Abstract

We present a novel design for an endoscopic imaging catheter utilizing diffractive optics for ultrahigh-resolution optical coherence tomography (OCT) imaging at 800 nm. A diffractive microlens was developed to alleviate severe chromatic aberration when a broadband light source was employed at the 800 nm wavelength range. Combined with a home-built fiber rotary joint and a broadband Ti:sapphire laser, the imaging catheter achieved a lateral resolution of 6.2 μm and an axial resolution of 3.0 μm in air. The performance of the catheter was demonstrated by three-dimensional full-circumferential endoscopic OCT imaging of guinea pig esophagus in vivo.

© 2014 Optical Society of America

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2011 (1)

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

2010 (1)

2009 (2)

2008 (1)

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

2007 (2)

D. L. Wang, B. V. Hunter, M. J. Cobb, and X. D. Li, IEEE J. Sel. Top. Quantum Electron. 13, 1596 (2007).
[CrossRef]

Z. Hu and A. M. Rollins, Opt. Lett. 32, 3525 (2007).
[CrossRef]

2006 (1)

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

2004 (1)

2001 (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

2000 (2)

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, Gastrointest. Endosc. 51, 467 (2000).
[CrossRef]

X. D. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, Opt. Lett. 25, 1520 (2000).
[CrossRef]

Adler, D. C.

Arruda, M.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Barton, J. K.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Bishop, A.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Bouma, B. E.

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, Gastrointest. Endosc. 51, 467 (2000).
[CrossRef]

Brenner, M.

Carrigan, T.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Chen, Z. P.

Chudoba, C.

Cobb, M. J.

J. F. Xi, L. Huo, Y. C. Wu, M. J. Cobb, J. H. Hwang, and X. D. Li, Opt. Lett. 34, 1943 (2009).
[CrossRef]

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

D. L. Wang, B. V. Hunter, M. J. Cobb, and X. D. Li, IEEE J. Sel. Top. Quantum Electron. 13, 1596 (2007).
[CrossRef]

Compton, C. C.

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, Gastrointest. Endosc. 51, 467 (2000).
[CrossRef]

Drexler, W.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

Fu, H. L.

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

Fujimoto, J. G.

Ghanta, R. K.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

Hariri, L. P.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Hermann, B.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Hsu, K.

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

Hu, Z.

Huang, Q.

Hunter, B. V.

D. L. Wang, B. V. Hunter, M. J. Cobb, and X. D. Li, IEEE J. Sel. Top. Quantum Electron. 13, 1596 (2007).
[CrossRef]

Huo, L.

Hwang, J. H.

J. F. Xi, L. Huo, Y. C. Wu, M. J. Cobb, J. H. Hwang, and X. D. Li, Opt. Lett. 34, 1943 (2009).
[CrossRef]

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

Kang, W.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Kartner, F. X.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

Ko, T.

Leng, Y. X.

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

Li, X. D.

L. Huo, J. F. Xi, Y. C. Wu, and X. D. Li, Opt. Express 18, 14375 (2010).
[CrossRef]

J. F. Xi, L. Huo, Y. C. Wu, M. J. Cobb, J. H. Hwang, and X. D. Li, Opt. Lett. 34, 1943 (2009).
[CrossRef]

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

D. L. Wang, B. V. Hunter, M. J. Cobb, and X. D. Li, IEEE J. Sel. Top. Quantum Electron. 13, 1596 (2007).
[CrossRef]

X. D. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, Opt. Lett. 25, 1520 (2000).
[CrossRef]

Mashimo, H.

McNally, J.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Morgner, U.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

Mukai, D. S.

Nishioka, N. S.

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, Gastrointest. Endosc. 51, 467 (2000).
[CrossRef]

Pitris, C.

Povazay, B.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Rollins, A. M.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Z. Hu and A. M. Rollins, Opt. Lett. 32, 3525 (2007).
[CrossRef]

Rosenthal, N.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Sattmann, H.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Schmitt, J.

Schuman, J. S.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

Tearney, G. J.

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, Gastrointest. Endosc. 51, 467 (2000).
[CrossRef]

Tran, P. H.

Tsai, T. H.

Tumlinson, R.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Unterhuber, A.

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

Wang, D. L.

D. L. Wang, B. V. Hunter, M. J. Cobb, and X. D. Li, IEEE J. Sel. Top. Quantum Electron. 13, 1596 (2007).
[CrossRef]

Wang, H.

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Wu, Y. C.

Xi, J. F.

Zhou, C.

Gastrointest. Endosc. (1)

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, Gastrointest. Endosc. 51, 467 (2000).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

D. L. Wang, B. V. Hunter, M. J. Cobb, and X. D. Li, IEEE J. Sel. Top. Quantum Electron. 13, 1596 (2007).
[CrossRef]

J. Biomed. Opt. (3)

H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, J. Biomed. Opt. 13, 060502 (2008).
[CrossRef]

R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, J. Biomed. Opt. 11, 064003 (2006).
[CrossRef]

H. Wang, W. Kang, T. Carrigan, A. Bishop, N. Rosenthal, M. Arruda, and A. M. Rollins, J. Biomed. Opt. 16, 110505 (2011).
[CrossRef]

Nat. Med. (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, Nat. Med. 7, 502 (2001).
[CrossRef]

Opt. Express (2)

Opt. Lett. (4)

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Figures (3)

Fig. 1.
Fig. 1.

A, schematic of an ultrahigh-resolution OCT imaging catheter utilizing a diffractive lens to alleviate chromatic aberration. B, reflected spectra of the imaging catheters with a diffractive lens (upper panel) and without a diffractive lens (lower panel) when the mirror position was moved from the focal point by 1 Rayleigh range Z R by an optical spectrum analyzer.

Fig. 2.
Fig. 2.

Schematic of the ultrahigh-resolution spectral-domain endoscopic OCT imaging system and the measured point spread function (inset). C, multielement achromatic collimator; CCD, line scan CCD; G, grating; M, mirror; MESL, multielement scan lens; P, linear K mapping prism; PC, polarization controller; PL, polarizer; PP, prism pair; R, fiber-optic rotary joint.

Fig. 3.
Fig. 3.

A, representative 2D circumferential in vivo OCT image of guinea pig esophagus and, B, its corresponding histology micrograph. C and D show 3 × zoomed -in regions of the dotted boxes in A and B, respectively. E is a cutaway view of a 3D OCT image of guinea pig esophagus. SC, stratum corneum; EP, epithelium; LP, lamina propria; MM, muscularis mucosae; SM, submucosa; MP, muscularis propria. Scale bars: 500 μm in A and B; 250 μm in Cand D.

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