.

Jiang, H.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, J. Biophoton. (2017).
[Crossref]

Jiang, M. S.

Jiang, X.

Jiao, S.

Jiao, S. L.

Jin, T.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, J. Biophoton. (2017).
[Crossref]

Kamali, T.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, J. Biomed. Opt. 19, 071412 (2014).
[Crossref]

Kim, C.

D. Lee, C. Lee, S. Kim, Q. Zhou, J. Kim, and C. Kim, Sci. Rep. 6, 35176 (2016).
[Crossref]

C. Lee, S. Han, S. Kim, M. Jeon, M. Y. Jeon, C. Kim, and J. Kim, Appl. Opt. 52, 1824 (2013).
[Crossref]

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

Kim, J.

D. Lee, C. Lee, S. Kim, Q. Zhou, J. Kim, and C. Kim, Sci. Rep. 6, 35176 (2016).
[Crossref]

C. Lee, S. Han, S. Kim, M. Jeon, M. Y. Jeon, C. Kim, and J. Kim, Appl. Opt. 52, 1824 (2013).
[Crossref]

Kim, S.

D. Lee, C. Lee, S. Kim, Q. Zhou, J. Kim, and C. Kim, Sci. Rep. 6, 35176 (2016).
[Crossref]

C. Lee, S. Han, S. Kim, M. Jeon, M. Y. Jeon, C. Kim, and J. Kim, Appl. Opt. 52, 1824 (2013).
[Crossref]

Kolios, M. C.

K. Sathiyamoorthy, E. M. Strohm, and M. C. Kolios, J. Biomed. Opt. 22, 046001 (2017).
[Crossref]

Kollmann, C.

Krause, K.

Ku, G.

Kuai, D.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, J. Biomed. Opt. 17, 061206 (2012).
[Crossref]

Kumar, A.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, J. Biomed. Opt. 19, 071412 (2014).
[Crossref]

Lee, C.

D. Lee, C. Lee, S. Kim, Q. Zhou, J. Kim, and C. Kim, Sci. Rep. 6, 35176 (2016).
[Crossref]

C. Lee, S. Han, S. Kim, M. Jeon, M. Y. Jeon, C. Kim, and J. Kim, Appl. Opt. 52, 1824 (2013).
[Crossref]

Lee, D.

D. Lee, C. Lee, S. Kim, Q. Zhou, J. Kim, and C. Kim, Sci. Rep. 6, 35176 (2016).
[Crossref]

Leick, L.

Leiss-Holzinger, E.

T. Berer, E. Leiss-Holzinger, A. Hochreiner, J. Bauer-Marschallinger, and A. Buchsbaum, J. Biomed. Opt. 20, 046013 (2015).
[Crossref]

Leitgeb, R. A.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, J. Biomed. Opt. 19, 071412 (2014).
[Crossref]

Li, C.

Li, H.

H. Li, B. Dong, Z. Zhang, H. F. Zhang, and C. Sun, Sci. Rep. 4, 4496 (2014).
[Crossref]

Li, L.

L. Li, C. Dai, Q. Li, Q. Zhao, X. Jiang, X. Chai, and C. Zhou, Opt. Lett. 40, 4448 (2015).
[Crossref]

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

V. Tsytsarev, B. Rao, K. I. Maslov, L. Li, and L. V. Wang, J. Neurosci. Methods 216, 142 (2013).
[Crossref]

L. Li, K. Maslov, G. Ku, and L. V. Wang, Opt. Express 17, 16450 (2009).
[Crossref]

Li, Q.

Li, W.

Li, Y.

Linsenmeier, R. A.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

Liu, M.

S. Preisser, W. Rohringer, M. Liu, C. Kollmann, S. Zotter, B. Fischer, and W. Drexler, Biomed. Opt. Express 7, 4171 (2016).
[Crossref]

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, J. Biomed. Opt. 19, 071412 (2014).
[Crossref]

Y. Shu, X. Guo, M. Liu, and T. Buma, IEEE Int. Ultra. Sym. (2011), pp. 2349–2352.

Liu, T.

Liu, W.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

Liu, X.

MacEwan, M. R.

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

Maslov, K.

Maslov, K. I.

V. Tsytsarev, B. Rao, K. I. Maslov, L. Li, and L. V. Wang, J. Neurosci. Methods 216, 142 (2013).
[Crossref]

Maurer, B.

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

Meyer, D.

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

Podoleanu, A.

Preisser, S.

Puliafito, C. A.

Qi, W.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, J. Biophoton. (2017).
[Crossref]

Rao, B.

V. Tsytsarev, B. Rao, K. I. Maslov, L. Li, and L. V. Wang, J. Neurosci. Methods 216, 142 (2013).
[Crossref]

Ren, Q.

Rohringer, W.

Rong, J.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, J. Biophoton. (2017).
[Crossref]

Sathiyamoorthy, K.

K. Sathiyamoorthy, E. M. Strohm, and M. C. Kolios, J. Biomed. Opt. 22, 046001 (2017).
[Crossref]

Schmitner, N.

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

Shang, S.

