Abstract

We present a holographic imaging device with a low-coherence light source that uses the reflection of the objective lens as reference illumination. This results in a simple setup and allows applications to microscopy with only small modifications of the setup for aberration measurements. In addition, it opens the prospects to in vivo ophthalmic imaging. We present in vitro experiments using a resolution test target to quantify the system performance. We demonstrate that we can achieve diffraction-limited resolution and show the possibility of aberration correction. We also present preliminary results using a scattering sample.

© 2012 Optical Society of America

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2012 (1)

2011 (2)

2010 (1)

M. K. Kim, SPIE Rev. 1, 018005 (2010).
[CrossRef]

2007 (2)

2006 (1)

2005 (1)

2002 (2)

G. Pedrini and H. J. Tiziani, Appl. Opt. 41, 4489 (2002).
[CrossRef]

M. J. Booth, M. A. A. Neil, R. Juškaitis, and T. Wilson, Proc. Natl. Acad. Sci. USA 995788 (2002).
[CrossRef]

2001 (2)

2000 (1)

1996 (1)

J. C. Wyant and J. Schmit, Proc. SPIE 2782, 26 (1996).
[CrossRef]

1994 (1)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Anna, T.

Aspert, N.

Bachmann, A. H.

Beaurepaire, E.

Booth, M. J.

M. J. Booth, M. A. A. Neil, R. Juškaitis, and T. Wilson, Proc. Natl. Acad. Sci. USA 995788 (2002).
[CrossRef]

Bourquin, S.

Charrière, F.

Colomb, T.

Cuche, E.

De Nicola, S.

Débarre, D.

Depeursinge, C.

Depeursinge, C. D.

Drexler, W.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Facomprez, A.

Fercher, A. F.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Ferraro, P.

Finizio, A.

Hitzenberger, C. K.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Jeong, K.

Juškaitis, R.

M. J. Booth, M. A. A. Neil, R. Juškaitis, and T. Wilson, Proc. Natl. Acad. Sci. USA 995788 (2002).
[CrossRef]

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Kato, J.

Kim, M. K.

Kühn, J.

Lasser, T.

Leitgeb, R. A.

Liu, C.

Marian, A.

Marquet, P.

Massatsch, P.

Massig, J. H.

Mehta, D. S.

Michaely, R.

Mizuno, J.

Montfort, F.

Neil, M. A. A.

M. J. Booth, M. A. A. Neil, R. Juškaitis, and T. Wilson, Proc. Natl. Acad. Sci. USA 995788 (2002).
[CrossRef]

Nolte, D. D.

K. Jeong, J. J. Turek, and D. D. Nolte, Appl. Opt. 46, 4999 (2007).
[CrossRef]

D. D. Nolte, in Optical Interferometry for Biology and Medicine (Springer, 2012), p. 307.

Ohta, S.

Pedrini, G.

Pierattini, G.

Sattmann, H.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Schmetterer, L. F.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Schmit, J.

J. C. Wyant and J. Schmit, Proc. SPIE 2782, 26 (1996).
[CrossRef]

Shakher, C.

Srivastava, V.

Stadelmaier, A.

Strasser, I.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Tiziani, H. J.

Turek, J. J.

Unfried, C. J.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

Wilson, T.

M. J. Booth, M. A. A. Neil, R. Juškaitis, and T. Wilson, Proc. Natl. Acad. Sci. USA 995788 (2002).
[CrossRef]

Wyant, J. C.

J. C. Wyant and J. Schmit, Proc. SPIE 2782, 26 (1996).
[CrossRef]

Yamaguchi, I.

Proc. Natl. Acad. Sci. USA (1)

M. J. Booth, M. A. A. Neil, R. Juškaitis, and T. Wilson, Proc. Natl. Acad. Sci. USA 995788 (2002).
[CrossRef]

Appl. Opt. (5)

J. Opt. Soc. Am. A (1)

Opt. Express (2)

Opt. Lett. (3)

Proc. SPIE (2)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, L. F. Schmetterer, I. Strasser, and C. J. Unfried, Proc. SPIE 2083, 356 (1994).
[CrossRef]

J. C. Wyant and J. Schmit, Proc. SPIE 2782, 26 (1996).
[CrossRef]

SPIE Rev. (1)

M. K. Kim, SPIE Rev. 1, 018005 (2010).
[CrossRef]

Other (1)

D. D. Nolte, in Optical Interferometry for Biology and Medicine (Springer, 2012), p. 307.

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Figures (4)

Fig. 1.
Fig. 1.

Proposed in-line common-path holography setup (see text for details). EOM, electro-optic phase modulator.

Fig. 2.
Fig. 2.

(a) Magnitude of complex RTT object wave after combination of three phase-shifted holograms; (b) RTT after digital focusing; (c) zoom of orange area in (b); (d) intensity profile along white dashed line in (c).

Fig. 3.
Fig. 3.

Demonstration of aberration compensation. (a) Part of RTT before fitting of Zernike polynomials and after manual tilt correction; (b) corresponding phase image; (c) part of RTT after fitting of Zernike; (d) corresponding phase profile; (e) three-dimensional rendering of central part of RTT.

Fig. 4.
Fig. 4.

Imaging of scattering samples. Letter “n” printed on firm matte paper. (a) Magnitude of complex object wave in hologram plane; (b) magnitude after reconstruction.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

Iψ(x,y)=|UR(x,y)|2+|U(x,y)|2+2UR(x,y)U(x,y)cos(φ(x,y)+ψ),
U(x,y)=1+i4UR[(I0Iπ/2)+i(IπIπ/2)].
U^I(ξ,η;z)=exp[iπλz(ξ2+η2)]U^(ξ,η),
U^I(ξ,η;z)=exp[iπλz(ξ2+η2)]F{ΓHU(ξ,η)},

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