Abstract

In this Letter, the impact of blood vessels on light distribution during photostimulation of cortical tissue in small rodents is investigated. Brain optical properties were extracted using a double-integrating sphere setup, and optical coherence tomography was used to image cortical vessels and capillaries to generate a three-dimensional angiogram of the cortex. By combining these two datasets, a complete volumetric structure of the cortical tissue was developed and linked to a Monte Carlo code which simulates light propagation in this inhomogeneous structure and illustrates the effect of blood vessels on the penetration depth and pattern preservation in optogenetic stimulation.

© 2015 Optical Society of America

Full Article  |  PDF Article
More Like This
Quantitative imaging of microvascular blood flow networks in deep cortical layers by 1310 nm μODT

Jiang You, Qiujia Zhang, Kicheon Park, Congwu Du, and Yingtian Pan
Opt. Lett. 40(18) 4293-4296 (2015)

OptogenSIM: a 3D Monte Carlo simulation platform for light delivery design in optogenetics

Yuming Liu, Steven L. Jacques, Mehdi Azimipour, Jeremy D. Rogers, Ramin Pashaie, and Kevin W. Eliceiri
Biomed. Opt. Express 6(12) 4859-4870 (2015)

Sensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures

Julien Pichette, Andréanne Goyette, Fabien Picot, Marie-Andrée Tremblay, Gilles Soulez, Brian C. Wilson, and Frédéric Leblond
Biomed. Opt. Express 6(11) 4238-4254 (2015)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics