Abstract

Spectrally encoded endoscopy is a promising technique for minimally invasive imaging, allowing high-quality imaging through small diameter probes that do not require rapid mechanical scanning. A novel optical configuration that employs broadband visible light and dual-channel imaging is used to demonstrate a miniature forward-viewing probe having a high number of resolvable points, low speckle contrast, negligible backreflections, and high signal-to-noise ratio. The system would be most suitable for imaging through narrow ducts and vessels for clinical diagnosis at hard-to-reach locations in the body.

© 2014 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. G. J. Tearney, M. Shishkov, and B. E. Bouma, Opt. Lett. 27, 412 (2002).
    [CrossRef]
  2. A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
    [CrossRef]
  3. C. Changho, K. Isamoto, and H. Toshiyoshi, IEEE Photon. Technol. Lett. 18, 133 (2006).
    [CrossRef]
  4. E. J. Seibel and Q. Y. J. Smithwick, Lasers Surg. Med. 30, 177 (2002).
    [CrossRef]
  5. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
    [CrossRef]
  6. D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
    [CrossRef]
  7. D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
    [CrossRef]
  8. D. Yelin, B. E. Bouma, and G. J. Tearney, Opt. Express 16, 1748 (2008).
    [CrossRef]
  9. D. Yelin, B. E. Bouma, J. J. Rosowsky, and G. J. Tearney, Opt. Express 16, 14836 (2008).
    [CrossRef]
  10. D. Yelin, B. E. Bouma, S. H. Yun, and G. J. Tearney, Opt. Lett. 29, 2408 (2004).
    [CrossRef]
  11. A. Abramov, L. Minai, and D. Yelin, Opt. Express 18, 14745 (2010).
    [CrossRef]
  12. G. Engel, H. Genish, M. Rosenbluh, and D. Yelin, Biomed. Opt. Express 3, 1855 (2012).
    [CrossRef]
  13. D. Kang, D. Yelin, B. E. Bouma, and G. J. Tearney, Opt. Express 17, 15239 (2009).
    [CrossRef]
  14. D. Yelin, W. M. White, J. T. Motz, S. H. Yun, B. E. Bouma, and G. J. Tearney, Opt. Express 15, 2432 (2007).
    [CrossRef]
  15. D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
    [CrossRef]
  16. D. Yelin, C. Boudoux, B. E. Bounia, and G. J. Tearney, Opt. Lett. 32, 1102 (2007).
    [CrossRef]
  17. A. Abramov, L. Minai, and D. Yelin, Opt. Express 19, 6913 (2011).
    [CrossRef]

2013 (1)

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

2012 (1)

2011 (1)

2010 (2)

A. Abramov, L. Minai, and D. Yelin, Opt. Express 18, 14745 (2010).
[CrossRef]

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

2009 (1)

2008 (2)

2007 (2)

2006 (2)

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

C. Changho, K. Isamoto, and H. Toshiyoshi, IEEE Photon. Technol. Lett. 18, 133 (2006).
[CrossRef]

2005 (1)

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

2004 (1)

2002 (2)

G. J. Tearney, M. Shishkov, and B. E. Bouma, Opt. Lett. 27, 412 (2002).
[CrossRef]

E. J. Seibel and Q. Y. J. Smithwick, Lasers Surg. Med. 30, 177 (2002).
[CrossRef]

1997 (1)

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Abramov, A.

Boppart, S. A.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Boudoux, C.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

D. Yelin, C. Boudoux, B. E. Bounia, and G. J. Tearney, Opt. Lett. 32, 1102 (2007).
[CrossRef]

Bouma, B. E.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

D. Kang, D. Yelin, B. E. Bouma, and G. J. Tearney, Opt. Express 17, 15239 (2009).
[CrossRef]

D. Yelin, B. E. Bouma, J. J. Rosowsky, and G. J. Tearney, Opt. Express 16, 14836 (2008).
[CrossRef]

D. Yelin, B. E. Bouma, and G. J. Tearney, Opt. Express 16, 1748 (2008).
[CrossRef]

D. Yelin, W. M. White, J. T. Motz, S. H. Yun, B. E. Bouma, and G. J. Tearney, Opt. Express 15, 2432 (2007).
[CrossRef]

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

D. Yelin, B. E. Bouma, S. H. Yun, and G. J. Tearney, Opt. Lett. 29, 2408 (2004).
[CrossRef]

G. J. Tearney, M. Shishkov, and B. E. Bouma, Opt. Lett. 27, 412 (2002).
[CrossRef]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Bounia, B. E.

