Abstract

A new metric representing polarization uniformity is presented. Noise corrected degree of polarization uniformity (DOPU) is computed from polarization-sensitive optical coherence tomography (OCT), and selectively visualizes tissue with the multiple scattering, such as highly pigmented tissues. The new metric is designed to be minimally sensitive to systematic additive noise. The performance of this new metric is analyzed by numerical simulation and in vivo human retinal imaging, using Jones matrix OCT. The new metric exhibited only a small dependency on the signal-to-noise ratio. Selective in vivo visualization of pigmented tissues in the human retina is demonstrated, with cross sectional and en-face images.

© 2014 Optical Society of America

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References

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2014 (1)

Y.-J. Hong, M. Miura, M. J. Ju, S. Makita, T. Iwasaki, and Y. Yasuno, Invest. Ophthalmol. Vis. Sci. 55, 5016 (2014).
[Crossref]

2013 (1)

2012 (1)

2011 (1)

2008 (2)

2007 (2)

2006 (1)

M. Sawa, M. D. Ober, and R. F. Spaide, Retina 26, 119 (2006).
[Crossref]

1972 (1)

G. Marsaglia, Annal. Math. Statist. 43, 645 (1972).
[Crossref]

Adie, S. G.

Ahlers, C.

Baumann, B.

Baumann, S. O.

Cheney, M. C.

Duan, L.

Elsner, A. E.

Fukuda, S.

Geitzenauer, W.

Götzinger, E.

Hillman, T. R.

Hitzenberger, C. K.

Hong, Y.-J.

Y.-J. Hong, M. Miura, M. J. Ju, S. Makita, T. Iwasaki, and Y. Yasuno, Invest. Ophthalmol. Vis. Sci. 55, 5016 (2014).
[Crossref]

M. J. Ju, Y.-J. Hong, S. Makita, Y. Lim, K. Kurokawa, L. Duan, M. Miura, S. Tang, and Y. Yasuno, Opt. Express 21, 19412 (2013).
[Crossref]

Iwasaki, T.

Y.-J. Hong, M. Miura, M. J. Ju, S. Makita, T. Iwasaki, and Y. Yasuno, Invest. Ophthalmol. Vis. Sci. 55, 5016 (2014).
[Crossref]

Ju, M. J.

Y.-J. Hong, M. Miura, M. J. Ju, S. Makita, T. Iwasaki, and Y. Yasuno, Invest. Ophthalmol. Vis. Sci. 55, 5016 (2014).
[Crossref]

M. J. Ju, Y.-J. Hong, S. Makita, Y. Lim, K. Kurokawa, L. Duan, M. Miura, S. Tang, and Y. Yasuno, Opt. Express 21, 19412 (2013).
[Crossref]

Kaji, Y.

Kang, J.-H.

S.-W. Lee, J.-H. Kang, J.-Y. Yoo, M.-S. Kang, J.-T. Oh, and B.-M. Kim, J. Biomed. Opt. 13, 054032 (2008).
[Crossref]

Kang, M.-S.

S.-W. Lee, J.-H. Kang, J.-Y. Yoo, M.-S. Kang, J.-T. Oh, and B.-M. Kim, J. Biomed. Opt. 13, 054032 (2008).
[Crossref]

Kim, B.-M.

S.-W. Lee, J.-H. Kang, J.-Y. Yoo, M.-S. Kang, J.-T. Oh, and B.-M. Kim, J. Biomed. Opt. 13, 054032 (2008).
[Crossref]

Kiuchi, T.

Konegger, T.

Kurokawa, K.

Lee, S.-W.

S.-W. Lee, J.-H. Kang, J.-Y. Yoo, M.-S. Kang, J.-T. Oh, and B.-M. Kim, J. Biomed. Opt. 13, 054032 (2008).
[Crossref]

Lim, Y.

Litschauer, M.

Makita, S.

Y.-J. Hong, M. Miura, M. J. Ju, S. Makita, T. Iwasaki, and Y. Yasuno, Invest. Ophthalmol. Vis. Sci. 55, 5016 (2014).
[Crossref]

M. J. Ju, Y.-J. Hong, S. Makita, Y. Lim, K. Kurokawa, L. Duan, M. Miura, S. Tang, and Y. Yasuno, Opt. Express 21, 19412 (2013).
[Crossref]

Marsaglia, G.

G. Marsaglia, Annal. Math. Statist. 43, 645 (1972).
[Crossref]

Michels, S.

Miura, M.

Ober, M. D.

M. Sawa, M. D. Ober, and R. F. Spaide, Retina 26, 119 (2006).
[Crossref]

Oh, J.-T.

S.-W. Lee, J.-H. Kang, J.-Y. Yoo, M.-S. Kang, J.-T. Oh, and B.-M. Kim, J. Biomed. Opt. 13, 054032 (2008).
[Crossref]

Oshika, T.

Pircher, M.

Sampson, D. D.

Sattmann, H.

Sawa, M.

M. Sawa, M. D. Ober, and R. F. Spaide, Retina 26, 119 (2006).
[Crossref]

Schlanitz, F.

Schmidt-Erfurth, U.

Schütze, C.

Spaide, R. F.

M. Sawa, M. D. Ober, and R. F. Spaide, Retina 26, 119 (2006).
[Crossref]

Tang, S.

VanNasdale, D. A.

Weber, A.

Yamanari, M.

Yasuno, Y.

Yoo, J.-Y.

S.-W. Lee, J.-H. Kang, J.-Y. Yoo, M.-S. Kang, J.-T. Oh, and B.-M. Kim, J. Biomed. Opt. 13, 054032 (2008).
[Crossref]

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Figures (4)

Fig. 1.
Fig. 1. Numerical simulation results of polarization uniformity measurements. Measured results of M-DOPU (blue) and G-DOPU (orange), with set SNR of 5 (solid), 10 (dash), and 15 (dashdot) dB, are shown. Green curve shows the uniformity measurement without noise, g^.
Fig. 2.
Fig. 2. In vivo human retinal image obtained by Jones matrix OCT. Cross sectional polarization uniformity images obtained with (a) G-DOPU, (b) M-DOPU [Eq. (2)], and (c) M-DOPU [Eq. (3)]. (d)–(f) Set of examples with 5 dB SNR penalty for each polarization uniformity measurement.
Fig. 3.
Fig. 3. SNR dependencies of polarization uniformity measurements.
Fig. 4.
Fig. 4. (a) OCT-M-DOPU composite cross section showing the structure of the retina and the location of pigments. (b) OCT en-face projection, (c) fundus autofluorescence, (d) en-face M-DOPU, (e) fluorescence angiography, and (f) en-face OCT angiography employing M-DOPU.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

[s0s1s2s3]=[|gH|2+|gV|2(|nH|2¯+|nV|2¯)|gH|2|gV|2(|nH|2¯|nV|2¯)2Re[gHgV*]2Im[gHgV*]],
DOPU=v=13sv¯2/s0¯,
DOPU=m=1Mw(m)v=13sv(m)¯2/m=1Mw(m)s0(m)¯,

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