Abstract

We report on the optical excitation and detection of resonant microbubble oscillations. Optically absorbing nanoparticles were attached to the shell of a lipid-encapsulated microbubble, allowing for optical pulsing to photothermally drive the microbubble into resonance. A modified optical microscope was used to track the bubble wall radius as a function of time using light scattering. The microbubble response from a nanosecond laser pulse was measured, and the eigenfrequency and vibrational amplitude were determined and compared to theory. The ability to optically drive microbubble oscillations may have applications in basic studies of bubble dynamics and biomedical imaging and therapy.

© 2014 Optical Society of America

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2014

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

2013

J. D. Dove, T. W. Murray, and M. A. Borden, Soft Matter 9, 7743 (2013).
[CrossRef]

2012

Y. H. Wang, A. H. Liao, J. H. Chen, C. R. C. Wang, and P. C. Li, J. Biomed. Opt. 17, 0450011 (2012).

Y. Inaba and J. R. Lindner, Transl. Res. 159, 140 (2012).
[CrossRef]

S. R. Sirsi and M. A. Borden, Theranostics 2, 1208 (2012).

J. A. Feshitan, F. Vlachos, S. R. Sirsi, E. E. Konofagou, and M. A. Borden, Biomaterials 33, 247 (2012).
[CrossRef]

2011

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
[CrossRef]

2010

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

C. C. Chen and M. A. Borden, Langmuir 26, 13183 (2010).
[CrossRef]

J. J. Kwan and M. A. Borden, Langmuir 26, 6542 (2010).
[CrossRef]

C. Kim, R. Qin, J. S. Xu, L. V. Wang, and R. Xu, J. Biomed. Opt. 15, 010510 (2010).
[CrossRef]

2009

S. Qin, C. F. Caskey, and K. W. Ferrara, Phys. Med. Biol. 54, R27 (2009).

K. Sarkar, A. Katiyar, and P. Jain, Ultrasound Med. Biol. 35, 1385 (2009).
[CrossRef]

F. Yang, Y. Li, Z. Chen, Y. Zhang, J. Wu, and N. Gu, Biomaterials 30, 3882 (2009).
[CrossRef]

B. Yuan, Y. Li, P. M. Mehl, and J. Vifnola, Appl. Phys. Lett. 95, 181113 (2009).
[CrossRef]

D. Lapotko, Opt. Express 17, 2538 (2009).
[CrossRef]

2007

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

2005

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

2004

J. Guan and T. J. Matula, J. Acoust. Soc. Am. 116, 2832 (2004).
[CrossRef]

E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, Adv. Drug Deliv. Rev. 56, 1291 (2004).

2000

P. J. A. Frinking, A. Bouakaz, J. Kirkhorn, F. J. Ten Cate, and N. de Jong, Ultrasound Med. Biol. 26, 965 (2000).
[CrossRef]

1990

Borden, M. A.

J. D. Dove, T. W. Murray, and M. A. Borden, Soft Matter 9, 7743 (2013).
[CrossRef]

S. R. Sirsi and M. A. Borden, Theranostics 2, 1208 (2012).

J. A. Feshitan, F. Vlachos, S. R. Sirsi, E. E. Konofagou, and M. A. Borden, Biomaterials 33, 247 (2012).
[CrossRef]

J. J. Kwan and M. A. Borden, Langmuir 26, 6542 (2010).
[CrossRef]

C. C. Chen and M. A. Borden, Langmuir 26, 13183 (2010).
[CrossRef]

Bouakaz, A.

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

P. J. A. Frinking, A. Bouakaz, J. Kirkhorn, F. J. Ten Cate, and N. de Jong, Ultrasound Med. Biol. 26, 965 (2000).
[CrossRef]

Caskey, C. F.

S. Qin, C. F. Caskey, and K. W. Ferrara, Phys. Med. Biol. 54, R27 (2009).

Chen, C. C.

C. C. Chen and M. A. Borden, Langmuir 26, 13183 (2010).
[CrossRef]

Chen, J. H.

Y. H. Wang, A. H. Liao, J. H. Chen, C. R. C. Wang, and P. C. Li, J. Biomed. Opt. 17, 0450011 (2012).

Chen, Z.

F. Yang, Y. Li, Z. Chen, Y. Zhang, J. Wu, and N. Gu, Biomaterials 30, 3882 (2009).
[CrossRef]

Chin, C. T.

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

Cojoc, D.

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

Crum, L. A.

Culp, W.

E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, Adv. Drug Deliv. Rev. 56, 1291 (2004).

de Jong, N.

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
[CrossRef]

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

P. J. A. Frinking, A. Bouakaz, J. Kirkhorn, F. J. Ten Cate, and N. de Jong, Ultrasound Med. Biol. 26, 965 (2000).
[CrossRef]

Di Fabrizio, E.

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

Dollet, B.

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
[CrossRef]

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

Dove, J. D.

J. D. Dove, T. W. Murray, and M. A. Borden, Soft Matter 9, 7743 (2013).
[CrossRef]

Emmer, M.

