Abstract

The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4mm×0.5mm at 1,024,000 lines/s with 2×14μm resolution (axial×transverse) at a sensitivity of 113 dB. Imaging using the proposed system is demonstrated on highly differentiated human bronchial epithelial cells to capture and spatially localize ciliary dynamics.

© 2016 Optical Society of America

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Supplementary Material (2)

NameDescription
» Visualization 1: AVI (1317 KB)      Movie of beating cilia.
» Visualization 2: AVI (1347 KB)      Movie of beating cilia.

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