Abstract

Photothermal therapy is performed by delivering laser radiation into the target lesion containing tissue chromophores so as to induce localized heating. For high treatment efficacy, the laser wavelength should be selected to maximize the absorption of incident laser radiation in the tissue chromophores. However, even with the optimal laser wavelength, both the absorption and the scattering of laser energy in tissue openly hamper treatment efficacy in deep-lying lesions. To overcome the limitation, we propose a dual thermal therapeutic method in which both laser and acoustic energies are transmitted to increase therapeutic depth while maintaining high target selectivity of photothermal therapy. Through skin-mimicking phantom experiments, it was verified that the two different energies are complementary in elevation of tissue temperature, and the treatment depth using laser radiation is increased along with acoustic energy.

© 2014 Optical Society of America

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  1. S. L. Jacques, Phys. Med. Biol. 58, R37 (2013).
    [CrossRef]
  2. P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).
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    [CrossRef]
  4. C. Raulin and S. Karsai, eds., Laser and IPL Technology in Dermatology and Aesthetic Medicine (Springer-Verlag, 2011).
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    [CrossRef]
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    [CrossRef]
  7. J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
    [CrossRef]
  8. F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
    [CrossRef]
  9. J. R. McLaughlan, R. A. Roy, H. Ju, and T. W. Murray, Opt. Lett. 35, 2127 (2010).
    [CrossRef]
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    [CrossRef]
  11. J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
    [CrossRef]
  12. J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
    [CrossRef]

2013 (2)

S. L. Jacques, Phys. Med. Biol. 58, R37 (2013).
[CrossRef]

J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
[CrossRef]

2011 (1)

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

2010 (2)

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

J. R. McLaughlan, R. A. Roy, H. Ju, and T. W. Murray, Opt. Lett. 35, 2127 (2010).
[CrossRef]

2008 (2)

H. Morris, I. Rivens, A. Shaw, and G. ter Haar, Phys. Med. Biol. 53, 4759 (2008).
[CrossRef]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

2003 (2)

J. E. Kennedy, G. R. Ter Haar, and D. Cranston, Br. J. Radiol. 76, 590 (2003).
[CrossRef]

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

1998 (1)

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Aglyamov, S.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Alam, M.

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

Chang, J. H.

J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
[CrossRef]

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

Comelli, D.

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

Cranston, D.

J. E. Kennedy, G. R. Ter Haar, and D. Cranston, Br. J. Radiol. 76, 590 (2003).
[CrossRef]

Cubeddu, R.

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

Denham, D. B.

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Duvic, M.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

Emelianov, S. Y.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Garcia-Uribe, A.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

Gonzalez-Cirre, X.

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Jacques, S. L.

S. L. Jacques, Phys. Med. Biol. 58, R37 (2013).
[CrossRef]

Johnston, K.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Ju, H.

Kang, J.

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

Kennedy, J. E.

J. E. Kennedy, G. R. Ter Haar, and D. Cranston, Br. J. Radiol. 76, 590 (2003).
[CrossRef]

Kim, E.-K.

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

Kim, G. R.

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

Larson, T.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Ma, L.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Manns, F.

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Martin, N.

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

McLaughlan, J. R.

Milne, P. J.

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Milner, T.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Morris, H.

H. Morris, I. Rivens, A. Shaw, and G. ter Haar, Phys. Med. Biol. 53, 4759 (2008).
[CrossRef]

Murray, T. W.

Parel, J.-M.

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Park, S.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Pifferi, A.

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

Prieto, V.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

Rivens, I.

H. Morris, I. Rivens, A. Shaw, and G. ter Haar, Phys. Med. Biol. 53, 4759 (2008).
[CrossRef]

Robinson, D. S.

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Roy, R. A.

Shah, J.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Shaw, A.

H. Morris, I. Rivens, A. Shaw, and G. ter Haar, Phys. Med. Biol. 53, 4759 (2008).
[CrossRef]

Smith, E. B.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

Sokolov, K.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Song, J. H.

