Abstract

We developed pulsed magneto-motive optical coherence tomography (PMM-OCT) to reduce environmental temperature in the measurement volume and to expand the effective magnetic field distance from a pulse source. The proposed PMM-OCT system consisted of a spectral-domain OCT system and a customarily designed electrical pulse generator. The enhanced magnetic field allowed the proposed system to be able to image magnetically labeled cells in a distance as far as 30 mm away from the pulse generator. As an easy and sensitive approach, our PMM-OCT may be beneficially applied to a molecular-level imaging systems.

© 2012 Optical Society of America

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  1. R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
    [CrossRef]
  2. J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
    [CrossRef]
  3. A. Oldenburg, F. Toublan, K. Suslick, A. Wei, and S. Boppart, Opt. Express 13, 6597 (2005).
    [CrossRef]
  4. A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, Opt. Lett. 30, 747 (2005).
    [CrossRef]
  5. J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
    [CrossRef]
  6. H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
    [CrossRef]
  7. M. Jeon, J. Kim, U. Jung, C. Lee, W. Jung, and S. A. Boppart, Appl. Opt. 50, 1158 (2011).
    [CrossRef]
  8. M. H. Niemz, Laser-Tissue Interactions: Fundamentals and Applications (Springer Verlag, 2007).
  9. J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
    [CrossRef]
  10. A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
    [CrossRef]

2012 (1)

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

2011 (1)

2010 (2)

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

2007 (2)

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
[CrossRef]

2006 (1)

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

2005 (2)

Adie, S. G.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Boppart, S.

Boppart, S. A.

M. Jeon, J. Kim, U. Jung, C. Lee, W. Jung, and S. A. Boppart, Appl. Opt. 50, 1158 (2011).
[CrossRef]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, Opt. Lett. 30, 747 (2005).
[CrossRef]

Büchner, B.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Chaney, E. J.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Cho, N. H.

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

Condit, C.

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Emelianov, S.

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Feldman, M. D.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Füssel, S.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Gunther, J. R.

Haldar, J. P.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Jeon, M.

Jeong, H.

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

John, R.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Jung, U.

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

M. Jeon, J. Kim, U. Jung, C. Lee, W. Jung, and S. A. Boppart, Appl. Opt. 50, 1158 (2011).
[CrossRef]

Jung, W.

Kang, H. W.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

Kim, J.

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

M. Jeon, J. Kim, U. Jung, C. Lee, W. Jung, and S. A. Boppart, Appl. Opt. 50, 1158 (2011).
[CrossRef]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Kim, J. Y.

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

Klingeler, R.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Krämer, K.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Krupskaya, Y.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Lee, C.

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

M. Jeon, J. Kim, U. Jung, C. Lee, W. Jung, and S. A. Boppart, Appl. Opt. 50, 1158 (2011).
[CrossRef]

Marjanovic, M.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Milner, T. E.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Nelson, J. S.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
[CrossRef]

Niemz, M. H.

M. H. Niemz, Laser-Tissue Interactions: Fundamentals and Applications (Springer Verlag, 2007).

Oh, J.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Oldenburg, A.

Oldenburg, A. L.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, Opt. Lett. 30, 747 (2005).
[CrossRef]

Rezaeipoor, R.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Sanghi, P.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

Suslick, K.

Sutton, B. P.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Taylor, A.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Toublan, F.

Wei, A.

Wirth, M. P.

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Appl. Opt. (1)

Carbon (1)

A. Taylor, Y. Krupskaya, K. Krämer, S. Füssel, R. Klingeler, B. Büchner, and M. P. Wirth, Carbon 48, 2327 (2010).
[CrossRef]

Lasers Surg. Med. (1)

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, Lasers Surg. Med. 39, 266 (2007).
[CrossRef]

Nanotechnology (2)

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, Nanotechnology 18, 035504 (2007).
[CrossRef]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, Nanotechnology 17, 4183 (2006).
[CrossRef]

Opt. Express (1)

Opt. Lett. (1)

Proc. Natl. Acad. Sci. USA (1)

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, Proc. Natl. Acad. Sci. USA 107, 8085 (2010).
[CrossRef]

Sensors (1)

H. Jeong, N. H. Cho, U. Jung, C. Lee, J. Y. Kim, and J. Kim, Sensors 12, 6920 (2012).
[CrossRef]

Other (1)

M. H. Niemz, Laser-Tissue Interactions: Fundamentals and Applications (Springer Verlag, 2007).

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Figures (3)

Fig. 1.
Fig. 1.

(a) Schematic diagram of PMM-OCT and (b) waveforms of current and magnetic flux density in pulsed mode (dotted box).

Fig. 2.
Fig. 2.

(a) Temporal variations of temperature at two different locations (0.1 mm and 30 mm away from iron core, number of measurement n=5) in sinusoidal and pulsed modes. (b) Magnetization of solenoids with and without iron core in pulsed and sinusoidal modes, measured with respect to distance from end surface of solenoid (n=10): an inset of (b) shows an enlarged view of magnetization at distances between 20 and 40 mm, indicated as a red dotted box.

Fig. 3.
Fig. 3.

M-mode image of phantoms 30 mm away from iron core under external pulsed magnetic flux of 9 kG: (a) control, 0μg/ml and (b) 100μg/ml of magnetic nanoparticles (FeNPs). Note that top and bottom surfaces of the phantoms are indicated. Z=depth.

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