Abstract

We propose and demonstrate a novel fiber bundle imaging based on spatial compounding induced by random transverse motion to remove the pixelation effect, to improve resolution, and to increase image quality. The experimental results using a USAF target and pyramidal neuron cell showed that 20-frame compounding improved image quality (contrast-to-noise ratio by >9  dB, global SNR by >6  dB, equivalent number of looks by >1.8  times, and 1/β by >1.5  times), resolution by better than 2 μm, and completely eliminated pixelation artifact.

© 2014 Optical Society of America

PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. F. Gmitro and A. R. Rouse, Opt. Photon. News 20(11), 28 (2009).
    [CrossRef]
  2. B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
    [CrossRef]
  3. K. L. Reichenbach and C. Xu, Opt. Express 15, 2151 (2007).
    [CrossRef]
  4. J.-H. Han and J. U. Kang, Appl. Phys. B 106, 635 (2012).
    [CrossRef]
  5. B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
    [CrossRef]
  6. S. Rupp, C. Winter, and M. Elter, in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE, 2009), pp. 3677–3680.
  7. J.-H. Han, J. Lee, and J. U. Kang, Opt. Express 18, 7427 (2010).
    [CrossRef]
  8. C. Lee and J.-H. Han, Opt. Lett. 38, 2023 (2013).
    [CrossRef]
  9. M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
    [CrossRef]
  10. N. Bedard and T. S. Tkaczyk, J. Biomed. Opt. 17, 080508 (2012).
    [CrossRef]
  11. T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).
  12. Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).
  13. W. Wang and F. Chang, J. Comput. 6, 2559 (2011).
    [CrossRef]
  14. S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
    [CrossRef]
  15. X. Liu, Y. Huang, and J. U. Kang, J. Biomed. Opt. 16, 046003 (2011).
    [CrossRef]
  16. K. Briechle and U. D. Hanebeck, Proc. SPIE 4387, 95 (2001).
    [CrossRef]
  17. D. C. Adler, T. H. Ko, and J. G. Fujimoto, Opt. Lett. 29, 2878 (2004).
    [CrossRef]
  18. F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
    [CrossRef]

2014 (2)

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

2013 (1)

2012 (2)

J.-H. Han and J. U. Kang, Appl. Phys. B 106, 635 (2012).
[CrossRef]

N. Bedard and T. S. Tkaczyk, J. Biomed. Opt. 17, 080508 (2012).
[CrossRef]

2011 (2)

W. Wang and F. Chang, J. Comput. 6, 2559 (2011).
[CrossRef]

X. Liu, Y. Huang, and J. U. Kang, J. Biomed. Opt. 16, 046003 (2011).
[CrossRef]

2010 (2)

J.-H. Han, J. Lee, and J. U. Kang, Opt. Express 18, 7427 (2010).
[CrossRef]

M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
[CrossRef]

2009 (1)

A. F. Gmitro and A. R. Rouse, Opt. Photon. News 20(11), 28 (2009).
[CrossRef]

2008 (1)

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

2007 (1)

2006 (1)

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

2005 (1)

B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
[CrossRef]

2004 (1)

2001 (1)

K. Briechle and U. D. Hanebeck, Proc. SPIE 4387, 95 (2001).
[CrossRef]

1997 (1)

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Adler, D. C.

Ayache, N.

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

Barretto, R. P. J.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Bedard, N.

N. Bedard and T. S. Tkaczyk, J. Biomed. Opt. 17, 080508 (2012).
[CrossRef]

Bovik, A. C.

B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
[CrossRef]

Briechle, K.

K. Briechle and U. D. Hanebeck, Proc. SPIE 4387, 95 (2001).
[CrossRef]

Burns, L. D.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Carlson, K. D.

B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
[CrossRef]

Chang, F.

W. Wang and F. Chang, J. Comput. 6, 2559 (2011).
[CrossRef]

Cheon, G. W.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Chien, W.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Choi, W.

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

Choi, Y.

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

Cocker, E. D.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Elter, M.

S. Rupp, C. Winter, and M. Elter, in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE, 2009), pp. 3677–3680.

Floreby, L.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Flusberg, B. A.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Fujimoto, J. G.

Gmitro, A. F.

A. F. Gmitro and A. R. Rouse, Opt. Photon. News 20(11), 28 (2009).
[CrossRef]

Gonenc, B.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Gurbani, S. S.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Han, J.-H.

Hanebeck, U. D.

K. Briechle and U. D. Hanebeck, Proc. SPIE 4387, 95 (2001).
[CrossRef]

Huang, Y.

