Abstract

We describe a novel technique for determination of the refractive index of hard biological tissue as well as nonopaque technical samples based on optical coherence tomography (OCT). Our method relies on an inverse refractive-index correction (I-RIC), which matches a measured feature geometry distorted due to refractive-index boundaries to its real geometry. For known feature geometry, the refractive index can be determined with high precision from the best match between the distorted and corrected images. We provide experimental data for refractive-index measurements on a polymethylmethacrylate (PMMA) and on an ex vivo porcine cranial-bone, which are compared to reference measurements and previously published data. Our method is potentially capable of in vivo measurements on rigid biological tissue such as bone as, for example, is required to improve guidance in robot-aided surgical interventions and also for retrieving complex refractive-index profiles of compound materials.

© 2015 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Finite-element-based photoacoustic tomography: phantom and chicken bone experiments

Zhen Yuan, Hongzhi Zhao, Changfeng Wu, Qizhi Zhang, and Huabei Jiang
Appl. Opt. 45(13) 3177-3183 (2006)

Time-resolved diffuse optical spectroscopy of small tissue samples

Paola Taroni, Daniela Comelli, Andrea Farina, Antonio Pifferi, and Alwin Kienle
Opt. Express 15(6) 3301-3311 (2007)

Image-guided Raman spectroscopic recovery of canine cortical bone contrast in situ

Subhadra Srinivasan, Matthew Schulmerich, Jacqueline H. Cole, Kathryn A. Dooley, Jaclynn M. Kreider, Brian W. Pogue, Michael D. Morris, and Steven A. Goldstein
Opt. Express 16(16) 12190-12200 (2008)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (2)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription