Abstract

There is growing interest in new neuroimage techniques that permit not only high-resolution quantification of cerebral blood flow velocity (CBFv) in capillaries, but also a large field of view to map the CBFv network dynamics. Such image capabilities are of great importance for decoding the functional difference across multiple cortical layers under stimuli. To tackle the limitation of optical penetration depth, we present a new ultrahigh-resolution optical coherence Doppler tomography (μODT) system at 1310 nm and compare it with a prior 800 nm μODT system for mouse brain 3D CBFv imaging. We show that the new 1310 nm μODT allows for dramatically increased depth (4 times) of quantitative CBFv imaging to 1.4 mm, thus covering the full thickness of the mouse cortex (i.e., layers I-VI). Interestingly, we show that such a unique 3D CBFv imaging capability allows identification of microcirculatory redistribution across different cortical layers resulting from repeated cocaine exposures.

© 2015 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

Jiang You, Congwu Du, Nora D. Volkow, and Yingtian Pan
Biomed. Opt. Express 5(9) 3217-3230 (2014)

Holographic laser Doppler imaging of microvascular blood flow

C. Magnain, A. Castel, T. Boucneau, M. Simonutti, I. Ferezou, A. Rancillac, T. Vitalis, J. A. Sahel, M. Paques, and M. Atlan
J. Opt. Soc. Am. A 31(12) 2723-2735 (2014)

Quantification of cocaine-induced cortical blood flow changes using laser speckle contrast imaging and Doppler optical coherence tomography

Zhongchi Luo, Zhijia Yuan, Melissa Tully, Yingtian Pan, and Congwu Du
Appl. Opt. 48(10) D247-D255 (2009)

References

  • View by:
  • |
  • |
  • |

  1. J. DeFelipe, L. Alonso-Nanclares, and J. Arellano, J. Neurocytol. 31, 299 (2002).
    [Crossref]
  2. K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
    [Crossref]
  3. D. Kobat, M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, Opt. Express 17, 13354 (2009).
    [Crossref]
  4. J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
    [Crossref]
  5. R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, Opt. Express 15, 4083 (2007).
    [Crossref]
  6. V. J. Srinivasan and H. Radhakrishnan, NeuroImage 102, 393 (2014).
    [Crossref]
  7. H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
    [Crossref]
  8. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 114 (2000).
    [Crossref]
  9. J. You, C. Du, N. D. Volkow, and Y. Pan, Biomed. Opt. Express 5, 3217 (2014).
    [Crossref]
  10. M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
    [Crossref]
  11. A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
    [Crossref]
  12. Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
    [Crossref]
  13. P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
    [Crossref]

2015 (1)

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

2014 (3)

V. J. Srinivasan and H. Radhakrishnan, NeuroImage 102, 393 (2014).
[Crossref]

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

J. You, C. Du, N. D. Volkow, and Y. Pan, Biomed. Opt. Express 5, 3217 (2014).
[Crossref]

2013 (1)

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

2012 (2)

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

2011 (1)

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

2009 (1)

2007 (1)

2002 (1)

J. DeFelipe, L. Alonso-Nanclares, and J. Arellano, J. Neurocytol. 31, 299 (2002).
[Crossref]

2000 (1)

1992 (1)

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Alonso-Nanclares, L.

J. DeFelipe, L. Alonso-Nanclares, and J. Arellano, J. Neurocytol. 31, 299 (2002).
[Crossref]

Arellano, J.

J. DeFelipe, L. Alonso-Nanclares, and J. Arellano, J. Neurocytol. 31, 299 (2002).
[Crossref]

Belliveau, J. W.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Blinder, P.

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

Bukowska, D.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Chen, Z.

Chesler, D. A.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Cohen, M. S.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

de Boer, J. F.

DeFelipe, J.

J. DeFelipe, L. Alonso-Nanclares, and J. Arellano, J. Neurocytol. 31, 299 (2002).
[Crossref]

Drew, P. J.

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

Driscoll, J. D.

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

Du, C.

J. You, C. Du, N. D. Volkow, and Y. Pan, Biomed. Opt. Express 5, 3217 (2014).
[Crossref]

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Durst, M. E.

Goldberg, I. E.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Gorczynska, I.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Gruber, A.

Hanson, S. R.

Hoppel, B. E.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Huang, C. H.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Hurst, S.

Jacques, S. L.

Kaufhold, J. P.

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

Kennedy, D. N.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Kleinfeld, D.

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

Knutsen, P. M.

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

Kobat, D.

Kwong, K. K.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Li, L.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Ma, Z.

Maslov, K. I.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Nelson, J. S.

Nishimura, N.

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

D. Kobat, M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, Opt. Express 17, 13354 (2009).
[Crossref]

Pan, Y.

