Abstract

Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.

© 2014 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography

Yang Zhao, Jason R. Maher, Jina Kim, Maria Angelica Selim, Howard Levinson, and Adam Wax
Biomed. Opt. Express 6(9) 3339-3345 (2015)

In vivo tissue injury mapping using optical coherence tomography based methods

Utku Baran, Yuandong Li, and Ruikang K. Wang
Appl. Opt. 54(21) 6448-6453 (2015)

In vivo burn imaging using Mueller optical coherence tomography

Miloš Todorović, Shuliang Jiao, Jun Ai, David Pereda-Cubián, George Stoica, and Lihong V. Wang
Opt. Express 16(14) 10279-10284 (2008)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (7)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription