Abstract

A simple technique for remote scanning of the focal plane in temporal focusing multiphoton microscopy is demonstrated both theoretically and experimentally. A new on-axis light propagation optical setup design enables this scanning, which was considered not feasible in previous studies. The focal plane is axially displaced by the movement of a remote optical device, consisting of a double prism grating, and optionally a cylindrical lens. The displacement is linear, and its slope is inversely proportional to the square of the optical system’s magnification.

© 2012 Optical Society of America

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E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
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[CrossRef]

H. Dana, A. Marom, N. Kruger, A. Ellman, and S. Shoham, Proc. SPIE 8226, 822603 (2012).
[CrossRef]

2011 (8)

O. Therrien, B. Aubé, S. Pagés, P. D. Koninck, and D. Côté, Biomed. Opt. Express 2, 696 (2011).
[CrossRef]

A. Straub, M. E. Durst, and C. Xu, Biomed. Opt. Express 2, 80 (2011).
[CrossRef]

L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, Opt. Lett. 36, 139 (2011).
[CrossRef]

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
[CrossRef]

H. Dana and S. Shoham, Opt. Express 19, 4937 (2011).
[CrossRef]

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
[CrossRef]

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[CrossRef]

E. E. Hoover, M. D. Young, E. V. Chandler, A. Luo, J. J. Field, K. E. Sheetz, A. W. Sylvester, and J. A. Squier, Biomed. Opt. Express 2, 113 (2011).
[CrossRef]

2010 (5)

B. F. Grewe, D. Langer, H. Kasper, B. M. Kampa, and F. Helmchen, Nat. Methods 7, 399 (2010).
[CrossRef]

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

D. Kim and P. T. C. So, Opt. Lett. 35, 1602 (2010).
[CrossRef]

D. N. Vitek, D. E. Adams, A. Johnson, P. S. Tsai, S. Backus, C. G. Durfee, D. Kleinfeld, and J. A. Squier, Opt. Express 18, 18086 (2010).
[CrossRef]

B. Andrasfalvy, B. Zemelman, J. Tang, and A. Vaziri, Proc. Natl. Acad. Sci. U.S.A. 107, 11981 (2010).
[CrossRef]

2009 (1)

R. Du, K. Bi, S. Zeng, D. Li, S. Xue, and Q. Luo, J. Mod. Opt. 56, 81 (2009).
[CrossRef]

2008 (2)

A. Vaziri, J. Tang, H. Shroff, and C. Shank, Proc. Natl. Acad. Sci. U.S.A. 105, 20221 (2008).
[CrossRef]

E. Papagiakoumou, V. de Sars, D. Oron, and V. Emiliani, Opt. Express 16, 22039 (2008).
[CrossRef]

2007 (2)

2006 (1)

2005 (4)

2003 (1)

1990 (1)

W. Denk, J. H. Strickler, and W. W. Webb, Science 248, 73 (1990).
[CrossRef]

Adams, D. E.

Andrasfalvy, B.

B. Andrasfalvy, B. Zemelman, J. Tang, and A. Vaziri, Proc. Natl. Acad. Sci. U.S.A. 107, 11981 (2010).
[CrossRef]

Anselmi, F.

F. Anselmi, C. Ventalon, A. Bégue, D. Ogden, and V. Emiliani, Proc. Natl. Acad. Sci. U.S.A. 108, 19504 (2011).
[CrossRef]

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

Aubé, B.

Backus, S.

Begue, A.

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

Bégue, A.

F. Anselmi, C. Ventalon, A. Bégue, D. Ogden, and V. Emiliani, Proc. Natl. Acad. Sci. U.S.A. 108, 19504 (2011).
[CrossRef]

Bi, K.

R. Du, K. Bi, S. Zeng, D. Li, S. Xue, and Q. Luo, J. Mod. Opt. 56, 81 (2009).
[CrossRef]

Blake, G. A.

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
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E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
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E. J. Botcherby, R. Juskaitis, M. J. Booth, and T. Wilson, Opt. Lett. 32, 2007 (2007).
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Botcherby, E. J.

E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
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E. J. Botcherby, R. Juskaitis, M. J. Booth, and T. Wilson, Opt. Lett. 32, 2007 (2007).
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Bouma, B.

Burns, L. D.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
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Chandler, E. V.

Chang, C. Y.

Chang, N. S.

Chen, S. J.

Chen, Y.

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
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Cheng, L. C.

Chiovini, B.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
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Cho, K. C.

Cocker, E. D.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
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Côté, D.

Dana, H.