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

Ferrara, K. W.

S. Qin, C. F. Caskey, and K. W. Ferrara, Phys. Med. Biol. 54, R27 (2009).

Ferrari, E.

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

Feshitan, J. A.

J. A. Feshitan, F. Vlachos, S. R. Sirsi, E. E. Konofagou, and M. A. Borden, Biomaterials 33, 247 (2012).
[CrossRef]

Forsberg, F.

B. B. Goldberg, J. Raichlen, and F. Forsberg, Ultrasound Contrast Agents: Basic Principles and Clinical Applications, 2nd ed. (Dunitz, 2001).

Frinking, P. J. A.

P. J. A. Frinking, A. Bouakaz, J. Kirkhorn, F. J. Ten Cate, and N. de Jong, Ultrasound Med. Biol. 26, 965 (2000).
[CrossRef]

Garbin, V.

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
[CrossRef]

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

Goertz, D. E.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Goldberg, B. B.

B. B. Goldberg, J. Raichlen, and F. Forsberg, Ultrasound Contrast Agents: Basic Principles and Clinical Applications, 2nd ed. (Dunitz, 2001).

Gu, N.

F. Yang, Y. Li, Z. Chen, Y. Zhang, J. Wu, and N. Gu, Biomaterials 30, 3882 (2009).
[CrossRef]

Guan, J.

J. Guan and T. J. Matula, J. Acoust. Soc. Am. 116, 2832 (2004).
[CrossRef]

Helfield, B. L.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Hilgenfeldt, S.

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

Holt, R. G.

Huynh, E.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Inaba, Y.

Y. Inaba and J. R. Lindner, Transl. Res. 159, 140 (2012).
[CrossRef]

Jain, P.

K. Sarkar, A. Katiyar, and P. Jain, Ultrasound Med. Biol. 35, 1385 (2009).
[CrossRef]

Jeon, M.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Katiyar, A.

K. Sarkar, A. Katiyar, and P. Jain, Ultrasound Med. Biol. 35, 1385 (2009).
[CrossRef]

Kim, C.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

C. Kim, R. Qin, J. S. Xu, L. V. Wang, and R. Xu, J. Biomed. Opt. 15, 010510 (2010).
[CrossRef]

Kim, J.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Kirkhorn, J.

P. J. A. Frinking, A. Bouakaz, J. Kirkhorn, F. J. Ten Cate, and N. de Jong, Ultrasound Med. Biol. 26, 965 (2000).
[CrossRef]

Konofagou, E. E.

J. A. Feshitan, F. Vlachos, S. R. Sirsi, E. E. Konofagou, and M. A. Borden, Biomaterials 33, 247 (2012).
[CrossRef]

Kwan, J. J.

J. J. Kwan and M. A. Borden, Langmuir 26, 6542 (2010).
[CrossRef]

Labell, R.

E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, Adv. Drug Deliv. Rev. 56, 1291 (2004).

Lapotko, D.

Leighton, T.

T. Leighton, The Acoustic Bubble (Academic, 1994).

Leung, B. Y. C.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Li, P. C.

Y. H. Wang, A. H. Liao, J. H. Chen, C. R. C. Wang, and P. C. Li, J. Biomed. Opt. 17, 0450011 (2012).

Li, Y.

B. Yuan, Y. Li, P. M. Mehl, and J. Vifnola, Appl. Phys. Lett. 95, 181113 (2009).
[CrossRef]

F. Yang, Y. Li, Z. Chen, Y. Zhang, J. Wu, and N. Gu, Biomaterials 30, 3882 (2009).
[CrossRef]

Liao, A. H.

Y. H. Wang, A. H. Liao, J. H. Chen, C. R. C. Wang, and P. C. Li, J. Biomed. Opt. 17, 0450011 (2012).

Lindner, J. R.

Y. Inaba and J. R. Lindner, Transl. Res. 159, 140 (2012).
[CrossRef]

Lohse, D.

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
[CrossRef]

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

Lovell, J.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Marmottant, P.

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

Matsunaga, T.

E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, Adv. Drug Deliv. Rev. 56, 1291 (2004).

Matula, T. J.

J. Guan and T. J. Matula, J. Acoust. Soc. Am. 116, 2832 (2004).
[CrossRef]

Mehl, P. M.

B. Yuan, Y. Li, P. M. Mehl, and J. Vifnola, Appl. Phys. Lett. 95, 181113 (2009).
[CrossRef]

Murray, T. W.

J. D. Dove, T. W. Murray, and M. A. Borden, Soft Matter 9, 7743 (2013).
[CrossRef]

Oh, J.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Overvelde, M.

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
[CrossRef]

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

Overvelde, M. L. J.

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

Porter, T.

E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, Adv. Drug Deliv. Rev. 56, 1291 (2004).

Qin, R.

C. Kim, R. Qin, J. S. Xu, L. V. Wang, and R. Xu, J. Biomed. Opt. 15, 010510 (2010).
[CrossRef]

Qin, S.

