Abstract

We interrogated whether optoacoustic tomography could be employed to study blood functional parameters and biodistribution of injected fluorescent agents in humans. Using a multichannel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger in real time, before and after the administration of indocyanine green. We demonstrated that multispectral optoacoustic tomography can sense fast flow kinetics and resolve spatiotemporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer.

© 2014 Optical Society of America

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L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

K. Jansen, M. Wu, A. F. W. van der Steen, and G. van Soest, Photoacoustics 2, 12 (2014).
[CrossRef]

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

2013 (2)

X. L. Deán-Ben and D. Razansky, Photoacoustics 1, 68 (2013).
[CrossRef]

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013).
[CrossRef]

2012 (4)

M. Heijblom, D. Piras, W. Xia, J. van Hespen, J. Klaase, F. van den Engh, T. van Leeuwen, W. Steenbergen, and S. Manohar, Opt. Express 20, 11582 (2012).
[CrossRef]

A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

D. Razansky, IEEE J. Sel. Topics Quantum Electron. 18, 1234 (2012).

2011 (2)

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

Y. Sun, E. S. Sobel, and H. Jiang, Med. Phys. 38, 4009 (2011).
[CrossRef]

2010 (2)

V. Ntziachristos, Nat. Methods 7, 603 (2010).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 29, 1275 (2010).
[CrossRef]

2009 (2)

2005 (1)

2003 (1)

2000 (2)

S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000).
[CrossRef]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, Proc. Natl. Acad. Sci. USA 97, 2767 (2000).

1997 (1)

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

1989 (1)

J. M. Kleinert, S. G. Fleming, C. S. Abel, and J. Firrell, J. Hand Surg. 14, 504 (1989).

1987 (1)

B. M. Leslie, L. K. Ruby, S. J. Madell, and F. Wittenstein, J. Hand Surg. 12, 740 (1987).

1976 (1)

M. Landsman, G. Kwant, G. Mook, and W. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

1960 (1)

G. R. Cherrick, S. W. Stein, C. M. Leevy, and C. S. Davidson, J. Clin. Invest. 39, 592 (1960).
[CrossRef]

1950 (1)

G. C. Sutton, J. Karnell, and G. Nylin, Am. Heart J. 39, 741 (1950).
[CrossRef]

Abel, C. S.

J. M. Kleinert, S. G. Fleming, C. S. Abel, and J. Firrell, J. Hand Surg. 14, 504 (1989).

Ahari, C.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Ambrose, M.

Aoyagi, T.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Beard, P.

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

Buehler, A.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

Burk, S. E.

S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000).
[CrossRef]

Carson, P. L.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013).
[CrossRef]

Chance, B.

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, Proc. Natl. Acad. Sci. USA 97, 2767 (2000).

Cherrick, G. R.

G. R. Cherrick, S. W. Stein, C. M. Leevy, and C. S. Davidson, J. Clin. Invest. 39, 592 (1960).
[CrossRef]

Choi, B.

Da Mata, A. P.

S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000).
[CrossRef]

Davidson, C. S.

G. R. Cherrick, S. W. Stein, C. M. Leevy, and C. S. Davidson, J. Clin. Invest. 39, 592 (1960).
[CrossRef]

Deán-Ben, X. L.

X. L. Deán-Ben and D. Razansky, Photoacoustics 1, 68 (2013).
[CrossRef]

Dima, A.

Dorn, F.

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Ermolayev, V.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

Firrell, J.

J. M. Kleinert, S. G. Fleming, C. S. Abel, and J. Firrell, J. Hand Surg. 14, 504 (1989).

Fleming, S. G.

J. M. Kleinert, S. G. Fleming, C. S. Abel, and J. Firrell, J. Hand Surg. 14, 504 (1989).

Foster, R. E.

S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000).
[CrossRef]

Fowlkes, J. B.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013).
[CrossRef]

Fuse, M.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Ganter, C.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

Gateau, J.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

Girish, G.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013).
[CrossRef]

Golovko, D.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Haller, B.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

Heijblom, M.

Iijima, T.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Iwao, Y.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Jansen, K.

K. Jansen, M. Wu, A. F. W. van der Steen, and G. van Soest, Photoacoustics 2, 12 (2014).
[CrossRef]

Jiang, H.

Y. Sun, E. S. Sobel, and H. Jiang, Med. Phys. 38, 4009 (2011).
[CrossRef]

Kaplan, M. J.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013).
[CrossRef]

Karnell, J.

G. C. Sutton, J. Karnell, and G. Nylin, Am. Heart J. 39, 741 (1950).
[CrossRef]

Klaase, J.

Kleinert, J. M.

J. M. Kleinert, S. G. Fleming, C. S. Abel, and J. Firrell, J. Hand Surg. 14, 504 (1989).

Kobayashi, N.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Ku, G.

Kwant, G.

M. Landsman, G. Kwant, G. Mook, and W. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Landsman, M.

M. Landsman, G. Kwant, G. Mook, and W. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Leevy, C. M.

G. R. Cherrick, S. W. Stein, C. M. Leevy, and C. S. Davidson, J. Clin. Invest. 39, 592 (1960).
[CrossRef]

Leslie, B. M.