H. Dana, A. Marom, N. Kruger, A. Ellman, and S. Shoham, Proc. SPIE 8226, 822603 (2012).
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H. Dana and S. Shoham, Opt. Express 19, 4937 (2011).
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de Sars, V.

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

E. Papagiakoumou, V. de Sars, D. Oron, and V. Emiliani, Opt. Express 16, 22039 (2008).
[CrossRef]

Débarre, D.

E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
[CrossRef]

Denk, W.

F. Helmchen and W. Denk, Nat. Methods 2, 932 (2005).
[CrossRef]

W. Denk, J. H. Strickler, and W. W. Webb, Science 248, 73 (1990).
[CrossRef]

Dong, C. Y.

Du, R.

R. Du, K. Bi, S. Zeng, D. Li, S. Xue, and Q. Luo, J. Mod. Opt. 56, 81 (2009).
[CrossRef]

Durfee, C. G.

Durst, M.

Durst, M. E.

El Gamal, A.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
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Ellman, A.

H. Dana, A. Marom, N. Kruger, A. Ellman, and S. Shoham, Proc. SPIE 8226, 822603 (2012).
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Emiliani, V.

F. Anselmi, C. Ventalon, A. Bégue, D. Ogden, and V. Emiliani, Proc. Natl. Acad. Sci. U.S.A. 108, 19504 (2011).
[CrossRef]

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

E. Papagiakoumou, V. de Sars, D. Oron, and V. Emiliani, Opt. Express 16, 22039 (2008).
[CrossRef]

Field, J. J.

Ghosh, K. K.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
[CrossRef]

Gluckstad, J.

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

Gobel, W.

W. Gobel, B. M. Kampa, and F. Helmchen, Nat. Methods 4, 73 (2007).
[CrossRef]

Grewe, B. F.

B. F. Grewe, D. Langer, H. Kasper, B. M. Kampa, and F. Helmchen, Nat. Methods 7, 399 (2010).
[CrossRef]

Guo, C. L.

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
[CrossRef]

Helmchen, F.

B. F. Grewe, D. Langer, H. Kasper, B. M. Kampa, and F. Helmchen, Nat. Methods 7, 399 (2010).
[CrossRef]

W. Gobel, B. M. Kampa, and F. Helmchen, Nat. Methods 4, 73 (2007).
[CrossRef]

F. Helmchen and W. Denk, Nat. Methods 2, 932 (2005).
[CrossRef]

Hillier, D.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Holland, D. B.

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
[CrossRef]

Hoover, E. E.

Isacoff, E. Y.

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

Johnson, A.

Juskaitis, R.

Juškaitis, R.

E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
[CrossRef]

Kampa, B. M.

B. F. Grewe, D. Langer, H. Kasper, B. M. Kampa, and F. Helmchen, Nat. Methods 7, 399 (2010).
[CrossRef]

W. Gobel, B. M. Kampa, and F. Helmchen, Nat. Methods 4, 73 (2007).
[CrossRef]

Kasper, H.

B. F. Grewe, D. Langer, H. Kasper, B. M. Kampa, and F. Helmchen, Nat. Methods 7, 399 (2010).
[CrossRef]

Kaszás, A.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Katona, G.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Kim, D.

Kleinfeld, D.

Kohl, M. M.

E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
[CrossRef]

Koninck, P. D.

Kruger, N.

H. Dana, A. Marom, N. Kruger, A. Ellman, and S. Shoham, Proc. SPIE 8226, 822603 (2012).
[CrossRef]

Kuo, C. H.

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
[CrossRef]

Langer, D.

B. F. Grewe, D. Langer, H. Kasper, B. M. Kampa, and F. Helmchen, Nat. Methods 7, 399 (2010).
[CrossRef]

Li, D.

R. Du, K. Bi, S. Zeng, D. Li, S. Xue, and Q. Luo, J. Mod. Opt. 56, 81 (2009).
[CrossRef]

Lin, C. Y.

Luo, A.

Luo, Q.

R. Du, K. Bi, S. Zeng, D. Li, S. Xue, and Q. Luo, J. Mod. Opt. 56, 81 (2009).
[CrossRef]

Maák, P.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Marom, A.

H. Dana, A. Marom, N. Kruger, A. Ellman, and S. Shoham, Proc. SPIE 8226, 822603 (2012).
[CrossRef]

Maslov, K.

Nimmerjahn, A.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
[CrossRef]

Ogden, D.

F. Anselmi, C. Ventalon, A. Bégue, D. Ogden, and V. Emiliani, Proc. Natl. Acad. Sci. U.S.A. 108, 19504 (2011).
[CrossRef]

Oron, D.

