Abstract

We report on a noninvasive and noncontact all-optical method to measure the elasticity of the cornea. We use a pulsed laser to excite surface acoustic waves (SAW) that propagate on the corneal surface, then use a phase-sensitive optical coherence tomography system to remotely record the SAWs from which the corneal elasticity is estimated. In addition, the system is able to provide real-time tomographic images of the cornea being examined, an important consideration for clinical studies. While precisely maintaining a range of intraocular pressures (IOP), a series of measurements is performed on ex vivo intact primate eyes. The measurement results not only demonstrate the feasibility of the proposed system to remotely measure the corneal elasticity, but also suggest a strong correlation between the corneal stiffness and the true IOP.

© 2012 Optical Society of America

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2012 (1)

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

2011 (5)

2010 (1)

R. K. Wang, and A. L. Nuttall, J. Biomed. Opt. 15, 056005 (2010).
[CrossRef]

2009 (1)

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

2007 (1)

A. Kotecha, Surv. Ophthalmol. 52, S109 (2007).
[CrossRef]

2005 (2)

W. J. Dupps, J. Refract. Surg. 21, 186 (2005).
[CrossRef]

J. Liu and C. J. Roberts, J. Cataract Refract. Surg. 31, 146 (2005).
[CrossRef]

2003 (1)

G. Wollensak, E. Spoerl, and T. Seiler, J. Cataract Refract. Surg. 29, 1780 (2003).
[CrossRef]

2002 (1)

I. F. Comaish and M. A. Lawless, J. Cataract Refract. Surg. 28, 2206 (2002).
[CrossRef]

1999 (1)

G. Orssengo and D. Pye, Bull. Math. Biol. 61, 551 (1999).
[CrossRef]

1994 (1)

M. R. Bryant, K. Szerenyi, H. Schmotzer, and P. J. McDonnell, Invest. Ophthalmol. Vis. Sci. 35, 3022 (1994).

1992 (1)

A. Neubrand and P. Hess, J. Appl. Phys. 71, 227 (1992).
[CrossRef]

Alonso-Caneiro, D.

An, L.

Bercoff, J.

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

Bryant, M. R.

M. R. Bryant, K. Szerenyi, H. Schmotzer, and P. J. McDonnell, Invest. Ophthalmol. Vis. Sci. 35, 3022 (1994).

Cartwright, N. E. K.

N. E. K. Cartwright, J. R. Tyrer, and J. Marshall, Invest. Ophthalmol. Vis. Sci. 52, 4324 (2011).
[CrossRef]

Comaish, I. F.

I. F. Comaish and M. A. Lawless, J. Cataract Refract. Surg. 28, 2206 (2002).
[CrossRef]

Dupps, W. J.

W. J. Dupps, J. Refract. Surg. 21, 186 (2005).
[CrossRef]

Fink, M.

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

Gennisson, J.

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

Guan, G.

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

Hess, P.

A. Neubrand and P. Hess, J. Appl. Phys. 71, 227 (1992).
[CrossRef]

Huang, Z.

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

Huang, Z. H.

Johnstone, M.

Kaluzny, B. J.

Karnowski, K.

Kotecha, A.

A. Kotecha, Surv. Ophthalmol. 52, S109 (2007).
[CrossRef]

Kowalczyk, A.

Lawless, M. A.

I. F. Comaish and M. A. Lawless, J. Cataract Refract. Surg. 28, 2206 (2002).
[CrossRef]

Li, C.

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

Li, C. H.

Li, P.

Liu, J.

J. Liu and C. J. Roberts, J. Cataract Refract. Surg. 31, 146 (2005).
[CrossRef]

Marshall, J.

N. E. K. Cartwright, J. R. Tyrer, and J. Marshall, Invest. Ophthalmol. Vis. Sci. 52, 4324 (2011).
[CrossRef]

McDonnell, P. J.

M. R. Bryant, K. Szerenyi, H. Schmotzer, and P. J. McDonnell, Invest. Ophthalmol. Vis. Sci. 35, 3022 (1994).

Neubrand, A.

A. Neubrand and P. Hess, J. Appl. Phys. 71, 227 (1992).
[CrossRef]

Nuttall, A. L.