J. You, C. Du, N. D. Volkow, and Y. Pan, Biomed. Opt. Express 5, 3217 (2014).
[Crossref]

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Park, K.

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Poncelet, B. P.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Radhakrishnan, H.

V. J. Srinivasan and H. Radhakrishnan, NeuroImage 102, 393 (2014).
[Crossref]

Ren, H.

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Saxer, C.

Schaffer, C. B.

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

D. Kobat, M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, Opt. Express 17, 13354 (2009).
[Crossref]

Shih, A. Y.

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

Srinivasan, V. J.

V. J. Srinivasan and H. Radhakrishnan, NeuroImage 102, 393 (2014).
[Crossref]

Suhl, H.

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

Sylwestrzak, M.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Szkulmowski, M.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Szlag, D.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Targowski, P.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Tsai, P. S.

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

Turner, R.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Volkow, N. D.

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

J. You, C. Du, N. D. Volkow, and Y. Pan, Biomed. Opt. Express 5, 3217 (2014).
[Crossref]

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Wang, L.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Wang, L. V.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Wang, R. K.

Weisskoff, R. M.

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Wojtkowski, M.

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

Wong, A. W.

Wong, T. T.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Xiang, S.

Xu, C.

Yang, J. M.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Yao, J.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

You, J.

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

J. You, C. Du, N. D. Volkow, and Y. Pan, Biomed. Opt. Express 5, 3217 (2014).
[Crossref]

Yuan, Z.

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Zhao, Y.

Zou, J.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Biomed. Opt. Express (1)

J. Biomed Opt. (1)

M. Sylwestrzak, D. Szlag, M. Szkulmowski, I. Gorczynska, D. Bukowska, M. Wojtkowski, and P. Targowski, J. Biomed Opt. 17, 100502 (2012).
[Crossref]

J. Cereb. Blood Flow Metab. (1)

A. Y. Shih, J. D. Driscoll, P. J. Drew, N. Nishimura, C. B. Schaffer, and D. Kleinfeld, J. Cereb. Blood Flow Metab. 32, 1277 (2012).
[Crossref]

J. Neurocytol. (1)

J. DeFelipe, L. Alonso-Nanclares, and J. Arellano, J. Neurocytol. 31, 299 (2002).
[Crossref]

Mol. Psychiatry (1)

H. Ren, C. Du, Z. Yuan, K. Park, N. D. Volkow, and Y. Pan, Mol. Psychiatry 17, 1017 (2011).
[Crossref]

Nat. Methods (1)

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, Nat. Methods 12, 407 (2015).
[Crossref]

Nat. Neurosci. (1)

P. Blinder, P. S. Tsai, J. P. Kaufhold, P. M. Knutsen, H. Suhl, and D. Kleinfeld, Nat. Neurosci. 16, 889 (2013).
[Crossref]

NeuroImage (2)

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, NeuroImage 103, 492 (2014).
[Crossref]

V. J. Srinivasan and H. Radhakrishnan, NeuroImage 102, 393 (2014).
[Crossref]

Opt. Express (2)

Opt. Lett. (1)

Proc. Natl. Acad. Sci. USA (1)

K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, and R. Turner, Proc. Natl. Acad. Sci. USA 89, 5675 (1992).
[Crossref]

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1.
Fig. 1.

In vivo 3D CBFv networks on the mouse sensorimotor cortex ( 2.4 mm × 2.0 mm ) imaged by 800 nm μODT vs 1310 nm μODT. (a), (b) 3D rendering to illustrate dramatically enhanced image depth by 1310 nm μODT. ( a ) and ( b ) Corresponding MIP images. (c)–(f) En face CBFv images of sub-stack cortex at different depths from 0 to 1.4 mm. (g) Capillary CBFv at different depths. CTX, cortex; CC, corpus callosum. Low-dose intralipid ( 0.5 mg / kg / h ) was given to the animal intravenously as an optical contrast agent to enhance capillary flow sensitivity for panels (a) and (b).

Fig. 2.
Fig. 2.

3D cerebrovasculature of the mouse sensorimotor cortex ( 2.0 mm × 0.5 mm × 1.4 mm ) acquired by 1310 nm contrast-enhanced μODT. Right panel, statistical distribution of microvasculatural density (fill factor) as a function of depth below the cortical surface. Arrows, penetrating pial vessels.

Fig. 3.
Fig. 3.

In vivo CBFv images of left and right sensorimotor cortices of a mouse after repeated cocaine exposures ( 30 mg / kg , i.p.) acquired by 1310 nm μODT. (a), (b) upper cortices; (c), (d) deeper cortices; (e) statistic comparison of capillary CBFv between left and right cortices.

Metrics