B. M. Leslie, L. K. Ruby, S. J. Madell, and F. Wittenstein, J. Hand Surg. 12, 740 (1987).

Madell, S. J.

B. M. Leslie, L. K. Ruby, S. J. Madell, and F. Wittenstein, J. Hand Surg. 12, 740 (1987).

Manohar, S.

Maslov, K.

Masuda, J.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Meier, R.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Moog, P.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Mook, G.

M. Landsman, G. Kwant, G. Mook, and W. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Morel, J.-M.

J.-M. Morel and G. Yu, SIAM J. Imaging Sci. 2, 438 (2009).
[CrossRef]

Nasirudin, R. A.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

Nelson, J. S.

Noël, P. B.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Ntziachristos, V.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 29, 1275 (2010).
[CrossRef]

V. Ntziachristos, Nat. Methods 7, 603 (2010).
[CrossRef]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, Proc. Natl. Acad. Sci. USA 97, 2767 (2000).

Nylin, G.

G. C. Sutton, J. Karnell, and G. Nylin, Am. Heart J. 39, 741 (1950).
[CrossRef]

Piras, D.

Rajian, J. R.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013).
[CrossRef]

Razansky, D.

X. L. Deán-Ben and D. Razansky, Photoacoustics 1, 68 (2013).
[CrossRef]

D. Razansky, IEEE J. Sel. Topics Quantum Electron. 18, 1234 (2012).

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 29, 1275 (2010).
[CrossRef]

Rosa, R. H.

S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000).
[CrossRef]

Rosenthal, A.

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 29, 1275 (2010).
[CrossRef]

Ruby, L. K.

B. M. Leslie, L. K. Ruby, S. J. Madell, and F. Wittenstein, J. Hand Surg. 12, 740 (1987).

Rummeny, E. J.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

Sankawa, H.

T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997).
[CrossRef]

Schaeffeler, C.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Schnall, M.

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, Proc. Natl. Acad. Sci. USA 97, 2767 (2000).

Schwarz, M.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

Shung, K. K.

Sievert, M.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Snyder, M. E.

S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000).
[CrossRef]

Sobel, E. S.

Y. Sun, E. S. Sobel, and H. Jiang, Med. Phys. 38, 4009 (2011).
[CrossRef]

Spanier, J.

Steenbergen, W.

Stein, S. W.

G. R. Cherrick, S. W. Stein, C. M. Leevy, and C. S. Davidson, J. Clin. Invest. 39, 592 (1960).
[CrossRef]

Sun, Y.

Y. Sun, E. S. Sobel, and H. Jiang, Med. Phys. 38, 4009 (2011).
[CrossRef]

Sutton, G. C.

G. C. Sutton, J. Karnell, and G. Nylin, Am. Heart J. 39, 741 (1950).
[CrossRef]

Thuermel, K.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

Thürmel, K.

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

van den Engh, F.

van der Steen, A. F. W.

K. Jansen, M. Wu, A. F. W. van der Steen, and G. van Soest, Photoacoustics 2, 12 (2014).
[CrossRef]

van Hespen, J.

van Leeuwen, T.

van Soest, G.

K. Jansen, M. Wu, A. F. W. van der Steen, and G. van Soest, Photoacoustics 2, 12 (2014).
[CrossRef]

Viator, J. A.

Vionnet, L.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014).
[CrossRef]

Waldt, S.

R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014).
[CrossRef]

R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012).
[CrossRef]

Wang, L. H. V.

Wang, L. V.

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: For Safe Use of Lasers. Published by the Laser Institute of America.

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Figures (3)

Fig. 1.
Fig. 1.

Sketch of the setup used for cross-sectional optoacoustic tomography of human peripheral joints in vivo. The finger to be imaged was in a stretched position and immobilized by an adaptable holder system during the experiment. Our system with a parallel detection array allowed rendering 10 cross-sectional optoacoustic images of the finger every second.

Fig. 2.
Fig. 2.

(a) Cross-sectional optoacoustic reconstruction of the index finger of a healthy volunteer imaged at the PIP joint using 730 nm excitation wavelength. (b) Corresponding reconstruction at 850 nm. (c) Oxygen saturation map (shown in color) overlaid on top of the single-wavelength (anatomical) optoacoustic image at 790 nm (shown in grayscale). (d) Corresponding MRI slice acquired before the optoacoustic experiments.

Fig. 3.
Fig. 3.

Optoacoustic monitoring of intravenous injection of ICG contrast agent. (a) Cross-sectional optoacoustic image of the finger before injection. (b) Corresponding image 30 s after injection of ICG. (c) Intensity profile of Vessel 1 and Vessel 2 (indicated by the blue and red rectangles in (a) and (b)) over 180 s. Characteristic time constants were calculated for both vessels (black-dashed lines and arrows).

Equations (1)

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f(t)=A1·exp(t/T1)A2·exp(t/T2)+B0

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