Ouyang, M.

J. Y. Yu, C. H. Kuo, D. B. Holland, Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. L. Guo, J. Biomed. Opt. 16, 116009 (2011).
[CrossRef]

Pagés, S.

Papagiakoumou, E.

E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nat. Methods 7, 848 (2010).
[CrossRef]

E. Papagiakoumou, V. de Sars, D. Oron, and V. Emiliani, Opt. Express 16, 22039 (2008).
[CrossRef]

Paulsen, O.

E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
[CrossRef]

Pitris, C.

Rao, B.

Roska, B.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Rózsa, B.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Schnitzer, M. J.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv, A. El Gamal, and M. J. Schnitzer, Nat. Methods 8, 871 (2011).
[CrossRef]

Shank, C.

A. Vaziri, J. Tang, H. Shroff, and C. Shank, Proc. Natl. Acad. Sci. U.S.A. 105, 20221 (2008).
[CrossRef]

Sheetz, K. E.

Shiskov, M.

Shoham, S.

H. Dana, A. Marom, N. Kruger, A. Ellman, and S. Shoham, Proc. SPIE 8226, 822603 (2012).
[CrossRef]

H. Dana and S. Shoham, Opt. Express 19, 4937 (2011).
[CrossRef]

Shroff, H.

A. Vaziri, J. Tang, H. Shroff, and C. Shank, Proc. Natl. Acad. Sci. U.S.A. 105, 20221 (2008).
[CrossRef]

Silberberg, Y.

Smith, C. W.

E. J. Botcherby, C. W. Smith, M. M. Kohl, D. Débarre, M. J. Booth, R. Juškaitis, O. Paulsen, and T. Wilson, Proc. Natl. Acad. Sci. U.S.A. 109, 2919 (2012).
[CrossRef]

So, P. T. C.

Squier, J. A.

Straub, A.

Strickler, J. H.

W. Denk, J. H. Strickler, and W. W. Webb, Science 248, 73 (1990).
[CrossRef]

Sylvester, A. W.

Szalay, G.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Tal, E.

Tang, J.

B. Andrasfalvy, B. Zemelman, J. Tang, and A. Vaziri, Proc. Natl. Acad. Sci. U.S.A. 107, 11981 (2010).
[CrossRef]

A. Vaziri, J. Tang, H. Shroff, and C. Shank, Proc. Natl. Acad. Sci. U.S.A. 105, 20221 (2008).
[CrossRef]

Tearney, G.

Therrien, O.

Tsai, P. S.

van Howe, J.

Vaziri, A.

B. Andrasfalvy, B. Zemelman, J. Tang, and A. Vaziri, Proc. Natl. Acad. Sci. U.S.A. 107, 11981 (2010).
[CrossRef]

A. Vaziri, J. Tang, H. Shroff, and C. Shank, Proc. Natl. Acad. Sci. U.S.A. 105, 20221 (2008).
[CrossRef]

Ventalon, C.

F. Anselmi, C. Ventalon, A. Bégue, D. Ogden, and V. Emiliani, Proc. Natl. Acad. Sci. U.S.A. 108, 19504 (2011).
[CrossRef]

Veress, M.

G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska, and B. Rózsa, Nat. Methods 9, 201 (2012).
[CrossRef]

Vitek, D. N.

Vizi, E. S.

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Proc. Natl. Acad. Sci. U.S.A. (4)

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Science (1)

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Figures (2)

Fig. 1.
Fig. 1.

TF line-illumination optical setups. (a) Standard TF optical setup involves off-axis light propagation: the grating diffracts off-axis light toward the optical axis. (b) On-axis TF optical setup: a combination of two prisms and a grating (DPG) keeps the central laser wavelength propagating along a single axis. This design simplifies the optical setup and enables remote scanning of the focal plane, by axially moving the DPG and cylindrical lens unit. By removing the cylindrical lens this setup illuminates a wide-field without change in the xz light propagation scheme. Fcyl=75mm, ftube=200mm. (c) Illustration of the remote scanning concept. For each DPG location a different optically sectioned plane is illuminated.

Fig. 2.
Fig. 2.

Characterization of TF remote axial scanning. (a) Axial shift of the focal plane versus the movement of the DPG and the cylindrical lens for three different magnifications. Dots represent experimental measurements and solid lines are according to Eq. (1). (b) and (c) Lateral and axial sectioning of the illuminated line for different focal plane shifts. Insets in (c) show individual measurements of axial sectioning, fit by a Cauchy–Lorentz function.

Equations (1)

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d=DM2·n1/n2,

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