Abstract

Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal target-conjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.

© 2012 Optical Society of America

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2012 (1)

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

2011 (1)

2010 (1)

2008 (2)

F. Vollmer and S. Arnold, Nat. Methods 5, 591 (2008).
[CrossRef]

I. E. Sendroiu and R. M. Corn, Biointerphases 3, FD23 (2008).
[CrossRef]

2007 (3)

S. W. Thomas, G. D. Joly, and T. M. Swager, Chem. Rev. 107, 1339 (2007).
[CrossRef]

D. Crouse and P. Keshavareddy, Opt. Express 15, 1415 (2007).
[CrossRef]

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

2006 (3)

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

S. H. Kim, J.-D. Park, and K.-D. Lee, Nanotechnology 17, 4436 (2006).
[CrossRef]

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

2005 (1)

2003 (2)

1997 (1)

Adamson, D. H.

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[CrossRef]

Arnold, S.

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[CrossRef]

S. Arnold, E. Gardner, D. Hansen, and R. Perkins, in SID 01 Digest (Society for Information Display, 2001), p. 1282.

Asakawa, K.

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

Baac, H.

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

Buonanno, M.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Chaikin, P. M.

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

Chen, L.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Corn, R. M.

I. E. Sendroiu and R. M. Corn, Biointerphases 3, FD23 (2008).
[CrossRef]

Crouse, D.

Deng, X.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Doumuki, T.

Einishi, T.

Fukumi, K.

Gardner, E.

S. Arnold, E. Gardner, D. Hansen, and R. Perkins, in SID 01 Digest (Society for Information Display, 2001), p. 1282.

Hajos, J. P.

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

Hansen, D.

S. Arnold, E. Gardner, D. Hansen, and R. Perkins, in SID 01 Digest (Society for Information Display, 2001), p. 1282.

Horváth, R.

Joly, G. D.

S. W. Thomas, G. D. Joly, and T. M. Swager, Chem. Rev. 107, 1339 (2007).
[CrossRef]

Keshavareddy, P.

Kim, D.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

D. Kim, Appl. Opt. 44, 1366 (2005).
[CrossRef]

D. Kim, C. Warde, K. Vaccaro, and C. Woods, Appl. Opt. 42, 3756 (2003).
[CrossRef]

Kim, H. C.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Kim, S. H.

S. H. Kim, J.-D. Park, and K.-D. Lee, Nanotechnology 17, 4436 (2006).
[CrossRef]

Kim, S. J.

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

Kim, Y.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Koppa, P.

Larsen, N. B.

Lee, H.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Lee, J.

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

Lee, K.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Lee, K.-D.

S. H. Kim, J.-D. Park, and K.-D. Lee, Nanotechnology 17, 4436 (2006).
[CrossRef]

Liu, X.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Matsumoto, S.

Moon, S.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Nishii, J.

Oh, Y.

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Park, J.-D.

S. H. Kim, J.-D. Park, and K.-D. Lee, Nanotechnology 17, 4436 (2006).
[CrossRef]

Pedersen, H. C.

Pelletier, V.

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

Perkins, R.

S. Arnold, E. Gardner, D. Hansen, and R. Perkins, in SID 01 Digest (Society for Information Display, 2001), p. 1282.

Register, R. A.

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

Saito, M.

Selmeczi, D.

Sendroiu, I. E.

I. E. Sendroiu and R. M. Corn, Biointerphases 3, FD23 (2008).
[CrossRef]

Sepsi, Ö.

Shuler, M. L.

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

Skivesen, N.

Swager, T. M.

S. W. Thomas, G. D. Joly, and T. M. Swager, Chem. Rev. 107, 1339 (2007).
[CrossRef]

Szanda, I.

Tai, S.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Tamada, H.

Tani, K.

Thomas, S. W.

S. W. Thomas, G. D. Joly, and T. M. Swager, Chem. Rev. 107, 1339 (2007).
[CrossRef]

Vaccaro, K.

Vollmer, F.

F. Vollmer and S. Arnold, Nat. Methods 5, 591 (2008).
[CrossRef]

Walters, F.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Wang, J. J.

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Warde, C.

Woods, C.

Wu, M.

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

Yamada, I.

Yamaguchi, T.

Yamashita, N.

Appl. Opt. (2)

Appl. Phys. Lett. (2)

V. Pelletier, K. Asakawa, M. Wu, D. H. Adamson, R. A. Register, and P. M. Chaikin, Appl. Phys. Lett. 88, 211114 (2006).
[CrossRef]

L. Chen, J. J. Wang, F. Walters, X. Deng, M. Buonanno, S. Tai, and X. Liu, Appl. Phys. Lett. 90, 063111 (2007).
[CrossRef]

Biointerphases (1)

I. E. Sendroiu and R. M. Corn, Biointerphases 3, FD23 (2008).
[CrossRef]

Biosens. Bioelectron. (1)

S. Moon, Y. Kim, Y. Oh, H. Lee, H. C. Kim, K. Lee, and D. Kim, Biosens. Bioelectron. 32, 141 (2012).
[CrossRef]

Biotechnol. Bioeng. (1)

H. Baac, J. P. Hajos, J. Lee, D. Kim, S. J. Kim, and M. L. Shuler, Biotechnol. Bioeng. 94, 815 (2006).
[CrossRef]

Chem. Rev. (1)

S. W. Thomas, G. D. Joly, and T. M. Swager, Chem. Rev. 107, 1339 (2007).
[CrossRef]

Nanotechnology (1)

S. H. Kim, J.-D. Park, and K.-D. Lee, Nanotechnology 17, 4436 (2006).
[CrossRef]

Nat. Methods (1)

F. Vollmer and S. Arnold, Nat. Methods 5, 591 (2008).
[CrossRef]

Opt. Express (2)

Opt. Lett. (3)

Other (1)

S. Arnold, E. Gardner, D. Hansen, and R. Perkins, in SID 01 Digest (Society for Information Display, 2001), p. 1282.

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Figures (4)

Fig. 1.
Fig. 1.

(a) Schematics of NP-WGP fabrication. (b) SEM image of a final NP-WGP sample (Λ=400nm).

Fig. 2.
Fig. 2.

(a) DNA hybridization dynamics with time for various T-ssDNA concentrations. (b) ER at saturation for different target concentration and fitted to a sigmoidal statistic.

Fig. 3.
Fig. 3.

Measured depolarization during the NP-WGP-mediated DNA hybridization with T-ssDNA concentration.

Fig. 4.
Fig. 4.

Relative ERs assuming that GNPs form perfect WGPs at f=50% in reference to the result of Λ=400nm. Wire-grid thickness (dw) represents the diameter of GNPs.

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