Abstract

Optical-resolution photoacoustic microscopy is becoming a powerful research tool for studying microcirculation in vivo. Moreover, ultrasonic-array-based optical-resolution photoacoustic computed tomography (OR-PACT), providing comparable resolution at an improved speed, has opened up new opportunities for studying microvascular dynamics. In this Letter, we have developed a compressed sensing with partially known support (CS-PKS) photoacoustic reconstruction strategy for OR-PACT. Compared with conventional backprojection reconstruction, the CS-PKS strategy was shown to produce high-quality in vivo OR-PACT images with threefold less measurement data, which can be leveraged to improve the data acquisition speed and costs of OR-PACT systems.

© 2012 Optical Society of America

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2012 (2)

2011 (1)

2010 (2)

Z. Guo, C. Li, L. Song, and L. V. Wang, J. Biomed. Opt. 15, 021311 (2010).
[CrossRef]

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

2009 (1)

J. Provost and F. Lesage, IEEE Trans. Med. Imaging 28, 585 (2009).
[CrossRef]

2008 (3)

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

G. H. Chen, J. Tang, and S. Leng, Med. Phys. 35, 660 (2008).
[CrossRef]

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, Opt. Lett. 33, 929 (2008).
[CrossRef]

2007 (1)

M. Lustig, D. Donoho, and J. M. Pauly, Magn. Reson. Med. 58, 1182 (2007).
[CrossRef]

Carson, J. J. L.

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

Chen, G. H.

G. H. Chen, J. Tang, and S. Leng, Med. Phys. 35, 660 (2008).
[CrossRef]

Donoho, D.

M. Lustig, D. Donoho, and J. M. Pauly, Magn. Reson. Med. 58, 1182 (2007).
[CrossRef]

Ephrat, P.

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

Feng, J.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Guo, Z.

Z. Guo, C. Li, L. Song, and L. V. Wang, J. Biomed. Opt. 15, 021311 (2010).
[CrossRef]

Han, D.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Hu, S.

Keenliside, L.

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

Leng, S.

G. H. Chen, J. Tang, and S. Leng, Med. Phys. 35, 660 (2008).
[CrossRef]

Lesage, F.

J. Provost and F. Lesage, IEEE Trans. Med. Imaging 28, 585 (2009).
[CrossRef]

Li, C.

Z. Guo, C. Li, L. Song, and L. V. Wang, J. Biomed. Opt. 15, 021311 (2010).
[CrossRef]

Liang, D.

Liu, K.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Lustig, M.

M. Lustig, D. Donoho, and J. M. Pauly, Magn. Reson. Med. 58, 1182 (2007).
[CrossRef]

Ma, X.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Maslov, K.

Meng, J.

Pauly, J. M.

M. Lustig, D. Donoho, and J. M. Pauly, Magn. Reson. Med. 58, 1182 (2007).
[CrossRef]

Prato, F. S.

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

Provost, J.

J. Provost and F. Lesage, IEEE Trans. Med. Imaging 28, 585 (2009).
[CrossRef]

Qin, C.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Seabrook, A.

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

Song, L.

Tang, J.

G. H. Chen, J. Tang, and S. Leng, Med. Phys. 35, 660 (2008).
[CrossRef]

Tian, J.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Wang, L. V.

Ying, L.

Zhang, B.

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

Zhang, H. F.

IEEE Trans. Biomed. Eng. (1)

D. Han, J. Tian, K. Liu, J. Feng, B. Zhang, X. Ma, and C. Qin, IEEE Trans. Biomed. Eng. 57, 2564 (2010).
[CrossRef]

IEEE Trans. Med. Imaging (1)

J. Provost and F. Lesage, IEEE Trans. Med. Imaging 28, 585 (2009).
[CrossRef]

J. Biomed. Opt. (2)

Z. Guo, C. Li, L. Song, and L. V. Wang, J. Biomed. Opt. 15, 021311 (2010).
[CrossRef]

P. Ephrat, L. Keenliside, A. Seabrook, F. S. Prato, and J. J. L. Carson, J. Biomed. Opt. 13, 054052 (2008).
[CrossRef]

Magn. Reson. Med. (1)

M. Lustig, D. Donoho, and J. M. Pauly, Magn. Reson. Med. 58, 1182 (2007).
[CrossRef]

Med. Phys. (1)

G. H. Chen, J. Tang, and S. Leng, Med. Phys. 35, 660 (2008).
[CrossRef]

Opt. Express (1)

Opt. Lett. (2)

Science (1)

L. V. Wang and S. Hu, Science 335, 1458 (2012).
[CrossRef]

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Figures (4)

Fig. 1.
Fig. 1.

Schematic illustration of OR-PACT.

Fig. 2.
Fig. 2.

Flowchart of our reconstruction strategy for OR-PACT. K, number of B-scans; M, the number of times of optical illumination (25 in this Letter) for each B-scan; PA, photoacoustic; MAP, maximum amplitude projection.

Fig. 3.
Fig. 3.

In vivo OR-PACT images of a mouse ear microvasculature. (A), (B) MAP images reconstructed by BP with data from 48 and 16 transducer elements, respectively. (C) MAP image reconstructed by CS-PKS with data from 16 transducer elements. (a), (b), (c) Selected regions from (A), (B), (C), respectively, as indicated by the rectangular boxes. The number 48 or 16 after each reconstruction method indicates that the reconstruction is performed with data from either 48 or 16 transducer elements. The color scale represents relative optical absorption.

Fig. 4.
Fig. 4.

(A), (B) Histograms of the amplitudes of the difference images using the image reconstructed by BP with data from all 48 transducer elements as the control. (C) Photoacoustic amplitudes along the chosen yellow lines in the MAP images of Figs. 3(A)3(C). (Inset) CNRs of selected signal peaks. The number 48 or 16 after each reconstruction method indicates that the reconstruction is performed with data from either 48 or 16 transducer elements.

Equations (1)

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argminxF=Φxy22+αxΔ1+βTV(Ψ1x),

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