Abstract

The feasibility of diagnostic imaging and tissue characterization based on a new contrast realized by dual-pulse photoacoustic measurement was studied. Unlike current photoacoustic methods which are mostly focused on the measurement of tissue optical absorption, this contrast revealed by a dual-pulse laser excitation process takes advantage of the temperature dependence of the Grüneisen parameter of tissue. The first laser pulse heats the sample and causes a temperature rise in the target tissue, which leads to a change of the Grüneisen parameter and the amplitude of the photoacoustic signal from the second laser pulse. This new contrast is then quantified by percentile change in the second pulse signal as a result of the first laser pulse. Since the temperature-dependent Grüneisen parameter is tissue specific and closely relevant to chemical and molecular properties of the sample, the dual-pulse photoacoustic measurement can differentiate various tissue types and conditions. The preliminary study on phantoms and a mouse model has suggested the capability of the proposed contrast in the characterization of fatty livers and the potential for future clinical diagnosis of liver conditions.

© 2015 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Dual-pulse nonlinear photoacoustic technique: a practical investigation

Chao Tian, Zhixing Xie, Mario L. Fabiilli, Shengchun Liu, Cheng Wang, Qian Cheng, and Xueding Wang
Biomed. Opt. Express 6(8) 2923-2933 (2015)

Interstitial photoacoustic spectral analysis: instrumentation and validation

Haonan Zhang, Wan-yu Chao, Qian Cheng, Shengsong Huang, Xueding Wang, Denglong Wu, and Guan Xu
Biomed. Opt. Express 8(3) 1689-1697 (2017)

Characterizing intestinal inflammation and fibrosis in Crohn’s disease by photoacoustic imaging: feasibility study

Hao Lei, Laura A. Johnson, Shengchun Liu, David S. Moons, Teng Ma, Qifa Zhou, Michael D. Rice, Jun Ni, Xueding Wang, Peter D. R. Higgins, and Guan Xu
Biomed. Opt. Express 7(7) 2837-2848 (2016)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (6)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription