Abstract

Despite the challenges in achieving high phase stability, Doppler swept-source/Fourier-domain optical coherence tomography (OCT) has advantages of less fringe washout and faster imaging speeds compared to spectral/Fourier-domain detection. This Letter demonstrates swept-source OCT with a vertical cavity surface-emitting laser light source at 400 kHz sweep rate for phase-sensitive Doppler imaging, measuring pulsatile total retinal blood flow with high sensitivity and phase stability. A robust, simple, and computationally efficient phase stabilization approach for phase-sensitive swept-source imaging is also presented.

© 2013 Optical Society of America

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2012 (3)

2011 (3)

2010 (1)

2008 (1)

2005 (2)

2004 (1)

2003 (1)

Bajraszewski, T.

Baumann, B.

Boas, D. A.

Bouma, B. E.

Braaf, B.

Burgner, C.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

Cable, A.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, Opt. Express 16, 15149 (2008).
[CrossRef]

Cable, A. E.

Cense, B.

Chen, Y. L.

Choi, W.

Clermont, A. C.

Cole, G. D.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

de Boer, J. F.

Dhalla, A.-H.

Drexler, W.

Duker, J. S.

Feener, E. P.

Fercher, A. F.

Fujimoto, J. G.

Gorczynska, I.

Grulkowski, I.

Hendargo, H. C.

Hornegger, J.

Huang, D.

Izatt, J. A.

Jayaraman, V.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, Biomed. Opt. Express 3, 2733 (2012).
[CrossRef]

Jiang, J.

John, D.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

Kraus, M. F.

Leitgeb, R. A.

Liu, J. J.

Lu, C. D.

McNabb, R. P.

Mujat, M.

Park, B. H.

Pierce, M. C.

Potsaid, B.

Robertson, M.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

Ruvinskaya, S.

Sakadzic, S.

Schmetterer, L.

Shepherd, N.

Sicam, V. A. D. P.

Srinivasan, V. J.

Tearney, G. J.

Uddin, A.

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

Vakoc, B. J.

van Meurs, J. C.

van Zeeburg, E.

Vermeer, K. A.

Wu, W. C.

Yun, S. H.

Zawadzki, R. J.

Biomed. Opt. Express (4)

Electron. Lett. (1)

V. Jayaraman, G. D. Cole, M. Robertson, C. Burgner, D. John, A. Uddin, and A. Cable, Electron. Lett. 48, 1331 (2012).
[CrossRef]

Opt. Express (7)

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Figures (3)

Fig. 1.
Fig. 1.

(A) Schematic of swept-source OCT system. (B) MZI is used for optical clocking. SOA, semiconductor optical amplifier; PC, polarization controller; FBG, fiber Bragg grating. (C), (D) FBG traces in the OCT interferogram before and after numerical trigger jitter correction.

Fig. 2.
Fig. 2.

(A), (B) OCT images of optic nerve head before and after the numerical trigger jitter correction. 3000 A-scans over 3 mm. (C), (D) OCT Doppler images of the optic nerve head before and after the numerical trigger jitter correction. 3000 A-scans over 3 mm. (E) Typical OCT B-scan consisting of 500 A-scans over 12 mm. All scale bars: 1 mm.

Fig. 3.
Fig. 3.

(A) Time-resolved pulsatile total arterial blood flow. (B) An en face intensity projection image. 1.5mm×1.5mm. (C)–(F) En face Doppler images at different time points indicated by the black arrows in (A). 1.5mm×1.5mm. All scale bars: 500 μm.

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