X. Liu, Y. Huang, and J. U. Kang, J. Biomed. Opt. 16, 046003 (2011).
[CrossRef]

Iordachita, I. I.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Jung, J. C.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Kang, J. U.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

J.-H. Han and J. U. Kang, Appl. Phys. B 106, 635 (2012).
[CrossRef]

X. Liu, Y. Huang, and J. U. Kang, J. Biomed. Opt. 16, 046003 (2011).
[CrossRef]

J.-H. Han, J. Lee, and J. U. Kang, Opt. Express 18, 7427 (2010).
[CrossRef]

Kester, R.

M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
[CrossRef]

Kim, M.

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

Ko, T. H.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

D. C. Adler, T. H. Ko, and J. G. Fujimoto, Opt. Lett. 29, 2878 (2004).
[CrossRef]

Kyrish, M.

M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
[CrossRef]

Lee, C.

Lee, J.

Liu, X.

X. Liu, Y. Huang, and J. U. Kang, J. Biomed. Opt. 16, 046003 (2011).
[CrossRef]

Lovstrom, B.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Luck, B. L.

B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
[CrossRef]

Malandain, G.

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

Mukamel, E. A.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Nimmerjahn, A.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Niparko, J. K.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Pennec, X.

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

Perchant, A.

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

Reichenbach, K. L.

Richards-Kortum, R.

M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
[CrossRef]

Richards-Kortum, R. R.

B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
[CrossRef]

Rouse, A. R.

A. F. Gmitro and A. R. Rouse, Opt. Photon. News 20(11), 28 (2009).
[CrossRef]

Rupp, S.

S. Rupp, C. Winter, and M. Elter, in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE, 2009), pp. 3677–3680.

Salomonsson, G.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Sattar, F.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Schnitzer, M. J.

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Taylor, R. H.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Tkaczyk, T.

M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
[CrossRef]

Tkaczyk, T. S.

N. Bedard and T. S. Tkaczyk, J. Biomed. Opt. 17, 080508 (2012).
[CrossRef]

Vercauteren, T.

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

Wang, W.

W. Wang and F. Chang, J. Comput. 6, 2559 (2011).
[CrossRef]

Wilkening, P.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Winter, C.

S. Rupp, C. Winter, and M. Elter, in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE, 2009), pp. 3677–3680.

Xu, C.

Yoon, C.

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

Zhao, M.

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

Appl. Phys. B (1)

J.-H. Han and J. U. Kang, Appl. Phys. B 106, 635 (2012).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

Y. Choi, C. Yoon, M. Kim, W. Choi, and W. Choi, IEEE J. Sel. Top. Quantum Electron. 20, 6800213 (2014).

IEEE Trans. Image Process. (2)

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

B. L. Luck, K. D. Carlson, A. C. Bovik, and R. R. Richards-Kortum, IEEE Trans. Image Process. 14, 1265 (2005).
[CrossRef]

J. Biomed. Opt. (3)

N. Bedard and T. S. Tkaczyk, J. Biomed. Opt. 17, 080508 (2012).
[CrossRef]

S. S. Gurbani, P. Wilkening, M. Zhao, B. Gonenc, G. W. Cheon, I. I. Iordachita, W. Chien, R. H. Taylor, J. K. Niparko, and J. U. Kang, J. Biomed. Opt. 19, 057004 (2014).
[CrossRef]

X. Liu, Y. Huang, and J. U. Kang, J. Biomed. Opt. 16, 046003 (2011).
[CrossRef]

J. Comput. (1)

W. Wang and F. Chang, J. Comput. 6, 2559 (2011).
[CrossRef]

Med. Image Anal. (1)

T. Vercauteren, A. Perchant, G. Malandain, X. Pennec, and N. Ayache, Med. Image Anal. 10, 673 (2006).

Nat. Methods (1)

B. A. Flusberg, A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef]

Opt. Express (2)

Opt. Lett. (2)

Opt. Photon. News (1)

A. F. Gmitro and A. R. Rouse, Opt. Photon. News 20(11), 28 (2009).
[CrossRef]

Proc. SPIE (2)

K. Briechle and U. D. Hanebeck, Proc. SPIE 4387, 95 (2001).
[CrossRef]

M. Kyrish, R. Kester, R. Richards-Kortum, and T. Tkaczyk, Proc. SPIE 7558, 755807 (2010).
[CrossRef]

Other (1)

S. Rupp, C. Winter, and M. Elter, in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE, 2009), pp. 3677–3680.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Metrics