R. K. Wang, and A. L. Nuttall, J. Biomed. Opt. 15, 056005 (2010).
[CrossRef]

Orssengo, G.

G. Orssengo and D. Pye, Bull. Math. Biol. 61, 551 (1999).
[CrossRef]

Pye, D.

G. Orssengo and D. Pye, Bull. Math. Biol. 61, 551 (1999).
[CrossRef]

Reif, R.

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

Roberts, C. J.

J. Liu and C. J. Roberts, J. Cataract Refract. Surg. 31, 146 (2005).
[CrossRef]

Schmotzer, H.

M. R. Bryant, K. Szerenyi, H. Schmotzer, and P. J. McDonnell, Invest. Ophthalmol. Vis. Sci. 35, 3022 (1994).

Seiler, T.

G. Wollensak, E. Spoerl, and T. Seiler, J. Cataract Refract. Surg. 29, 1780 (2003).
[CrossRef]

Shen, T. T.

Spoerl, E.

G. Wollensak, E. Spoerl, and T. Seiler, J. Cataract Refract. Surg. 29, 1780 (2003).
[CrossRef]

Szerenyi, K.

M. R. Bryant, K. Szerenyi, H. Schmotzer, and P. J. McDonnell, Invest. Ophthalmol. Vis. Sci. 35, 3022 (1994).

Tanter, M.

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

Touboul, D.

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

Tyrer, J. R.

N. E. K. Cartwright, J. R. Tyrer, and J. Marshall, Invest. Ophthalmol. Vis. Sci. 52, 4324 (2011).
[CrossRef]

Wang, R. K.

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

L. An, P. Li, T. T. Shen, and R. K. Wang, Biomed. Opt. Express 2, 2770 (2011).
[CrossRef]

P. Li, L. An, T. T. Shen, M. Johnstone, and R. K. Wang, Biomed. Opt. Express 2, 3109 (2011).
[CrossRef]

R. K. Wang, and A. L. Nuttall, J. Biomed. Opt. 15, 056005 (2010).
[CrossRef]

Wang, R. K. K.

Wojtkowski, M.

Wollensak, G.

G. Wollensak, E. Spoerl, and T. Seiler, J. Cataract Refract. Surg. 29, 1780 (2003).
[CrossRef]

Biomed. Opt. Express (2)

Bull. Math. Biol. (1)

G. Orssengo and D. Pye, Bull. Math. Biol. 61, 551 (1999).
[CrossRef]

IEEE Trans. Med. Imaging (1)

M. Tanter, D. Touboul, J. Gennisson, J. Bercoff, and M. Fink, IEEE Trans. Med. Imaging 28, 1881 (2009).
[CrossRef]

Invest. Ophthalmol. Vis. Sci. (2)

M. R. Bryant, K. Szerenyi, H. Schmotzer, and P. J. McDonnell, Invest. Ophthalmol. Vis. Sci. 35, 3022 (1994).

N. E. K. Cartwright, J. R. Tyrer, and J. Marshall, Invest. Ophthalmol. Vis. Sci. 52, 4324 (2011).
[CrossRef]

J. Appl. Phys. (1)

A. Neubrand and P. Hess, J. Appl. Phys. 71, 227 (1992).
[CrossRef]

J. Biomed. Opt. (1)

R. K. Wang, and A. L. Nuttall, J. Biomed. Opt. 15, 056005 (2010).
[CrossRef]

J. Cataract Refract. Surg. (3)

G. Wollensak, E. Spoerl, and T. Seiler, J. Cataract Refract. Surg. 29, 1780 (2003).
[CrossRef]

I. F. Comaish and M. A. Lawless, J. Cataract Refract. Surg. 28, 2206 (2002).
[CrossRef]

J. Liu and C. J. Roberts, J. Cataract Refract. Surg. 31, 146 (2005).
[CrossRef]

J. R. Soc. Interface (1)

C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, J. R. Soc. Interface 9, 831 (2012).
[CrossRef]

J. Refract. Surg. (1)

W. J. Dupps, J. Refract. Surg. 21, 186 (2005).
[CrossRef]

Opt. Express (2)

Surv. Ophthalmol. (1)

A. Kotecha, Surv. Ophthalmol. 52, S109 (2007).
[CrossRef]

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