Abstract

Multispectral optoacoustic tomography (MSOT) of functional and molecular contrast has the potential to find broad deployment in clinical practice. We have developed the first handheld MSOT imaging device with fast wavelength tuning achieving a frame rate of 50 Hz. In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers.

© 2013 Optical Society of America

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  1. P. Beard, Interface Focus 1, 602 (2011).
    [CrossRef]
  2. A. Dima and V. Ntziachristos, Expert Opin. Med. Diagn. 5, 263 (2011).
    [CrossRef]
  3. A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
    [CrossRef]
  4. A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
    [CrossRef]
  5. D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
    [CrossRef]
  6. G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
    [CrossRef]
  7. A. Taruttis, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Express 18, 19592 (2010).
    [CrossRef]
  8. J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
    [CrossRef]
  9. C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
    [CrossRef]
  10. S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
    [CrossRef]
  11. A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
    [CrossRef]
  12. E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
    [CrossRef]
  13. A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012).
    [CrossRef]
  14. A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Lett. 35, 2475 (2010).
    [CrossRef]
  15. A. Buehler, X. L. Dean-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, Opt. Express 20, 22712 (2012).
    [CrossRef]
  16. M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
    [CrossRef]
  17. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489(2009).
    [CrossRef]
  18. A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
    [CrossRef]
  19. D. Razansky, A. Buehler, and V. Ntziachristos, Nat. Protocols 6, 1121 (2011).
    [CrossRef]
  20. M. H. Xu and L. H. V. Wang, Phys. Rev. E 71, 016706 (2005).
    [CrossRef]
  21. V. Ntziachristos and D. Razansky, Chem. Rev. 110, 2783 (2010).
    [CrossRef]
  22. A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1275 (2010).
    [CrossRef]

2012 (9)

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012).
[CrossRef]

A. Buehler, X. L. Dean-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, Opt. Express 20, 22712 (2012).
[CrossRef]

A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
[CrossRef]

2011 (3)

D. Razansky, A. Buehler, and V. Ntziachristos, Nat. Protocols 6, 1121 (2011).
[CrossRef]

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

A. Dima and V. Ntziachristos, Expert Opin. Med. Diagn. 5, 263 (2011).
[CrossRef]

2010 (6)

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

A. Taruttis, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Express 18, 19592 (2010).
[CrossRef]

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Lett. 35, 2475 (2010).
[CrossRef]

V. Ntziachristos and D. Razansky, Chem. Rev. 110, 2783 (2010).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1275 (2010).
[CrossRef]

2009 (2)

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489(2009).
[CrossRef]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

2007 (1)

S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
[CrossRef]

2005 (1)

M. H. Xu and L. H. V. Wang, Phys. Rev. E 71, 016706 (2005).
[CrossRef]

Aguirre, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489(2009).
[CrossRef]

Aichler, M.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Ale, A.

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

Beard, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

Beziere, N.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

Brecht, H.-P.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Buehler, A.

A. Buehler, X. L. Dean-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, Opt. Express 20, 22712 (2012).
[CrossRef]

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

D. Razansky, A. Buehler, and V. Ntziachristos, Nat. Protocols 6, 1121 (2011).
[CrossRef]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Lett. 35, 2475 (2010).
[CrossRef]

Burton, N. C.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
[CrossRef]

Claussen, J.

A. Buehler, X. L. Dean-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, Opt. Express 20, 22712 (2012).
[CrossRef]

A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
[CrossRef]

Conjusteau, A.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Cox, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

Dean-Ben, X. L.

Dima, A.

A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012).
[CrossRef]

A. Dima and V. Ntziachristos, Expert Opin. Med. Diagn. 5, 263 (2011).
[CrossRef]

Distel, M.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Ermilov, S. A.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Filonov, G. S.

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

Fronheiser, M. P.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Gamelin, J.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489(2009).
[CrossRef]

Guo, P. Y.

Haag, R.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Herzog, E.

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

A. Taruttis, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Express 18, 19592 (2010).
[CrossRef]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Lett. 35, 2475 (2010).
[CrossRef]

Huang, F.

Johnson, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

Koester, R. W.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Kosanke, K.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Krumholz, A.

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

Lao, Y.

S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
[CrossRef]

Laufer, J.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

Li, C.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

Licha, K.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Lutich, A. A.

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

Ma, R.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Maurudis, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489(2009).
[CrossRef]

Mehta, K.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Morscher, S.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
[CrossRef]

Ntziachristos, V.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
[CrossRef]

A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012).
[CrossRef]

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

A. Buehler, X. L. Dean-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, Opt. Express 20, 22712 (2012).
[CrossRef]

A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
[CrossRef]

D. Razansky, A. Buehler, and V. Ntziachristos, Nat. Protocols 6, 1121 (2011).
[CrossRef]

A. Dima and V. Ntziachristos, Expert Opin. Med. Diagn. 5, 263 (2011).
[CrossRef]

A. Taruttis, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Express 18, 19592 (2010).
[CrossRef]

V. Ntziachristos and D. Razansky, Chem. Rev. 110, 2783 (2010).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1275 (2010).
[CrossRef]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Lett. 35, 2475 (2010).
[CrossRef]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Oraevsky, A. A.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Pedley, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

Perrimon, N.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Razansky, D.

