Abstract

We demonstrated a mechanical iris-based fiber optic probe with adjustable spatial offsets for spatially offset Raman spectroscopy (SORS). In the fiber probe, the excitation fiber was fixed at the center of the iris, and the collection fibers were movable with blades of the iris. Moreover, we studied the gap effect between the probe and the sample and demonstrated this fiber optic probe can be used as a platform for surface-enhanced SORS applications. This fiber probe design could potentially provide a design-efficient and cost-effective solution for various Raman applications.

© 2014 Optical Society of America

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  1. C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
    [CrossRef]
  2. N. Stone and C. A. Kendall, Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields (Springer, 2010).
  3. H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
    [CrossRef]
  4. H. Abramczyk and B. Brozek-Pluska, Chem. Rev. 113, 5766 (2013).
    [CrossRef]
  5. M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
    [CrossRef]
  6. P. Matousek and N. Stone, J. Biophotonics 6, 7 (2013).
    [CrossRef]
  7. P. Matousek, Chem. Soc. Rev. 36, 1292 (2007).
    [CrossRef]
  8. N. A. Macleod and P. Matousek, Appl. Spectrosc. 62, 291A (2008).
    [CrossRef]
  9. J. H. Demers, Sc. C. Davis, B. W. Pogue, and M. D. Morris, Biomed. Opt. Express 3, 2299 (2012).
    [CrossRef]
  10. K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
    [CrossRef]
  11. M. D. Morris and G. S. Mandair, Clin. Orthop. Relat. Res. 469, 2160 (2011).
    [CrossRef]
  12. N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
    [CrossRef]
  13. M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
    [CrossRef]
  14. G. Yodh and D. A. Boas, Biomedical Photonics (CRC Press, 2003).
  15. C. Zhou, “In vivo optical imaging and spectroscopy of cerebral hemodynamics,” Ph.D. thesis (University of Pennsylvania, 2007).
  16. B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
    [CrossRef]
  17. H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
    [CrossRef]

2013

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

H. Abramczyk and B. Brozek-Pluska, Chem. Rev. 113, 5766 (2013).
[CrossRef]

P. Matousek and N. Stone, J. Biophotonics 6, 7 (2013).
[CrossRef]

B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
[CrossRef]

2012

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

J. H. Demers, Sc. C. Davis, B. W. Pogue, and M. D. Morris, Biomed. Opt. Express 3, 2299 (2012).
[CrossRef]

H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
[CrossRef]

2011

K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
[CrossRef]

M. D. Morris and G. S. Mandair, Clin. Orthop. Relat. Res. 469, 2160 (2011).
[CrossRef]

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

2010

N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
[CrossRef]

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

2008

2007

P. Matousek, Chem. Soc. Rev. 36, 1292 (2007).
[CrossRef]

Abramczyk, H.

H. Abramczyk and B. Brozek-Pluska, Chem. Rev. 113, 5766 (2013).
[CrossRef]

Barr, H.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

Boas, D. A.

G. Yodh and D. A. Boas, Biomedical Photonics (CRC Press, 2003).

Brozek-Pluska, B.

H. Abramczyk and B. Brozek-Pluska, Chem. Rev. 113, 5766 (2013).
[CrossRef]

Cohen, J.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Davis, Sc. C.

Demers, J. H.

Drauch, A.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Esmonde-White, F. W. L.

K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
[CrossRef]

Esmonde-White, K. A.

K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
[CrossRef]

Faulds, K.

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
[CrossRef]

Frank, I.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Glucksberg, M. R.

B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
[CrossRef]

Graham, D.

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
[CrossRef]

Granja, N.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Hernandez-Santana, A.

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

Hutchings, J.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

Kallaway, C.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

Keller, M. D.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Kelley, M. C.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Kendall, C.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

Kendall, C. A.

N. Stone and C. A. Kendall, Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields (Springer, 2010).

Lui, H.

H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
[CrossRef]

Ma, K.

B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
[CrossRef]

Macleod, N. A.

Magera, J.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Mahadevan-Jansen, A.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Maier, J.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Mandair, G. S.

M. D. Morris and G. S. Mandair, Clin. Orthop. Relat. Res. 469, 2160 (2011).
[CrossRef]

Matousek, P.

