Abstract

We report on an implementation of coherence revival-based heterodyne swept source optical coherence tomography that is capable of simultaneously imaging the anterior and posterior eye. A polarization-encoded sample arm was used to efficiently focus orthogonal polarizations on the anterior segment and retina. Depth encoding was achieved using coherence revival, which allows for multiple depths within a sample to be simultaneously imaged and frequency encoded by carefully controlling the optical pathlength of each sample path. This design is a significant step toward whole-eye optical coherence tomography (OCT), which would enable customized ray-traced modeling of patient eyes to improve refractive surgical interventions and eliminate optical artifacts in retinal OCT diagnostics. We demonstrated the feasibility of this system for in vivo imaging by simultaneously acquiring images of the anterior segments and retinas in healthy human volunteers.

© 2012 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
    [CrossRef]
  2. J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
    [CrossRef]
  3. M. Zhao, A. N. Kuo, and J. A. Izatt, Opt. Express 18, 8923 (2010).
    [CrossRef]
  4. A.-H. Dhalla, D. Nankivil, and J. A. Izatt, Biomed. Opt. Express 3, 633 (2012).
    [CrossRef]
  5. A. V. Goncharov and C. Dainty, J. Opt. Soc. Am. A 24, 2157 (2007).
    [CrossRef]
  6. T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, Opt. Express 19, 3044 (2011).
    [CrossRef]
  7. M. Choma, M. Sarunic, C. Yang, and J. Izatt, Opt. Express 11, 2183 (2003).
    [CrossRef]

2012

2011

2010

2007

2003

1994

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

1991

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Biedermann, B. R.

Choma, M.

Dainty, C.

Dhalla, A.-H.

Eigenwillig, C. M.

Fujimoto, J. G.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Goncharov, A. V.

Hee, M. R.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

Huang, D.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Huber, R.

Izatt, J.

Izatt, J. A.

A.-H. Dhalla, D. Nankivil, and J. A. Izatt, Biomed. Opt. Express 3, 633 (2012).
[CrossRef]

M. Zhao, A. N. Kuo, and J. A. Izatt, Opt. Express 18, 8923 (2010).
[CrossRef]

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

Klein, T.

Kuo, A. N.

Lin, C. P.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Nankivil, D.

Puliafito, C. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Sarunic, M.

Schuman, J. S.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

Swanson, E. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

Wang, J.

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Wieser, W.

Yang, C.

Zhao, M.

Arch. Ophthalmol.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, Arch. Ophthalmol. 112, 1584 (1994).
[CrossRef]

Biomed. Opt. Express

J. Opt. Soc. Am. A

Lasers Surg. Med.

D. Huang, J. Wang, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, Lasers Surg. Med. 11, 419 (1991).
[CrossRef]

Opt. Express

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1.
Fig. 1.

SSOCT system schematic. BR; balanced receiver; PM, power meter; UP, unused ports; PC, polarization controller. Sample arm: red and blue lines depict the retinal and anterior segment imaging paths, respectively. Overlapping paths are shown in purple. L, lens; HWP, half-wave plate; PBS, polarizing beam splitter; FM, fold mirror; G, galvanometers.

Fig. 2.
Fig. 2.

Sensitivity falloff profiles for the retinal (top) and anterior segment (bottom) imaging channels. Red horizontal lines are drawn at 6dB sensitivity from the peak.

Fig. 3.
Fig. 3.

Simultaneously acquired anterior segment and retinal images. A, single frame as acquired before cropping, consisting of 2000(lateral)×2304(axial) samples, acquired in 20 ms. ZPD, zero pathlength difference position; +1CL, cavity length offset position. B and C, separated anterior segment and retinal images, averaged over 5 frames. Scale bars are 1 mm, 1mm×1mm, and 250μm×1° in A, B, and C, respectively. The dynamic ranges of the image data in B and C were 56 and 40 dB, respectively.

Metrics