The controlled navigation of the axonal growth cone of a neuron toward the dendrite of its synaptic partner neuron is the fundamental process in forming neuronal circuitry. While a number of technologies have been pursued for axonal guidance over the past decades, they are either invasive or not controllable with high spatial and temporal resolution and are often limited by low guidance efficacy. Here, we report a neuronal beacon based on light for highly efficient and controlled guidance of cortical primary neurons.
© 2013 Optical Society of AmericaFull Article | PDF Article
Samarendra K. Mohanty, Mrinalini Sharma, Mitradas M. Panicker, and Pradeep K. Gupta
Opt. Lett. 30(19) 2596-2598 (2005)
D. J. Stevenson, T. K. Lake, B. Agate, V. Garcés-Chávez, K. Dholakia, and F. Gunn-Moore
Opt. Express 14(21) 9786-9793 (2006)
G. Nageswara Rao, Sucheta S. Kulkarni, Sandhya P. Koushika, and Kaustubh R. Rau
Opt. Express 16(13) 9884-9894 (2008)