Abstract

A wavelength-multiplexing phase-sensitive surface plasmon resonance (SPR) imaging sensor offering wide dynamic detection range and microarray capability is reported. Phase detection is accomplished by performing self-interference between the s- and p- polarizations within the signal beam. A liquid crystal tunable filter is used to sequentially select the SPR excitation wavelength from a white light source. This wavelength-multiplexing approach enables fast detection of the sensor’s SPR phase response over a wide range of wavelengths, thereby covering literally any regions of interest within the SPR dip and thus maintaining the highest sensitivity point at all times. The phase-sensitive approach is particularly important for imaging SPR sensing applications because of its less stringent requirements for intensity signal-to-noise ratio, which also means the possibility of using uncooled modest resolution analog-to-digital conversion imaging devices. Experimental results demonstrate a resolution of 2.7×107RIU with a dynamic range of 0.0138 RIU.

© 2013 Optical Society of America

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References

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2012 (1)

Y.-R. Liang, H.-Z. Duan, H.-C. Yeh, and J. Luo, Rev. Sci. Instrum. 83, 095110 (2012).
[CrossRef]

2011 (2)

2009 (1)

2008 (2)

Y.-C. Li, Y.-F. Chang, L.-C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef]

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

2007 (1)

2005 (1)

H. P. Ho, W. C. Law, S. Y. Wu, C. Lin, and S. K. Kong, Biosens. Bioelectron. 20, 2177 (2005).
[CrossRef]

2003 (1)

M. Palumbo, C. Pearson, J. Nagel, and M. C. Petty, Sens. Actuators B 90, 264 (2003).
[CrossRef]

1999 (1)

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

1993 (1)

B. Liedberg, I. Lundstrom, and E. Stenberg, Sens. Actuators B 11, 63 (1993).
[CrossRef]

Besselink, G. A. J.

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

Beusink, J. B.

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

Chang, Y.-F.

Y.-C. Li, Y.-F. Chang, L.-C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef]

Chou, C.

Y.-C. Li, Y.-F. Chang, L.-C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef]

Chow, W. W. Y.

Duan, H.-Z.

Y.-R. Liang, H.-Z. Duan, H.-C. Yeh, and J. Luo, Rev. Sci. Instrum. 83, 095110 (2012).
[CrossRef]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Grigorenko, A. N.

Ho, H. P.

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Huang, Y. H.

Kabashin, A. V.

Kong, S. K.

Law, W. C.

Li, W. J.

Li, Y.-C.

Y.-C. Li, Y.-F. Chang, L.-C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef]

Liang, Y.-R.

Y.-R. Liang, H.-Z. Duan, H.-C. Yeh, and J. Luo, Rev. Sci. Instrum. 83, 095110 (2012).
[CrossRef]

Liedberg, B.

B. Liedberg, I. Lundstrom, and E. Stenberg, Sens. Actuators B 11, 63 (1993).
[CrossRef]

Lin, C.

Lokate, A. M. C.

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

Lundstrom, I.

B. Liedberg, I. Lundstrom, and E. Stenberg, Sens. Actuators B 11, 63 (1993).
[CrossRef]

Luo, J.

Y.-R. Liang, H.-Z. Duan, H.-C. Yeh, and J. Luo, Rev. Sci. Instrum. 83, 095110 (2012).
[CrossRef]

Nagel, J.

M. Palumbo, C. Pearson, J. Nagel, and M. C. Petty, Sens. Actuators B 90, 264 (2003).
[CrossRef]

Ng, S. P.

Palumbo, M.

M. Palumbo, C. Pearson, J. Nagel, and M. C. Petty, Sens. Actuators B 90, 264 (2003).
[CrossRef]

Patskovsky, S.

Pearson, C.

M. Palumbo, C. Pearson, J. Nagel, and M. C. Petty, Sens. Actuators B 90, 264 (2003).
[CrossRef]

Petty, M. C.

M. Palumbo, C. Pearson, J. Nagel, and M. C. Petty, Sens. Actuators B 90, 264 (2003).
[CrossRef]

Pruijn, G. J. M.

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

Schasfoort, R. B. M.

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

Shum, P.

Stenberg, E.

B. Liedberg, I. Lundstrom, and E. Stenberg, Sens. Actuators B 11, 63 (1993).
[CrossRef]

Su, L.-C.

Y.-C. Li, Y.-F. Chang, L.-C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef]

Suen, Y. K.

Wong, C. L.

Wong, W. W.

Wu, C. M. L.

Wu, S. Y.

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Yeh, H.-C.

Y.-R. Liang, H.-Z. Duan, H.-C. Yeh, and J. Luo, Rev. Sci. Instrum. 83, 095110 (2012).
[CrossRef]

Yu, T. T.

Yuan, W.

Anal. Chem. (1)

Y.-C. Li, Y.-F. Chang, L.-C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef]

Appl. Opt. (1)

Biosens. Bioelectron. (2)

H. P. Ho, W. C. Law, S. Y. Wu, C. Lin, and S. K. Kong, Biosens. Bioelectron. 20, 2177 (2005).
[CrossRef]

J. B. Beusink, A. M. C. Lokate, G. A. J. Besselink, G. J. M. Pruijn, and R. B. M. Schasfoort, Biosens. Bioelectron. 23, 839 (2008).
[CrossRef]

Opt. Express (2)

Opt. Lett. (1)

Rev. Sci. Instrum. (1)

Y.-R. Liang, H.-Z. Duan, H.-C. Yeh, and J. Luo, Rev. Sci. Instrum. 83, 095110 (2012).
[CrossRef]

Sens. Actuators B (3)

M. Palumbo, C. Pearson, J. Nagel, and M. C. Petty, Sens. Actuators B 90, 264 (2003).
[CrossRef]

B. Liedberg, I. Lundstrom, and E. Stenberg, Sens. Actuators B 11, 63 (1993).
[CrossRef]

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

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Figures (4)

Fig. 1.
Fig. 1.

Schematic of our WM-pSPRi system. L1, L2, L3, L4, and L5, lens; MF, multimode fiber; LCTF, liquid crystal tunable filter; LCM, liquid crystal modulator.

Fig. 2.
Fig. 2.

Phase response versus wavelength for glycerin-water samples with concentration level ranging from 0% to 18%.

Fig. 3.
Fig. 3.

Phase response versus PBS buffer concentration in water.

Fig. 4.
Fig. 4.

Real-time phase response of antigen–antibody binding reaction. Human IgG with goat antihuman IgG (black curve), rabbit antihuman IgG with goat antirabbit IgG (red curve).

Equations (1)

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σRI=δnδY·σSD,

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