Abstract

We demonstrate a cross-phase modulation measurement technique based on the sensitive detection of modulation transfer in a pump-probe setup. By modulating the amplitude of the pump beam and spectrally analyzing the probe beam, we achieve a rapid, background-free measurement of nonlinear phase modulation using power levels acceptable in biological imaging. This measurement technique would allow the extension of widely employed phase microscopy methods to the nonlinear regime, providing intrinsic and universal nonlinear contrast for biological imaging.

© 2012 Optical Society of America

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2011

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 3, 71 (2011).

2010

2008

2007

D. Fu, T. Ye, T. E. Matthews, G. Yurtsever, and W. S. Warren, J. Biomed. Opt. 12, 054004 (2007).
[CrossRef]

2005

1997

P. B. Chapple, J. Staromlynska, J. A. Hermann, T. J. McKay, and R. G. McDuff, J. Nonlinear Opt. Phys. 6, 251 (1997).
[CrossRef]

1995

1994

1989

Chapple, P. B.

P. B. Chapple, J. Staromlynska, J. A. Hermann, T. J. McKay, and R. G. McDuff, J. Nonlinear Opt. Phys. 6, 251 (1997).
[CrossRef]

Ciocca, M.

Escobedo-Lozoya, Y.

Fischer, M. C.

Fu, D.

D. Fu, T. Ye, T. E. Matthews, J. Grichnik, L. Hong, J. D. Simon, and W. S. Warren, J. Biomed. Opt. 13, 054036 (2008).
[CrossRef]

D. Fu, T. Ye, T. E. Matthews, G. Yurtsever, and W. S. Warren, J. Biomed. Opt. 12, 054004 (2007).
[CrossRef]

Goswami, D.

Grichnik, J.

D. Fu, T. Ye, T. E. Matthews, J. Grichnik, L. Hong, J. D. Simon, and W. S. Warren, J. Biomed. Opt. 13, 054036 (2008).
[CrossRef]

Hermann, J. A.

P. B. Chapple, J. Staromlynska, J. A. Hermann, T. J. McKay, and R. G. McDuff, J. Nonlinear Opt. Phys. 6, 251 (1997).
[CrossRef]

Hillegas, C. W.

Hong, L.

D. Fu, T. Ye, T. E. Matthews, J. Grichnik, L. Hong, J. D. Simon, and W. S. Warren, J. Biomed. Opt. 13, 054036 (2008).
[CrossRef]

Liu, H. C.

Matthews, T. E.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 3, 71 (2011).

D. Fu, T. Ye, T. E. Matthews, J. Grichnik, L. Hong, J. D. Simon, and W. S. Warren, J. Biomed. Opt. 13, 054036 (2008).
[CrossRef]

D. Fu, T. Ye, T. E. Matthews, G. Yurtsever, and W. S. Warren, J. Biomed. Opt. 12, 054004 (2007).
[CrossRef]

McDuff, R. G.

P. B. Chapple, J. Staromlynska, J. A. Hermann, T. J. McKay, and R. G. McDuff, J. Nonlinear Opt. Phys. 6, 251 (1997).
[CrossRef]

McKay, T. J.

P. B. Chapple, J. Staromlynska, J. A. Hermann, T. J. McKay, and R. G. McDuff, J. Nonlinear Opt. Phys. 6, 251 (1997).
[CrossRef]

Miller, A.

Perret, Z.

Piletic, I. R.

Said, A. A.

Samineni, P.

Selim, M. A.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 3, 71 (2011).

Sheik-Bahae, M.

Shore, K. A.

Simon, J. D.

D. Fu, T. Ye, T. E. Matthews, J. Grichnik, L. Hong, J. D. Simon, and W. S. Warren, J. Biomed. Opt. 13, 054036 (2008).
[CrossRef]

Simpson, M. J.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 3, 71 (2011).

Spencer, P. S.

Staromlynska, J.

P. B. Chapple, J. Staromlynska, J. A. Hermann, T. J. McKay, and R. G. McDuff, J. Nonlinear Opt. Phys. 6, 251 (1997).
[CrossRef]

Strickland, D.

Tull, J. X.

Van Stryland, E. W.

Wagner, W.

Warren, W. S.

Yasuda, R.

Ye, T.

D. Fu, T. Ye, T. E. Matthews, J. Grichnik, L. Hong, J. D. Simon, and W. S. Warren, J. Biomed. Opt. 13, 054036 (2008).
[CrossRef]

D. Fu, T. Ye, T. E. Matthews, G. Yurtsever, and W. S. Warren, J. Biomed. Opt. 12, 054004 (2007).
[CrossRef]

M. C. Fischer, T. Ye, G. Yurtsever, A. Miller, M. Ciocca, W. Wagner, and W. S. Warren, Opt. Lett. 30, 1551 (2005).
[CrossRef]

Yurtsever, G.

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