S. Qin, C. F. Caskey, and K. W. Ferrara, Phys. Med. Biol. 54, R27 (2009).

Raichlen, J.

B. B. Goldberg, J. Raichlen, and F. Forsberg, Ultrasound Contrast Agents: Basic Principles and Clinical Applications, 2nd ed. (Dunitz, 2001).

Sarkar, K.

K. Sarkar, A. Katiyar, and P. Jain, Ultrasound Med. Biol. 35, 1385 (2009).
[CrossRef]

Sijl, J.

M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

Sirsi, S. R.

S. R. Sirsi and M. A. Borden, Theranostics 2, 1208 (2012).

J. A. Feshitan, F. Vlachos, S. R. Sirsi, E. E. Konofagou, and M. A. Borden, Biomaterials 33, 247 (2012).
[CrossRef]

Song, W.

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

Ten Cate, F. J.

P. J. A. Frinking, A. Bouakaz, J. Kirkhorn, F. J. Ten Cate, and N. de Jong, Ultrasound Med. Biol. 26, 965 (2000).
[CrossRef]

Unger, E. C.

E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, Adv. Drug Deliv. Rev. 56, 1291 (2004).

van der Meer, S.

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

van der Meer, S. M.

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

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V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
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S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
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P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
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B. Yuan, Y. Li, P. M. Mehl, and J. Vifnola, Appl. Phys. Lett. 95, 181113 (2009).
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J. A. Feshitan, F. Vlachos, S. R. Sirsi, E. E. Konofagou, and M. A. Borden, Biomaterials 33, 247 (2012).
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S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
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C. Kim, R. Qin, J. S. Xu, L. V. Wang, and R. Xu, J. Biomed. Opt. 15, 010510 (2010).
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F. Yang, Y. Li, Z. Chen, Y. Zhang, J. Wu, and N. Gu, Biomaterials 30, 3882 (2009).
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Appl. Opt.

Appl. Phys. Lett.

V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis, Appl. Phys. Lett. 90, 114103 (2007).
[CrossRef]

B. Yuan, Y. Li, P. M. Mehl, and J. Vifnola, Appl. Phys. Lett. 95, 181113 (2009).
[CrossRef]

Biomaterials

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[CrossRef]

F. Yang, Y. Li, Z. Chen, Y. Zhang, J. Wu, and N. Gu, Biomaterials 30, 3882 (2009).
[CrossRef]

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J. Guan and T. J. Matula, J. Acoust. Soc. Am. 116, 2832 (2004).
[CrossRef]

P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse, J. Acoust. Soc. Am. 118, 3499 (2005).
[CrossRef]

S. M. van der Meer, B. Dollet, M. M. Voormolen, C. T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse, J. Acoust. Soc. Am. 121, 648 (2007).
[CrossRef]

J. Biomed. Opt

M. Jeon, W. Song, E. Huynh, J. Kim, J. Kim, B. L. Helfield, B. Y. C. Leung, D. E. Goertz, G. Zheng, J. Oh, J. Lovell, and C. Kim, J. Biomed. Opt. 19, 016005 (2014).
[CrossRef]

J. Biomed. Opt.

C. Kim, R. Qin, J. S. Xu, L. V. Wang, and R. Xu, J. Biomed. Opt. 15, 010510 (2010).
[CrossRef]

Y. H. Wang, A. H. Liao, J. H. Chen, C. R. C. Wang, and P. C. Li, J. Biomed. Opt. 17, 0450011 (2012).

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C. C. Chen and M. A. Borden, Langmuir 26, 13183 (2010).
[CrossRef]

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M. Overvelde, V. Garbin, J. Sijl, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 36, 2080 (2010).
[CrossRef]

M. Overvelde, V. Garbin, B. Dollet, N. de Jong, D. Lohse, and M. Versluis, Ultrasound Med. Biol. 37, 1500 (2011).
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Figures (4)

Fig. 1.
Fig. 1.

(a) Experimental setup used to excite and detect the gold-coated microbubble oscillations and (b) the calibration curve used to convert the measured optical power at the photodetector to microbubble radius. The shaded area corresponds to a 95% confidence interval. The inset shows the static sensitivity as a function of microbubble radius.

Fig. 2.
Fig. 2.

Time domain responses of gold-coated microbubbles to pulsed laser excitation for different microbubble sizes. The dark field images of the microbubbles are shown above the measured responses.

Fig. 3.
Fig. 3.

Measured eigenfrequencies for 194 gold coated microbubbles as a function of microbubble radius. The solid curve is the theoretical response for a shelled bubble with a shell elasticity of 0.74N/m, while the dashed curve is the theoretical response for a “clean” or unshelled bubble.

Fig. 4.
Fig. 4.

(a) Histogram of the calculated shell elasticity from the measured microbubble responses and (b) maximum radial displacement as a function of inverse microbubble resting radius. The dashed line is a linear fit to the measured response.

Equations (1)

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f0=12π1ρR2(3γP0+2(3γ1)σwR+4χR),

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