Brezinski, M. E.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Changho, C.

C. Changho, K. Isamoto, and H. Toshiyoshi, IEEE Photon. Technol. Lett. 18, 133 (2006).
[CrossRef]

Delaney, P. M.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

Duan, C.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Engel, G.

Fu, L.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Fujimoto, J. G.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Genish, H.

Gong, Z.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Hasan, T.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

Isamoto, K.

C. Changho, K. Isamoto, and H. Toshiyoshi, IEEE Photon. Technol. Lett. 18, 133 (2006).
[CrossRef]

Jia, H.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Kang, D.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

D. Kang, D. Yelin, B. E. Bouma, and G. J. Tearney, Opt. Express 17, 15239 (2009).
[CrossRef]

Kiesslich, R.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

Lauwers, G. Y.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Ma, J. S.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

McLaren, W. J.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

Minai, L.

Mino-Kenudson, M.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Motz, J. T.

D. Yelin, W. M. White, J. T. Motz, S. H. Yun, B. E. Bouma, and G. J. Tearney, Opt. Express 15, 2432 (2007).
[CrossRef]

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

Neurath, M. F.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

Nishioka, N. S.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Pitris, C.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Polglase, A. L.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

Puricelli, W. P.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Rizvi, I.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

Rosenbluh, M.

Rosowsky, J. J.

Samuelson, S.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Seibel, E. J.

E. J. Seibel and Q. Y. J. Smithwick, Lasers Surg. Med. 30, 177 (2002).
[CrossRef]

Shishkov, M.

Skinner, S. A.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

Smithwick, Q. Y. J.

E. J. Seibel and Q. Y. J. Smithwick, Lasers Surg. Med. 30, 177 (2002).
[CrossRef]

Southern, J. F.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Suter, M. J.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Tearney, G. J.

Toshiyoshi, H.

C. Changho, K. Isamoto, and H. Toshiyoshi, IEEE Photon. Technol. Lett. 18, 133 (2006).
[CrossRef]

Wang, D.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Wang, X.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

White, W. M.

D. Yelin, W. M. White, J. T. Motz, S. H. Yun, B. E. Bouma, and G. J. Tearney, Opt. Express 15, 2432 (2007).
[CrossRef]

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

Xie, H.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Yachimski, P. S.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Yelin, D.

Yoo, H.

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

Yun, S. H.

Biomed. Opt. Express (1)

Gastrointest. Endosc. (2)

D. Kang, M. J. Suter, C. Boudoux, H. Yoo, P. S. Yachimski, W. P. Puricelli, N. S. Nishioka, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, and G. J. Tearney, Gastrointest. Endosc. 71, 35 (2010).
[CrossRef]

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, Gastrointest. Endosc. 62, 686 (2005).
[CrossRef]

IEEE Photon. Technol. Lett. (1)

C. Changho, K. Isamoto, and H. Toshiyoshi, IEEE Photon. Technol. Lett. 18, 133 (2006).
[CrossRef]

J. Biomed. Opt. (1)

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, J. Biomed. Opt. 18, 086005 (2013).
[CrossRef]

Lasers Surg. Med. (1)

E. J. Seibel and Q. Y. J. Smithwick, Lasers Surg. Med. 30, 177 (2002).
[CrossRef]

Nature (1)

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef]

Opt. Express (6)

Opt. Lett. (3)

Science (1)

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1.
Fig. 1.

Forward-viewing SEE system. L1, L2, achromatic lenses; G, transmission grating; EMCCD, electron-multiplying charge-coupled device. Inset: schematic drawing and a photograph of the probe. SMF, single-mode fiber; GRIN, gradient index.

Fig. 2.
Fig. 2.

(a) Image of a 1951 USAF scattering resolution target 7 mm from the distal end of the probe. (b) Same as Fig. 2(a), 4 mm from probe. (c) Same as Fig. 2(a), 10 mm from the probe. Scale bars, 440 μm.

Fig. 3.
Fig. 3.

Imaging a resolution target parallel to the probe axis. (a) Schematic illustration of the imaging configuration. (b) Imaging at different radial displacements from the optical axis. Δy, from top to bottom: 2 mm, 1.6 mm, 1.2 mm.

Fig. 4.
Fig. 4.

(a) 2D raw image acquired during a full rotation of the resolution target. Exposure time was 10 ms per line. (b) Polar coordinates presentation of Fig. 4(a). (c) The same as Fig. 4(b) using exposure time of 10 μs per line.

Metrics