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
[CrossRef]

A. Buehler, X. L. Dean-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, Opt. Express 20, 22712 (2012).
[CrossRef]

A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
[CrossRef]

D. Razansky, A. Buehler, and V. Ntziachristos, Nat. Protocols 6, 1121 (2011).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1275 (2010).
[CrossRef]

V. Ntziachristos and D. Razansky, Chem. Rev. 110, 2783 (2010).
[CrossRef]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Lett. 35, 2475 (2010).
[CrossRef]

A. Taruttis, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Express 18, 19592 (2010).
[CrossRef]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Rosenthal, A.

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1275 (2010).
[CrossRef]

Rummeny, E.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Smith, B. D.

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
[CrossRef]

Su, R.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
[CrossRef]

Taruttis, A.

A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
[CrossRef]

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

A. Taruttis, E. Herzog, D. Razansky, and V. Ntziachristos, Opt. Express 18, 19592 (2010).
[CrossRef]

Treeby, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

Verkhusha, V. V.

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

Vinegoni, C.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
[CrossRef]

Walch, A.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Wang, L. H. V.

M. H. Xu and L. H. V. Wang, Phys. Rev. E 71, 016706 (2005).
[CrossRef]

Wang, L. V.

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489(2009).
[CrossRef]

Wildgruber, M.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
[CrossRef]

Xia, J.

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

Xiang, L.

S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
[CrossRef]

Xing, D.

S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
[CrossRef]

Xu, M. H.

M. H. Xu and L. H. V. Wang, Phys. Rev. E 71, 016706 (2005).
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S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
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G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
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Zhang, E.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
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Zhou, Q.

S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
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C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
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Ang. Chem. Int. Ed. (1)

G. S. Filonov, A. Krumholz, J. Xia, J. Yao, L. V. Wang, and V. V. Verkhusha, Ang. Chem. Int. Ed. 51, 1448(2012).
[CrossRef]

Chem. Rev. (1)

V. Ntziachristos and D. Razansky, Chem. Rev. 110, 2783 (2010).
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EJNMMI Res. (1)

A. Buehler, E. Herzog, A. Ale, B. D. Smith, V. Ntziachristos, and D. Razansky, EJNMMI Res. 2, 14 (2012).
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Expert Opin. Med. Diagn. (1)

A. Dima and V. Ntziachristos, Expert Opin. Med. Diagn. 5, 263 (2011).
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IEEE Trans. Med. Imaging (1)

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1275 (2010).
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Interface Focus (1)

P. Beard, Interface Focus 1, 602 (2011).
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J. Biomed. Opt. (4)

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, J. Biomed. Opt. 17, 056016 (2012).
[CrossRef]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. 15, 010509 (2010).
[CrossRef]

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, J. Biomed. Opt. 15, 021305 (2010).
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A. Taruttis, J. Claussen, D. Razansky, and V. Ntziachristos, J. Biomed. Opt. 17, 016009 (2012).
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Med. Phys. (1)

S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, Med. Phys. 34, 3294 (2007).
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D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koester, and V. Ntziachristos, Nat. Photonics 3, 412 (2009).
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Nat. Protocols (1)

D. Razansky, A. Buehler, and V. Ntziachristos, Nat. Protocols 6, 1121 (2011).
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Opt. Express (4)

Opt. Lett. (1)

Photoacoustics (1)

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, Photoacoustics 1, e3 (2012).
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Phys. Rev. E (1)

M. H. Xu and L. H. V. Wang, Phys. Rev. E 71, 016706 (2005).
[CrossRef]

PLoS One (1)

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, PLoS One 7, e30491 (2012).
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Radiology (1)

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, Radiology 263, 461 (2012).
[CrossRef]

Supplementary Material (1)

» Media 1: AVI (708 KB)     

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Figures (3)

Fig. 1.
Fig. 1.

Drawing of the handheld device (a) and photograph of it (b). Simulated sensitivity distribution of the array within the detection band (c) and the wavelength dependency of the laser energy (d). 1, fiber bundle output; 2, transducer array; 3, membrane; 4, illumination pattern; 5, fiber bundle; 6, electrical cables.

Fig. 2.
Fig. 2.

Single-wavelength image of the wrist at 760 nm (a) and 860 nm (b). rv, radial vein; ra, radial artery; s, skin. (c) Profiles through the multispectral dataset from the locations labeled in (b).

Fig. 3.
Fig. 3.

(a)–(d) Unmixed deoxyhemoglobin (Hb) and oxyhemoglobin (HbO2) superimposed onto the total BV image before (first column) and after (second column) release of vascular blocking. (e) Temporal evolution of the extracted properties within the area indicated in (c). The arrows indicate the area at which the deoxyhemoglobin signal changes.

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