J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
[CrossRef]

Song, T.-K.

J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
[CrossRef]

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

Taroni, P.

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

ter Haar, G.

H. Morris, I. Rivens, A. Shaw, and G. ter Haar, Phys. Med. Biol. 53, 4759 (2008).
[CrossRef]

Ter Haar, G. R.

J. E. Kennedy, G. R. Ter Haar, and D. Cranston, Br. J. Radiol. 76, 590 (2003).
[CrossRef]

Torricelli, A.

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

Wang, L. V.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

West, D. P.

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

White, L. E.

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

Witherspoon, J.

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

Yoo, S.

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

Yoo, Y.

J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
[CrossRef]

Yoon, C.

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

Zou, J.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

Br. J. Radiol. (1)

J. E. Kennedy, G. R. Ter Haar, and D. Cranston, Br. J. Radiol. 76, 590 (2003).
[CrossRef]

J. Am. Acad. Dematol. (1)

M. Alam, L. E. White, N. Martin, J. Witherspoon, S. Yoo, and D. P. West, J. Am. Acad. Dematol. 62, 262 (2010).
[CrossRef]

J. Biomed. Opt. (2)

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, J. Biomed. Opt. 16, 020501 (2011).
[CrossRef]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, J. Biomed. Opt. 13, 034024 (2008).
[CrossRef]

Lasers Surg. Med. (1)

F. Manns, P. J. Milne, X. Gonzalez-Cirre, D. B. Denham, J.-M. Parel, and D. S. Robinson, Lasers Surg. Med. 23, 94 (1998).
[CrossRef]

Opt. Lett. (1)

Photochem. Photobiol. Sci. (1)

P. Taroni, A. Pifferi, A. Torricelli, D. Comelli, and R. Cubeddu, Photochem. Photobiol. Sci. 2, 124 (2003).

Phys. Med. Biol. (3)

S. L. Jacques, Phys. Med. Biol. 58, R37 (2013).
[CrossRef]

H. Morris, I. Rivens, A. Shaw, and G. ter Haar, Phys. Med. Biol. 53, 4759 (2008).
[CrossRef]

J. H. Song, Y. Yoo, T.-K. Song, and J. H. Chang, Phys. Med. Biol. 58, 5333 (2013).
[CrossRef]

Other (2)

J. Kang, E.-K. Kim, G. R. Kim, C. Yoon, T.-K. Song, and J. H. Chang, J. Biophoton., doi: 10.1002/jbio.201300100 (2013).
[CrossRef]

C. Raulin and S. Karsai, eds., Laser and IPL Technology in Dermatology and Aesthetic Medicine (Springer-Verlag, 2011).

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Figures (4)

Fig. 1.
Fig. 1.

(a) Photograph of a custom-made skin-mimicking phantom consisting of a front section of 4 mm thickness and a light-absorbing section of 16 mm thickness. (b) Experiment arrangement for measuring temperature change and lesion formation depth.

Fig. 2.
Fig. 2.

Temperature change as (a) a function of the spatial-peak temporal-average intensity (ISPTA) of the HIFU transducer and as (b) a function of laser fluence.

Fig. 3.
Fig. 3.

Depth of lesion formation as a function of laser fluence. The solid line indicates the lesion formation depth when only laser radiation was delivered into the target. The dotted line represents the case of transmitting both laser and acoustic energies at the same time.

Fig. 4.
Fig. 4.

Ultrasound images of lesion formation when (a) only laser radiation of 58.5mJ/cm2 was delivered and (b) laser radiation of 47.5mJ/cm2 and HIFU of 267.8W/cm2 were simultaneously transmitted. (c) and (d) were obtained when the laser fluence was, respectively, 58.5mJ/cm2 and 78.5mJ/cm2, and the HIFU was 267.8W/cm2. The white arrowhead indicates the boundary between the water and the surface of the skin-mimicking phantom, and the white arrow indicates the boundary between the front section and the light absorbing section. The dynamic range of the images was 40 dB.

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