P. Matousek and N. Stone, J. Biophotonics 6, 7 (2013).
[CrossRef]

N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
[CrossRef]

N. A. Macleod and P. Matousek, Appl. Spectrosc. 62, 291A (2008).
[CrossRef]

P. Matousek, Chem. Soc. Rev. 36, 1292 (2007).
[CrossRef]

Max Almond, L.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

McLean, D.

H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
[CrossRef]

Morris, M. D.

J. H. Demers, Sc. C. Davis, B. W. Pogue, and M. D. Morris, Biomed. Opt. Express 3, 2299 (2012).
[CrossRef]

K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
[CrossRef]

M. D. Morris and G. S. Mandair, Clin. Orthop. Relat. Res. 469, 2160 (2011).
[CrossRef]

Mycek, M. A.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Pogue, B. W.

Roessler, B. J.

K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
[CrossRef]

Sebo, T.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Sharma, B.

B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
[CrossRef]

Stevenson, R.

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

Stone, N.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

P. Matousek and N. Stone, J. Biophotonics 6, 7 (2013).
[CrossRef]

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
[CrossRef]

N. Stone and C. A. Kendall, Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields (Springer, 2010).

Tollefson, M.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Van Duyne, R. P.

B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
[CrossRef]

Vargis, E.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Wilson, R. H.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

Wood, J.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

Xie, H.

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

Yodh, G.

G. Yodh and D. A. Boas, Biomedical Photonics (CRC Press, 2003).

Zeng, H.

H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
[CrossRef]

Zhao, J.

H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
[CrossRef]

Zhou, C.

C. Zhou, “In vivo optical imaging and spectroscopy of cerebral hemodynamics,” Ph.D. thesis (University of Pennsylvania, 2007).

Anal. Chem.

N. Stone, K. Faulds, D. Graham, and P. Matousek, Anal. Chem. 82, 3969 (2010).
[CrossRef]

Analyst

K. A. Esmonde-White, F. W. L. Esmonde-White, M. D. Morris, and B. J. Roessler, Analyst 136, 1675 (2011).
[CrossRef]

Angew. Chem.

H. Xie, R. Stevenson, N. Stone, A. Hernandez-Santana, K. Faulds, and D. Graham, Angew. Chem. 124, 8637 (2012).
[CrossRef]

Appl. Spectrosc.

Biomed. Opt. Express

BJU Int.

M. Tollefson, J. Magera, T. Sebo, J. Cohen, A. Drauch, J. Maier, and I. Frank, BJU Int. 106, 484 (2010).
[CrossRef]

Cancer Res.

H. Lui, J. Zhao, D. McLean, and H. Zeng, Cancer Res. 72, 2491 (2012).
[CrossRef]

Chem. Rev.

H. Abramczyk and B. Brozek-Pluska, Chem. Rev. 113, 5766 (2013).
[CrossRef]

Chem. Soc. Rev.

P. Matousek, Chem. Soc. Rev. 36, 1292 (2007).
[CrossRef]

Clin. Orthop. Relat. Res.

M. D. Morris and G. S. Mandair, Clin. Orthop. Relat. Res. 469, 2160 (2011).
[CrossRef]

J. Am. Chem. Soc.

B. Sharma, K. Ma, M. R. Glucksberg, and R. P. Van Duyne, J. Am. Chem. Soc. 135, 17290 (2013).
[CrossRef]

J. Biomed. Opt.

M. D. Keller, E. Vargis, N. Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, J. Biomed. Opt. 16, 077006 (2011).
[CrossRef]

J. Biophotonics

P. Matousek and N. Stone, J. Biophotonics 6, 7 (2013).
[CrossRef]

Photodiagn. Photodyn. Ther.

C. Kallaway, L. Max Almond, H. Barr, J. Wood, J. Hutchings, C. Kendall, and N. Stone, Photodiagn. Photodyn. Ther. 10, 207 (2013).
[CrossRef]

Other

N. Stone and C. A. Kendall, Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields (Springer, 2010).

G. Yodh and D. A. Boas, Biomedical Photonics (CRC Press, 2003).

C. Zhou, “In vivo optical imaging and spectroscopy of cerebral hemodynamics,” Ph.D. thesis (University of Pennsylvania, 2007).

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