Sheibani, N.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

Shi, W.

P. H. HajiReza, K. L. Bell, W. Shi, and R. J. Zemp, Proc. SPIE 10064, 1006420 (2017).
[Crossref]

Shu, X.

Shu, Y.

Y. Shu, X. Guo, M. Liu, and T. Buma, IEEE Int. Ultra. Sym. (2011), pp. 2349–2352.

Shung, K. K.

Song, W.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, J. Biomed. Opt. 17, 061206 (2012).
[Crossref]

Sorge, J.

Strohm, E. M.

K. Sathiyamoorthy, E. M. Strohm, and M. C. Kolios, J. Biomed. Opt. 22, 046001 (2017).
[Crossref]

Sun, C.

B. Dong, C. Sun, and H. F. Zhang, IEEE Trans. Biomed. Eng. 64, 4 (2017).
[Crossref]

H. Li, B. Dong, Z. Zhang, H. F. Zhang, and C. Sun, Sci. Rep. 4, 4496 (2014).
[Crossref]

Tsytsarev, V.

V. Tsytsarev, B. Rao, K. I. Maslov, L. Li, and L. V. Wang, J. Neurosci. Methods 216, 142 (2013).
[Crossref]

Unterhuber, A.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, J. Biomed. Opt. 19, 071412 (2014).
[Crossref]

Wang, G.

Wang, J.

Wang, L. V.

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

V. Tsytsarev, B. Rao, K. I. Maslov, L. Li, and L. V. Wang, J. Neurosci. Methods 216, 142 (2013).
[Crossref]

L. Li, K. Maslov, G. Ku, and L. V. Wang, Opt. Express 17, 16450 (2009).
[Crossref]

Wang, Y.

Wei, Q.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, J. Biomed. Opt. 17, 061206 (2012).
[Crossref]

T. Liu, Q. Wei, J. Wang, S. Jiao, and H. F. Zhang, Biomed. Opt. Express 2, 1359 (2011).
[Crossref]

Wen, R.

Weninger, W. J.

B. Hermann, M. Liu, N. Schmitner, B. Maurer, D. Meyer, W. J. Weninger, and W. Drexler, Proc. SPIE 9323, 93232N (2015).
[Crossref]

Xi, L.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, J. Biophoton. (2017).
[Crossref]

Xia, Y.

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

Xie, Z.

Xing, D.

Xiong, J.

Yang, R.

Yang, S.

Yao, J.

X. Cai, Y. Zhang, L. Li, S.-W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang, Tissue Eng., Part C 19, 196 (2013).
[Crossref]

Ye, S.

Yi, J.

W. Song, Q. Wei, W. Liu, T. Liu, J. Yi, N. Sheibani, A. A. Fawzi, R. A. Linsenmeier, S. Jiao, and H. F. Zhang, Sci. Rep. 4, 6525 (2014).
[Crossref]

Zemp, R.

Zemp, R. J.

P. H. HajiReza, K. L. Bell, W. Shi, and R. J. Zemp, Proc. SPIE 10064, 1006420 (2017).
[Crossref]

Zhang, H. F.

B. Dong, C. Sun, and H. F. Zhang, IEEE Trans. Biomed. Eng. 64, 4 (2017).
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Figures (4)

Fig. 1.
Fig. 1. (a) Schematic of the reflection mode OC-PAM system. (b) Photo of the scanning unit (inset, photo of the akinetic sensor). S, sensor holder; H, holder for sample; M, motorized stage; D, dichroic mirror; P, collimator for PAM; O, collimator for OCM; F, framework for the scanning unit. (c) Drawing of the sensor (unit, mm).
Fig. 2.
Fig. 2. (a) Typical photoacoustic signal captured by the PAM sub-system. (b) Simulated frequency response and the Fourier transform of the signal given in (a). (c) Effective imaging area expressed in sensitivity variation. (d) Sensitivity roll-off of the akinetic sensor over depth.
Fig. 3.
Fig. 3. Images of a 120 h post-fertilization (hpf) zebrafish larva. (a) Maximum intensity projection (MIP) image of OCM. (b) MAP image of PAM. (c) Color blended OC-PAM image using (a) and (b). (d)–(f) MIP images of OCM integrating 60 μm depth range. Blue arrow, pigments; blue square, swim bladder; blue diamond, eye; green circle, vesicle with otoliths; green square, yolk sac.
Fig. 4.
Fig. 4. PAM comparison between 120 hpf larvae from differently pigmented zebrafish strains using fast scanning PAM. The color bar shows the SNR in decibels. Upper image, mitfa b 692 / b 692 , ednrba b 140 / b 140 (AB) zebrafish, PTU treated; middle image, wild type AB* zebrafish, PTU treated; lower image, Tg(Fli:GFP) zebrafish. Blue arrows, pigment; blue square, swim bladder; blue diamond, eye; blue star, heart; magenta star, dorsal aorta; tip of magenta triangle, axial vein; magenta arrows, intersegmental vessels; green square, yolk sac.

Tables (1)

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Table 1. Specifications of the OC-PAM System

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