Abstract

By detecting ultrasonically tagged diffuse light, ultrasound-modulated optical tomography images optical contrast with ultrasonic resolution deep in turbid media, such as biological tissue. However, small detection etendues and weak tagged light submerged in strong untagged background light limit the signal detection sensitivity. In this Letter, we report the use of a large-area (5cm×5cm) photorefractive polymer film that yields more than 10 times detection etendue over previous detection schemes. Our polymer-based system enabled us to resolve absorbing objects embedded inside diffused media thicker than 80 transport mean free paths, by using moderate light power and short ultrasound pulses.

© 2013 Optical Society of America

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2012 (3)

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

Y. Suzuki, X. Xu, P. Lai, and L. V. Wang, J. Biomed. Opt. 17, 080507 (2012).
[CrossRef]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[CrossRef]

2010 (1)

2009 (2)

2008 (3)

G. Rousseau, A. Blouin, and J.-P. Monchalin, Opt. Express 16, 12577 (2008).
[CrossRef]

Y. Li, P. Hemmer, C. Kim, H. Zhang, and L. V. Wang, Opt. Express 16, 14862 (2008).
[CrossRef]

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

2007 (1)

2006 (1)

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

2005 (1)

2004 (3)

1999 (1)

1997 (1)

1995 (1)

Atlan, M.

Blanche, P. A.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Blonigen, F. J.

Blouin, A.

Boccara, A. C.

Dimarzio, C. A.

Eralp, M.

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Farahi, S.

Flores, D.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Forget, B. C.

Genack, A. Z.

Grabar, A. A.

Gu, T.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Hemmer, P.

Hemmer, P. R.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

Hilaire, P. St

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Huignard, J. P.

Jacques, S. L.

Kempe, M.

Kim, C.

Kroll, S.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

Lai, P.

Y. Suzuki, X. Xu, P. Lai, and L. V. Wang, J. Biomed. Opt. 17, 080507 (2012).
[CrossRef]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[CrossRef]

P. Lai, R. A. Roy, and T. W. Murray, Opt. Lett. 34, 2850 (2009).
[CrossRef]

Larionov, M.

Lebec, M.

Leveqe-Fort, S.

Li, G.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Li, Y.

Lin, W.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Maguluri, G.

Monchalin, J.-P.

Montemezzani, G.

Murray, T. W.

Nieva, A.

Norwood, R.

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Norwood, R. A.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Peyghambarian, N.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Qing, D.-k.

Ramaz, F.

Rippe, L.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

Rokutanda, S.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Rousseau, G.

Roy, R. A.

Sabooni, M.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

Saint-Jalmes, H.

Sakadzic, S.

Schulzgen, A.

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Sui, L.

Suzuki, Y.

Y. Suzuki, X. Xu, P. Lai, and L. V. Wang, J. Biomed. Opt. 17, 080507 (2012).
[CrossRef]

Tay, S.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Thomas, J.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Tunc, A. V.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Voorakaranam, R.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Wang, L. V.

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[CrossRef]

Y. Suzuki, X. Xu, P. Lai, and L. V. Wang, J. Biomed. Opt. 17, 080507 (2012).
[CrossRef]

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

Y. Li, P. Hemmer, C. Kim, H. Zhang, and L. V. Wang, Opt. Express 16, 14862 (2008).
[CrossRef]

X. Xu, H. Zhang, P. Hemmer, D.-k. Qing, C. Kim, and L. V. Wang, Opt. Lett. 32, 656 (2007).
[CrossRef]

S. Sakadzic and L. V. Wang, Opt. Lett. 29, 2770 (2004).
[CrossRef]

L. V. Wang, S. L. Jacques, and X. Zhao, Opt. Lett. 20, 629 (1995).
[CrossRef]

Wang, P.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Xu, X.

Y. Suzuki, X. Xu, P. Lai, and L. V. Wang, J. Biomed. Opt. 17, 080507 (2012).
[CrossRef]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[CrossRef]

X. Xu, H. Zhang, P. Hemmer, D.-k. Qing, C. Kim, and L. V. Wang, Opt. Lett. 32, 656 (2007).
[CrossRef]

Yamamoto, M.

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

Zaslavsky, D.

Zhang, H.

Zhao, X.

Appl. Opt. (1)

Appl. Phys. Lett. (1)

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kroll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[CrossRef]

J. Biomed. Opt. (2)

Y. Suzuki, X. Xu, P. Lai, and L. V. Wang, J. Biomed. Opt. 17, 080507 (2012).
[CrossRef]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[CrossRef]

J. Opt. Soc. Am. A (1)

Nature (1)

S. Tay, P. A. Blanche, R. Voorakaranam, A. V. Tunc, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto, and N. Peyghambarian, Nature 451, 694 (2008).
[CrossRef]

Opt. Express (3)

Opt. Lett. (8)

Proc. SPIE (1)

J. Thomas, M. Eralp, S. Tay, G. Li, P. Wang, M. Yamamoto, A. Schulzgen, R. Norwood, and N. Peyghambarian, Proc. SPIE 6335, 633503 (2006).
[CrossRef]

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Figures (4)

Fig. 1.
Fig. 1.

(a) Experimental setup used for the study. BB, beam block; BE1,2, beam expanders; HWP, half-wave plate; L1,2, lenses; PD, photodiode; PRP, photorefractive polymer film; R, reference beam; S0 and S, incident and collected sample beams, respectively; UT, ultrasound transducer; VBS, variable beam splitter, composed of a half-wave plate and a polarizing beam splitter; XYZ, system coordinates. (b) Illustration of beam interference with respect to the PRP in top view.

Fig. 2.
Fig. 2.

(a) Comparison of etendue. Each column corresponds to one case reported from the references detailed in the text. (b) Comparison of sample beam amplifications.

Fig. 3.
Fig. 3.

(a) Photograph of the mid-plane of sample 1. (b) 2D UOT image of the sample’s mid-plane. (c), (d) Signal profiles along the horizontal and vertical dashed lines in (b), respectively.

Fig. 4.
Fig. 4.

(a) Photograph of the mid-plane of sample 2. (b) 2D UOT image of the sample’s mid-plane.

Tables (1)

Tables Icon

Table 1. Key Parameters of the System

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